University of Haifa

About: University of Haifa is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Poison control. The organization has 7558 authors who have published 27141 publications receiving 711629 citations. The organization is also known as: Haifa University & Universiṭat Ḥefah.

Medial Prefrontal Cortex Multiple Roles in Fear and Extinction

Abstract: Anxiety disorders are among the most common mental health problems; deficits in extinction have been implicated as a possible risk factor for the development of these disorders. Fear extinction refers to the ability to adapt as situations change by learning to suppress a previously acquired fear. Attention is directed toward the medial prefrontal cortex (mPFC) and the interaction it has with the amygdala as this circuit has crucial roles in both the acquisition and the extinction of fear associations. Here, we review converging evidence from different laboratories pointing to multiple roles that the mPFC has in fear regulation. Research on rodents indicates opposing roles that the different subregions of the mPFC have in exciting and inhibiting fear. In addition, this review aims to survey the findings addressing the mechanisms by which the mPFC regulates fear. Data from our laboratory and others show that changes in plasticity in the mPFC could be one of the mechanisms mediating extinction of fear. Recent findings on rodents and nonhuman primates report that modifying plasticity in the mPFC alters fear and affects extinction, suggesting that targeting plasticity in the mPFC could constitute a therapeutic tool for the treatment of anxiety disorders.

Alliance, contiguity, wealth, and political stability: Is the lack of conflict among democracies a statistical artifact? 1

Abstract: Scholars increasingly are accepting the empirical generalization that democracies almost never go to war with each other, and infrequently even engage in militarized disputes with each other. It has not been clear, however, whether the rarity of conflict between democracies is caused by some aspect of being democratic, or whether it is caused by some other variable or variables that may be correlated with democracy. Using data on all independent states for the period 1946–1986, we examine the effects of political system type, distance, wealth, economic growth, alliances, and political stability. The results suggest that, although most of the other variables do have an effect, as hypothesized, there still seems to be an independent effect of political system type: democracies engage in militarized disputes with each other less than would be expected by chance. The effect may be enhanced by political stability; that is, states which can be perceived as stable democracies are less likely to be involved in di...

Applying practice theory to the study of consumption: Theoretical and methodological considerations

Abstract: In the context of continuing debate in social theory and philosophy about the structure-agency problematic, recent years have seen scholars (re)turn to this theoretical complexity through so-called theories of social practices. Practice theories are a set of cultural and philosophical accounts that focus on the conditions surrounding the practical carrying out of social life. It has roots in the philosophy of Heidegger and Wittgenstein and social scientific roots in the work of early Bourdieu, early Giddens, late Foucault and Butler. Their insights have recently become fused in a composite philosophical ontology of practices developed by Theodore Schatzki (1996, 2002) and colleagues (Schatzki et al., 2001). Together with the useful theoretical mapping provided by Reckwitz (2002) – who sketches practice theory as an ideal type, drawing out its peculiarities through a contrast with theoretical narratives in the broader domain of ‘cultural theories’ – it could be argued that practice theories have come to occupy salient theoretical space across the social sciences and humanities. When Reckwitz (2002) drafted his overview, the principles of these perspectives had already made inroads in ‘science studies, gender studies and organizational studies’ (p. 257). In recent years, this has spread to include anthropology, cultural studies, design studies, environment and

The interplay between gait, falls and cognition: can cognitive therapy reduce fall risk?

Abstract: In this article, we briefly summarize the incidence and significant consequences of falls among older adults, the insufficient effectiveness of commonly used multifactorial interventions and the evidence linking falls and cognitive function. Recent pharmacologic and nonpharmacologic studies that evaluated the effects of cognitive therapy on fall risk are reviewed. The results of this article illustrate the potential utility of multiple, diverse forms of cognitive therapy for reducing fall risk. The article also indicates that large-scale, randomized controlled trials are warranted and that additional research is needed to better understand the pathophysiologic mechanisms underlying the interplay between human mobility, fall risk and cognitive function. Nonetheless, we suggest that multimodality interventions that combine motor and cognitive therapy should, eventually, be incorporated into clinical practice to enable older adults and patients to move safer and with a reduced fall risk.

Emodin--a secondary metabolite with multiple ecological functions in higher plants.

Abstract: Summary The anthraquinone emodin, identified in 17 plant families distributed worldwide, has numerous biological activities, some of which exhibit a wide spectrum of ecological impacts by mediating biotic or abiotic interactions of plants with their environment. Here the evidence for direct and indirect effects of emodin on plant survival and reproduction is reviewed. Emodin in vegetative organs may help protect plants against herbivores, pathogens, competitors and extrinsic abiotic factors (e.g. high light intensities). In unripe fruit pulp, emodin may facilitate seed dispersal by protecting the immature fruit against predispersal seed predation whereas in ripe pulp it may deter frugivores and thus reduce the chances that seeds will be defecated beneath the parent plant. It also accelerates the passage of seeds through the digestive tract, potentially reducing dispersal distance and increasing seed viability upon dispersal. In certain circumstances both of the last two effects could also have negative fitness consequences for plants. Natural selection should favor secondary metabolites with multiple functions because they protect the plants against a variety of unpredictable biotic and abiotic environments. Such metabolites also enhance plant defenses by using different molecular targets of specific enemies through a variety of mechanisms of action. Emodin illustrates the wide and often overlooked potential for chemical multifunctionality in plant secondary metabolites.