Institution
University of Haifa
Education•Haifa, Israel•
About: University of Haifa is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 7558 authors who have published 27141 publications receiving 711629 citations. The organization is also known as: Haifa University & Universiṭat Ḥefah.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The results suggest that the hippocampus is crucial for social cognition, and imply that beyond framing physical locations, the hippocampus computes a more general, inclusive, abstract, and multidimensional cognitive map consistent with its role in episodic memory.
336 citations
••
TL;DR: Findings could represent a case of negative imprinting whereby collective peer group education which includes an incessant exposure to peers from the first days of life and an unimpeded tactile relationship among the peers between ages 0–6 results in sexual avoidance and exogamy.
Abstract: Premarital sexual behavior and marriage patterns were investigated in Israeli kibbutzim. All adolescents and adults of the second generation (N =65)in one kibbutz were studied. There were no cases of heterosexual activity between any two native adolescents of the same peer group and no cases of marriage between any two members of the same peer group. The avoidance was completely voluntary. Among 2769 marriages contracted by second generation adults in all kibbutzim, there were no cases of intra—peer group marriage. These findings could represent a case of negative imprinting whereby collective peer group education which includes an incessant exposure to peers from the first days of life and an unimpeded tactile relationship among the peers between ages 0–6 results in sexual avoidance and exogamy.
335 citations
••
TL;DR: The results suggest that IL‐1 contributes to the regulation of memory processes as well as short‐ and long‐term plasticity within the hippocampus, which has important implications to several conditions in humans, which are associated with long-term defects inIL‐1 signaling.
Abstract: The cytokine interleukin-1 (IL-1) is produced by peripheral immune cells as well as glia and neurons within the brain; it plays a major role in immune to brain communication and in modulation of neural, neuroendocrine, and behavioral systems during illness. Although previous studies demonstrated that excess levels of IL-1 impaired memory processes and neural plasticity, it has been suggested that physiological levels of IL-1 are involved in hippocampal-dependent memory and long-term potentiation (LTP). To examine this hypothesis, we studied IL-1 receptor type I knockout (IL-1rKO) mice in several paradigms of memory function and hippocampal plasticity. In the spatial version of the water maze test, IL-1rKO mice displayed significantly longer latency to reach a hidden platform, compared with wild-type controls. Furthermore, IL-1rKO exhibited diminished contextual fear conditioning. In contrast, IL-1rKO mice were similar to control animals in hippocampal-independent memory tasks; i.e., their performance in the visually guided task of the water maze and the auditory-cued fear conditioning was normal. Electrophysiologically, anesthetized IL-1rKO mice exhibited enhanced paired-pulse inhibition in response to perforant path stimulation and no LTP in the dentate gyrus. In vitro, decreased paired-pulse responses, as well as a complete absence of LTP, were observed in the CA1 region of hippocampal slices taken from IL-1rKO mice compared with WT controls. These results suggest that IL-1 contributes to the regulation of memory processes as well as short- and long-term plasticity within the hippocampus. These findings have important implications to several conditions in humans, which are associated with long-term defects in IL-1 signaling, such as mutations in the IL-1 receptor accessory protein-like gene, which are involved in a frequent form of X-linked mental retardation.
335 citations
••
TL;DR: This paper examined the relationship between perceived threat posed by an outgroup population and the perceived threat mediates the relations between size of the outgroup and exclusionary attitudes toward the out-group.
333 citations
••
University of Toronto1, University of Haifa2, Pomeranian Medical University3, Creighton University4, University of Oslo5, Université de Montréal6, McGill University7, Erasmus University Rotterdam8, Sheba Medical Center9, Tel Aviv University10, University of British Columbia11, University of Western Ontario12, Princess Margaret Cancer Centre13, University of Pennsylvania14, Medical University of Vienna15, Harvard University16, Mayo Clinic17, Fox Chase Cancer Center18, Cincinnati Children's Hospital Medical Center19, Ohio State University20, Curie Institute21, Hamilton Health Sciences22, Clalit Health Services23, University of San Francisco24, Rambam Health Care Campus25, University of Chicago26, City of Hope National Medical Center27, Cedars-Sinai Medical Center28, University of Vermont29, University of Alberta30, University of Manitoba31, New York University32, York University33, University of Saskatchewan34, University of Texas MD Anderson Cancer Center35, University of Michigan36
TL;DR: Nearly one‐half of the women at risk for breast cancer had taken no preventive option, relying solely on screening, and there were large differences in the uptake of the different preventive options by country of residence.
Abstract: Several options for cancer prevention are available for women with a BRCA1 or BRCA2 mutation, including prophylactic surgery, chemoprevention and screening. The authors report on preventive practices in women with mutations from 9 countries and examine differences in uptake according to country. Women with a BRCA1 or BRCA2 mutation were contacted after receiving their genetic test result and were questioned regarding their preventive practices. Information was recorded on prophylactic mastectomy, prophylactic oophorectomy, use of tamoxifen and screening (MRI and mammography). Two thousand six hundred seventy-seven women with a BRCA1 or BRCA2 mutation from 9 countries were included. The follow-up questionnaire was completed a mean of 3.9 years (range 1.5-10.3 years) after genetic testing. One thousand five hundred thirty-one women (57.2%) had a bilateral prophylactic oophorectomy. Of the 1,383 women without breast cancer, 248 (18.0%) had had a prophylactic bilateral mastectomy. Among those who did not have a prophylactic mastectomy, only 76 women (5.5%) took tamoxifen and 40 women (2.9%) took raloxifene for breast cancer prevention. Approximately one-half of the women at risk for breast cancer had taken no preventive option, relying solely on screening. There were large differences in the uptake of the different preventive options by country of residence. Prophylactic oophorectomy is now generally accepted by women and their physicians as a cancer preventive measure. However, only the minority of women with a BRCA1 or BRCA2 mutation opt for prophylactic mastectomy or take tamoxifen for the prevention of hereditary breast cancer. Approximately one-half of women at risk for breast cancer rely on screening alone.
333 citations
Authors
Showing all 7747 results
Name | H-index | Papers | Citations |
---|---|---|---|
Markku Laakso | 162 | 945 | 142292 |
M.-Marsel Mesulam | 150 | 558 | 90772 |
Michael Levin | 111 | 986 | 45667 |
Peter Schmidt | 105 | 638 | 61822 |
Eviatar Nevo | 95 | 848 | 40066 |
Uri Alon | 91 | 442 | 54822 |
Dan Roth | 85 | 523 | 28166 |
Simon G. Potts | 82 | 249 | 31557 |
Russell G. Foster | 79 | 318 | 23206 |
Leo Radom | 79 | 604 | 34075 |
Stevan E. Hobfoll | 74 | 271 | 35870 |
Larry Davidson | 69 | 459 | 20177 |
Alan R. Templeton | 67 | 249 | 28320 |
Uri Gneezy | 65 | 211 | 29671 |
Benny Pinkas | 64 | 156 | 21122 |