Institution
University of Hamburg
Education•Hamburg, Germany•
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.
Topics: Population, Laser, Transplantation, Large Hadron Collider, Higgs boson
Papers published on a yearly basis
Papers
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TL;DR: It is shown that the RNA encoding the novel KCNQ5 channel is also expressed in brain and in sympathetic ganglia where it overlaps largely withKCNQ2 and KCNZ3, and a splice variant found in skeletal muscle displays altered gating kinetics, which indicates a molecular diversity of channels yielding M-type currents and suggests a role for KCnQ5 in the regulation of neuronal excitability.
395 citations
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TL;DR: This Review gives an overview of the methods developed during the last years to synthesize CIS nanocrystals and summarizes the possibilities to influence their shape, composition and crystallographic structure.
Abstract: Semiconductor nanocrystals possess size-dependent properties, which make them interesting candidates for a variety of applications, e.g., in solar energy conversion, lighting, display technology, or biolabelling. However, many of the best studied nanocrystalline materials contain toxic heavy metals; this seriously limits their potential for widespread application. One of the possible less toxic alternatives to cadmium- or lead-containing semiconductors is copper indium disulfide (CIS), a direct semiconductor with a bandgap in the bulk of 1.45 eV and a Bohr exciton radius of 4.1 nm. This Review gives an overview of the methods developed during the last years to synthesize CIS nanocrystals and summarizes the possibilities to influence their shape, composition and crystallographic structure. Also the potential of the application of CIS nanocrystals in biolabellling, photocatalysis, solar energy conversion, and light-emitting devices is discussed.
395 citations
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TL;DR: The expression pattern of KCNQ4 in the mouse auditory system raises the possibility of a central component in the DFNA2 hearing loss, the first ion channel shown to be specifically expressed in a sensory pathway.
Abstract: Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells. By using specific antibodies, we now show that KCNQ4 is situated at the basal membrane of these sensory cells. In the vestibular organs, KCNQ4 is restricted to the type I hair cells and the afferent calyx-like nerve endings ensheathing these sensory cells. Several lines of evidence suggest that KCNQ4 underlies the IK,n and gK,L currents that have been described in the outer and type I hair cells, respectively, and that are already open at resting potentials. KCNQ4 is also expressed in neurons of many, but not all, nuclei of the central auditory pathway, and is absent from most other brain regions. It is present, e.g., in the cochlear nuclei, the nuclei of the lateral lemniscus, and the inferior colliculus. This is the first ion channel shown to be specifically expressed in a sensory pathway. Moreover, the expression pattern of KCNQ4 in the mouse auditory system raises the possibility of a central component in the DFNA2 hearing loss.
395 citations
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TL;DR: Veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) support stabilizes patients with cardiogenic shock and may be impeded due to the increased afterload, resulting in a failing static left ventricle and in high mortality.
Abstract: Aims
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support stabilizes patients with cardiogenic shock. Despite improved oxygenation and peripheral circulation, LV unloading may be impeded due to the increased afterload, resulting in a failing static left ventricle and in high mortality.
Methods and results
We describe for the first time a large series of patients treated with the combination of VA-ECMO and Impella® compared with patients with VA-ECMO only. We retrospectively collected data on patients from two tertiary critical care referral centres. We enrolled 157 patients treated with VA-ECMO from January 2013 to April 2015: 123 received VA-ECMO support and 34 had concomitant treatment with VA-ECMO and Impella. A propensity-matching analysis was performed in a 2:1 ratio, resulting in 42 patients undergoing VA-ECMO alone (control group) compared with 21 patients treated with VA-ECMO and Impella. Patients in the VA-ECMO and Impella group had a significantly lower hospital mortality (47% vs. 80%, P < 0.001) and a higher rate of successful bridging to either recovery or further therapy (68% vs. 28%, P < 0.001) compared with VA-ECMO patients. A higher need for continuous veno-venous haemofiltration (48% vs. 19%, P = 0.02) and increased haemolysis (76% vs. 33%, P = 0.004) were reported in the study group due to higher survival. There was no difference in major bleeding rates between the two groups (VA-ECMO and Impella 38% vs. VA-ECMO 29%, P = 0.6).
Conclusions
Concomitant treatment with VA-ECMO and Impella may improve outcome in patients with cardiogenic shock compared with VA-ECMO only. Nevertheless, randomized studies are needed to validate these promising results further.
395 citations
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Monash University1, Alfred Hospital2, Carlos III Health Institute3, Instituto Politécnico Nacional4, University of Texas MD Anderson Cancer Center5, Charles University in Prague6, Seoul National University Hospital7, University of Hamburg8, Huazhong University of Science and Technology9, University of Pittsburgh10, University of Fukui11, AbbVie12, National and Kapodistrian University of Athens13
TL;DR: In this article, patients were randomized 2:1 to venetoclax plus low-dose cytarabine (LDAC) or placebo (n = 68) in 28-day cycles, plus LDAC on days 1 to 10.
395 citations
Authors
Showing all 46072 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rudolf Jaenisch | 206 | 606 | 178436 |
Bruce M. Psaty | 181 | 1205 | 138244 |
Stefan Schreiber | 178 | 1233 | 138528 |
Chris Sander | 178 | 713 | 233287 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Daniel R. Weinberger | 177 | 879 | 128450 |
Ramachandran S. Vasan | 172 | 1100 | 138108 |
Bradley Cox | 169 | 2150 | 156200 |
Anders Björklund | 165 | 769 | 84268 |
J. S. Lange | 160 | 2083 | 145919 |
Hannes Jung | 159 | 2069 | 125069 |
Andrew D. Hamilton | 151 | 1334 | 105439 |
Jongmin Lee | 150 | 2257 | 134772 |
Teresa Lenz | 150 | 1718 | 114725 |
Stefanie Dimmeler | 147 | 574 | 81658 |