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Institution

University of Hamburg

EducationHamburg, Germany
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.


Papers
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Journal ArticleDOI
TL;DR: It is believed that the study of tree-ring anatomy is emerging as a promising approach in tree biology and climate change research, particularly if complemented by physiological and ecological studies.
Abstract: Variability in xylem anatomy is of interest to plant scientists because of the role water transport plays in plant performance and survival. Insights into plant adjustments to changing environmental conditions have mainly been obtained through structural and functional comparative studies between taxa or within taxa on contrasting sites or along environmental gradients. Yet, a gap exists regarding the study of hydraulic adjustments in response to environmental changes over the lifetimes of plants. In trees, dated tree-ring series are often exploited to reconstruct dynamics in ecological conditions, and recent work in which wood-anatomical variables have been used in dendrochronology has produced promising results. Environmental signals identified in water-conducting cells carry novel information reflecting changes in regional conditions and are mostly related to short, sub-annual intervals. Although the idea of investigating environmental signals through wood anatomical time series goes back to the 1960s, it is only recently that low-cost computerized image-analysis systems have enabled increased scientific output in this field. We believe that the study of tree-ring anatomy is emerging as a promising approach in tree biology and climate change research, particularly if complemented by physiological and ecological studies. This contribution presents the rationale, the potential, and the methodological challenges of this innovative approach.

473 citations

Journal ArticleDOI
TL;DR: In this paper, the authors evaluate the unit costs of desalinated water for five main processes and regressions are used to analyze the main influencing factors to the costs of these processes.
Abstract: [1] Many regions of the world are facing formidable freshwater scarcity. Although there is substantial scope for economizing on the consumption of water without affecting its service level, the main response to water scarcity has been to increase the supply. To a large extent, this is done by transporting water from places where it is abundant to places where it is scarce. At a smaller scale and without a lot of public and political attention, people have started to tap into the sheer limitless resource of desalinated water. This study looks at the development of desalination and its costs over time. The unit costs of desalinated water for five main processes are evaluated, followed by regressions to analyze the main influencing factors to the costs. The unit costs for all processes have fallen considerably over the years. This study suggests that a cost of $1/m3 for seawater desalination and $0.6/m3 for brackish water would be feasible today. The costs will continue to decline in the future as technology progresses. In addition, a literature review on the costs of water transport is conducted in order to estimate the total cost of desalination and the transport of desalinated water to selected water stress cities. Transport costs range from a few cents per cubic meter to over a dollar. A 100 m vertical lift is about as costly as a 100 km horizontal transport ($0.05–0.06/m3). Transport makes desalinated water prohibitively expensive in highlands and continental interiors but not elsewhere.

473 citations

Journal ArticleDOI
TL;DR: The phylogeographic approach is illustrated with two case studies: the initial dispersal out of Africa, and the colonization of Europe, which show how modern humans spread across the authors' planet.

472 citations

Journal ArticleDOI
TL;DR: In this article, a broad corporate governance index was constructed and five additional variables related to ownership structure, board characteristics, and leverage were applied to provide a comprehensive description of firm-level corporate governance for a representative sample of Swiss firms.
Abstract: Recent empirical research shows evidence of a positive relationship between the quality of firm-specific corporate governance and firm valuation. Instead of looking at one single corporate governance mechanism in isolation, we construct a broad corporate governance index and apply five additional variables related to ownership structure, board characteristics, and leverage to provide a comprehensive description of firm-level corporate governance for a representative sample of Swiss firms. To control for potential endogeneity of these six governance mechanisms, we develop a system of simultaneous equations and apply three-stage least squares (3SLS). Our results support the widespread hypothesis of a positive relationship between corporate governance and firm valuation.

