Institution
University of Hamburg
Education•Hamburg, Germany•
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.
Papers published on a yearly basis
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TL;DR: The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at 2.76 TeV by the CMS experiment at the LHC as mentioned in this paper.
Abstract: The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV by the CMS experiment at the LHC. In the transverse momentum range pt = 5-10 GeV/c, the charged particle yield in the most central PbPb collisions is suppressed by up to a factor of 5 compared to the pp yield scaled by the number of incoherent nucleon-nucleon collisions. At higher pt, this suppression is significantly reduced, approaching roughly a factor of 2 for particles with pt in the range pt=40-100 GeV/c.
446 citations
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TL;DR: Addition of soluble L1Fc chimeric molecules does not restore Sema3A responsiveness of L1-deficient axons; instead, it converts the repulsion of wild-type axons into an attraction, further supporting a function for L1 in the Sema 3A transducing pathways within the growth cone.
446 citations
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TL;DR: In this paper, the authors present a Gleichlaufigkeitswert resultiert aus den klimatisch gepragten, gleichsinnig verlaufenden Zuwachsschwankungen (Weiserjahre) and den zufallig sich deckenden Kurvenabschnitten.
Abstract: Das in Mitteleuropa eingesetzte jahrringchronologische Datierungsverfahren wurde im Hinblick auf Rationalisierung und Aussagesicherheit gepruft. Als zeitliche Engpasse erwiesen sich die Probenentnahme, die Jahrringbreitenmessung, das Zeichnen der Zuwachskurven und vor allem der manuelle Kurvenvergleich. Durch Einsatz einer elektronischen Rechenanlage und anderer Hilfsmittel konnte der Ablauf beschleunigt werden. Fur eine sichere Synchronisierung von Jahrringfolgen wurde der dafur gewahlte Gleichlaufigkeitswert, untersucht. Obwohl sich der Streubereich dieses Wertes bei synchroner und unsynchroner Deckungslage weitgehend uberschneidet, gestattet der Gleichlaufigkeitswert dennoch eine objektive Differenzierung, an Hand derer visuell eine sichere Altersbestimmung moglich ist. Ein Gleichlaufigkeitswert resultiert aus den klimatisch gepragten, gleichsinnig verlaufenden Zuwachsschwankungen (Weiserjahre) und aus den zufallig sich deckenden Kurvenabschnitten. Die Werte beider Komponenten streuen. Erst wenn sich Werte au den beiden positiven Streufeldern summieren, liegt der daraus resultierende Gleichlaufigkeitswert auserhalb der Zufallsstreuung. Zur Demonstration des modifizierten dendrochronologischen Verfahrens wurden einige Datierungsbeispiele angefuhrt.
445 citations
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VU University Amsterdam1, University of Amsterdam2, University of New South Wales3, City University London4, University of York5, Karolinska Institutet6, University of Lübeck7, University of Hamburg8, University of Nottingham9, Australian National University10, King's College London11, University of Bern12, Tilburg University13
TL;DR: In this article, the effect of self-guided internet-based cognitive behavioral therapy (iCBT) in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response.
Abstract: IMPORTANCE Self-guided internet-based cognitive behavioral therapy (iCBT) has the potential to increase access and availability of evidence-based therapy and reduce the cost of depression treatment. OBJECTIVES To estimate the effect of self-guided iCBT in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response. DATA SOURCES A total of 13 384 abstracts were retrieved through a systematic literature search in PubMed, Embase, PsycINFO, and Cochrane Library from database inception to January 1, 2016. STUDY SELECTION Randomized clinical trials in which self-guided iCBT was compared with a control (usual care, waiting list, or attention control) in individuals with symptoms of depression. DATA EXTRACTION AND SYNTHESIS Primary authors provided individual participant data from 3876 participants from 13 of 16 eligible studies. Missing data were handled using multiple imputations. Mixed-effects models with participants nested within studies were used to examine treatment outcomes and moderators. MAIN OUTCOMES AND MEASURES Outcomes included the Beck Depression Inventory, Center for Epidemiological Studies-Depression Scale, and 9-item Patient Health Questionnaire scores. Scales were standardized across the pool of the included studies. RESULTS Of the 3876 study participants, the mean (SD) age was 42.0 (11.7) years, 2531 (66.0%) of 3832 were female, 1368 (53.1%) of 2574 completed secondary education, and 2262 (71.9%) of 3146 were employed. Self-guided iCBT was significantly more effective than controls on depressive symptoms severity (s =-0.21; Hedges g = 0.27) and treatment response (s = 0.53; odds ratio, 1.95; 95% CI, 1.52-2.50; number needed to treat, 8). Adherence to treatment was associated with lower depressive symptoms (s =-0.19; P =.001) and greater response to treatment (s = 0.90; P <.001). None of the examined participant and study-level variables moderated treatment outcomes. CONCLUSIONS AND RELEVANCE Self-guided iCBT is effective in treating depressive symptoms. The use of meta-analyses of individual participant data provides substantial evidence for clinical and policy decision making because self-guided iCBT can be considered as an evidence-based first-step approach in treating symptoms of depression. Several limitations of the iCBT should be addressed before it can be disseminated into routine care.
445 citations
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TL;DR: In this article, the authors survey the current debate on modelling and describe different perspectives on this debate, and relate these perspectives with earlier perspectives and show similarities and differences between these different approaches.
Abstract: In this article we survey the current debate on modelling and, describe different perspectives on this debate. We relate these perspectives with earlier perspectives and show similarities and differences between these different approaches.
444 citations
Authors
Showing all 46072 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rudolf Jaenisch | 206 | 606 | 178436 |
Bruce M. Psaty | 181 | 1205 | 138244 |
Stefan Schreiber | 178 | 1233 | 138528 |
Chris Sander | 178 | 713 | 233287 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Daniel R. Weinberger | 177 | 879 | 128450 |
Ramachandran S. Vasan | 172 | 1100 | 138108 |
Bradley Cox | 169 | 2150 | 156200 |
Anders Björklund | 165 | 769 | 84268 |
J. S. Lange | 160 | 2083 | 145919 |
Hannes Jung | 159 | 2069 | 125069 |
Andrew D. Hamilton | 151 | 1334 | 105439 |
Jongmin Lee | 150 | 2257 | 134772 |
Teresa Lenz | 150 | 1718 | 114725 |
Stefanie Dimmeler | 147 | 574 | 81658 |