University of Haifa

About: University of Haifa is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 7558 authors who have published 27141 publications receiving 711629 citations. The organization is also known as: Haifa University & Universiṭat Ḥefah.

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Abstract: Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) e4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE e2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.

Internet pornography: A social psychological perspective on internet sexuality

Abstract: Spectacular growth in availability of sexually explicit material on the Internet challenges sexual science to study antecedents and consequences of experience with such content. The current analysi...

Hardness and algorithms for rainbow connection

Abstract: An edge-colored graph G is rainbow connected if any two vertices are connected by a path whose edges have distinct colors. The rainbow connection of a connected graph G, denoted rc(G), is the smallest number of colors that are needed in order to make G rainbow connected. In the first result of this paper we prove that computing rc(G) is NP-Hard solving an open problem from Caro et al. (Electron. J. Comb. 15, 2008, Paper R57). In fact, we prove that it is already NP-Complete to decide if rc(G)=2, and also that it is NP-Complete to decide whether a given edge-colored (with an unbounded number of colors) graph is rainbow connected. On the positive side, we prove that for every ?>0, a connected graph with minimum degree at least ? n has bounded rainbow connection, where the bound depends only on ?, and a corresponding coloring can be constructed in polynomial time. Additional non-trivial upper bounds, as well as open problems and conjectures are also presented.

Place-Names in Israel's Ideological Struggle over the Administered Territories

Abstract: This paper deals with the symbolic role of place-names as expressions of ideological values. Names are symbolic elements of landscape that reflect abstract or concrete national and local sentiments...

Age-dependent effects of chronic stress on brain plasticity and depressive behavior.

Abstract: Exposure to chronic mild stress (CMS) is known to induce anhedonia in adult animals, and is associated with induction of depression in humans. However, the behavioral effects of CMS in young animals have not yet been characterized, and little is known about the long-term neurochemical effects of CMS in either young or adult animals. Here, we found that CMS induces anhedonia in adult but not in young animals, as measured by a set of behavioral paradigms. Furthermore, while CMS decreased neurogenesis and levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult animals, it increased these parameters in young animals. We also found that CMS altered alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor GluR1 subunit levels in the hippocampus and the nucleus accumbens of adult, but not young animals. Finally, no significant differences were observed between the effects of CMS on circadian corticosterone levels in the different age groups. The substantially different neurochemical effects chronic stress exerts in young and adult animals may explain the behavioral resilience to such stress young animals possess.