472 citations

Journal ArticleDOI
Padhraig Gormley, Verneri Anttila1, Verneri Anttila2, Bendik S. Winsvold3, Bendik S. Winsvold4, Priit Palta5, Tõnu Esko2, Tõnu Esko6, Tõnu Esko7, Tune H. Pers, Kai-How Farh2, Kai-How Farh1, Kai-How Farh8, Ester Cuenca-León, Mikko Muona, Nicholas A. Furlotte, Tobias Kurth9, Tobias Kurth10, Andres Ingason11, George McMahon12, Lannie Ligthart13, Gisela M. Terwindt14, Mikko Kallela15, Tobias Freilinger16, Tobias Freilinger17, Caroline Ran18, Scott G. Gordon19, Anine H. Stam14, Stacy Steinberg11, Guntram Borck20, Markku Koiranen21, Lydia Quaye22, Hieab H.H. Adams23, Terho Lehtimäki24, Antti-Pekka Sarin5, Juho Wedenoja5, David A. Hinds, Julie E. Buring1, Julie E. Buring9, Markus Schürks25, Paul M. Ridker1, Paul M. Ridker9, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson11, Susan M. Ring12, Jouke-Jan Hottenga13, Brenda W.J.H. Penninx13, Markus Färkkilä15, Ville Artto15, Mari A. Kaunisto5, Salli Vepsäläinen15, Rainer Malik17, Andrew C. Heath26, Pamela A. F. Madden26, Nicholas G. Martin19, Grant W. Montgomery19, Mitja I. Kurki, Mart Kals7, Reedik Mägi7, Kalle Pärn7, Eija Hamalainen5, Hailiang Huang1, Hailiang Huang2, Andrea Byrnes2, Andrea Byrnes1, Lude Franke27, Jie Huang28, Evie Stergiakouli12, Phil Lee1, Phil Lee2, Cynthia Sandor29, Caleb Webber29, Zameel M. Cader30, Zameel M. Cader29, Bertram Müller-Myhsok31, Stefan Schreiber32, Thomas Meitinger33, Johan G. Eriksson34, Johan G. Eriksson5, Veikko Salomaa34, Kauko Heikkilä5, Elizabeth Loehrer1, Elizabeth Loehrer23, André G. Uitterlinden23, Albert Hofman23, Cornelia M. van Duijn23, Lynn Cherkas22, Linda M. Pedersen4, Audun Stubhaug4, Audun Stubhaug3, Christopher Sivert Nielsen4, Christopher Sivert Nielsen35, Minna Männikkö21, Evelin Mihailov7, Lili Milani7, Hartmut Göbel, Ann-Louise Esserlind36, Anne Francke Christensen36, Thomas Hansen36, Thomas Werge37, Thomas Werge38, Thomas Werge36, Jaakko Kaprio5, Jaakko Kaprio34, Arpo Aromaa34, Olli T. Raitakari39, Olli T. Raitakari40, M. Arfan Ikram23, Tim D. Spector22, Marjo-Riitta Järvelin, Andres Metspalu7, Christian Kubisch41, David P. Strachan42, Michel D. Ferrari14, Andrea Carmine Belin18, Martin Dichgans17, Maija Wessman5, Arn M. J. M. van den Maagdenberg14, John-Anker Zwart3, John-Anker Zwart4, Dorret I. Boomsma13, George Davey Smith12, Kari Stefansson43, Kari Stefansson11, Nicholas Eriksson, Mark J. Daly1, Mark J. Daly2, Benjamin M. Neale2, Benjamin M. Neale1, Jes Olesen36, Daniel I. Chasman1, Daniel I. Chasman9, Dale R. Nyholt44, Aarno Palotie 
TL;DR: For example, the authors identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to date is the first to be identified on chromosome X.
Abstract: Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.

471 citations


Authors

Showing all 46072 results

NameH-indexPapersCitations
Rudolf Jaenisch206606178436
Bruce M. Psaty1811205138244
Stefan Schreiber1781233138528
Chris Sander178713233287
Dennis J. Selkoe177607145825
Daniel R. Weinberger177879128450
Ramachandran S. Vasan1721100138108
Bradley Cox1692150156200
Anders Björklund16576984268
J. S. Lange1602083145919
Hannes Jung1592069125069
Andrew D. Hamilton1511334105439
Jongmin Lee1502257134772
Teresa Lenz1501718114725
Stefanie Dimmeler14757481658
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023282
2022817
20215,784
20205,491
20194,994
20184,587