Institution
University of Hamburg
Education•Hamburg, Germany•
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.
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Medical University of Vienna1, University of South Florida2, University of Bergen3, Laval University4, University of Washington5, University of Copenhagen6, Oswaldo Cruz Foundation7, University of Hong Kong8, Aarhus University9, Mahidol University10, University of British Columbia11, University of Hamburg12, Mackay Memorial Hospital13, Queen Mary University of London14, University of Melbourne15, University of Alabama16, Merck & Co.17
TL;DR: The 9vHPV vaccine prevented infection and disease related to HPV-31, 33, 45, 52, and 58 in a susceptible population and generated an antibody response to HPV -6, 11, 16, and 18 that was noninferior to that generated by the qHPV Vaccine.
Abstract: BackgroundThe investigational 9-valent viruslike particle vaccine against human papillomavirus (HPV) includes the HPV types in the quadrivalent HPV (qHPV) vaccine (6, 11, 16, and 18) and five additional oncogenic types (31, 33, 45, 52, and 58). Here we present the results of a study of the efficacy and immunogenicity of the 9vHPV vaccine in women 16 to 26 years of age. MethodsWe performed a randomized, international, double-blind, phase 2b–3 study of the 9vHPV vaccine in 14,215 women. Participants received the 9vHPV vaccine or the qHPV vaccine in a series of three intramuscular injections on day 1 and at months 2 and 6. Serum was collected for analysis of antibody responses. Swabs of labial, vulvar, perineal, perianal, endocervical, and ectocervical tissue were obtained and used for HPV DNA testing, and liquid-based cytologic testing (Papanicolaou testing) was performed regularly. Tissue obtained by means of biopsy or as part of definitive therapy (including a loop electrosurgical excision procedure and c...
1,109 citations
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TL;DR: In this article, the authors used the Advanced Microwave Scanning Radiometer-EOS (AMSR-E) to estimate sea ice concentration from the channels near 90 GHz, despite the enhanced atmospheric influence in these channels.
Abstract: [1] Recent progress in sea ice concentration remote sensing by satellite microwave radiometers has been stimulated by two developments: First, the new sensor Advanced Microwave Scanning Radiometer-EOS (AMSR-E) offers spatial resolutions of approximately 6 × 4 km at 89 GHz, nearly 3 times the resolution of the standard sensor SSM/I at 85 GHz (15 × 13 km). Second, a new algorithm enables estimation of sea ice concentration from the channels near 90 GHz, despite the enhanced atmospheric influence in these channels. This allows full exploitation of their horizontal resolution, which is up to 4 times finer than that of the channels near 19 and 37 GHz, the frequencies used by the most widespread algorithms for sea ice retrieval, the NASA-Team and Bootstrap algorithms. The ASI algorithm used combines a model for retrieving the sea ice concentration from SSM/I 85-GHz data proposed by Svendsen et al. (1987) with an ocean mask derived from the 18-, 23-, and 37-GHz AMSR-E data using weather filters. During two ship campaigns, the correlation of ASI, NASA-Team 2, and Bootstrap algorithms ice concentrations with bridge observations were 0.80, 0.79, and 0.81, respectively. Systematic differences over the complete AMSR-E period (2002–2006) between ASI and NASA-Team 2 are below −2 ± 8.8%, and between ASI and Bootstrap are 1.7 ± 10.8%. Among the geophysical implications of the ASI algorithm are: (1) Its higher spatial resolution allows better estimation of crucial variables in numerical atmospheric and ocean models, for example, the heat flux between ocean and atmosphere, especially near coastlines and in polynyas. (2) It provides an additional time series of ice area and extent for climate studies.
1,105 citations
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TL;DR: The evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment is reviewed.
Abstract: Most cancer deaths are caused by haematogenous metastatic spread and subsequent growth of tumour cells at distant organs. Disseminating tumour cells present in the peripheral blood and bone marrow can now be detected and characterized at the single-cell level. These cells are highly relevant to the study of the biology of early metastatic spread and provide a diagnostic source in patients with overt metastases. Here we review the evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment.
1,103 citations
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Toronto Western Hospital1, University of Toronto2, Boston University3, Columbia University4, Mayo Clinic5, University of Turin6, University of Florence7, Mount Sinai Hospital8, University of Miami9, Case Western Reserve University10, University of Hamburg11, Chiba University12, University of Hong Kong13, Max Delbrück Center for Molecular Medicine14
TL;DR: It is reported here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease, and it is shown that SOR l1 directs trafficking of APP into recycling pathways and that when SORl1 is underexpressed, APP is sorted into Aβ-generating compartments.
Abstract: The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.
1,093 citations
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TL;DR: Ausgehend von der jungsten Diagnose eines "Practice Turn" in der Sozial-theorie and empirischen Forschungspraxis arbeitet der Artikel Strukturmerk-male einer "Praxistheorie" or "Theorie sozialer Praktiken" im Vergleich zu alternativen SozIAL-and Kulturtheorien heraus as mentioned in this paper.
Abstract: Ausgehend von der jungsten Diagnose eines 'Practice Turn' in der Sozial-theorie und empirischen Forschungspraxis arbeitet der Artikel Strukturmerk-male einer 'Praxistheorie' oder 'Theorie sozialer Praktiken' im Vergleich zu alternativen Sozial- und Kulturtheorien heraus. Von besonderer Bedeutung erweisen sich dabei drei Grundannahmen: eine 'implizite', 'informelle' Logik der Praxis und Verankerung des Sozialen im praktischen Wissen und 'Konnen'; eine 'Materialitat' sozialer Praktiken in ihrer Abhangigkeit von Korpern und Artefakten; schlieslich ein Spannungsfeld von Routinisiertheit und systematisch be-grundbarer Unberechenbarkeit von Praktiken.
1,092 citations
Authors
Showing all 46072 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rudolf Jaenisch | 206 | 606 | 178436 |
Bruce M. Psaty | 181 | 1205 | 138244 |
Stefan Schreiber | 178 | 1233 | 138528 |
Chris Sander | 178 | 713 | 233287 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Daniel R. Weinberger | 177 | 879 | 128450 |
Ramachandran S. Vasan | 172 | 1100 | 138108 |
Bradley Cox | 169 | 2150 | 156200 |
Anders Björklund | 165 | 769 | 84268 |
J. S. Lange | 160 | 2083 | 145919 |
Hannes Jung | 159 | 2069 | 125069 |
Andrew D. Hamilton | 151 | 1334 | 105439 |
Jongmin Lee | 150 | 2257 | 134772 |
Teresa Lenz | 150 | 1718 | 114725 |
Stefanie Dimmeler | 147 | 574 | 81658 |