Institution
University of Hamburg
Education•Hamburg, Germany•
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.
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Max Planck Society1, Yerevan Physics Institute2, Centre national de la recherche scientifique3, University of Hamburg4, Humboldt University of Berlin5, Durham University6, École Polytechnique7, Dublin Institute for Advanced Studies8, University of Montpellier9, Joseph Fourier University10, DSM11, North-West University12, Ruhr University Bochum13, Charles University in Prague14, University of Namibia15
TL;DR: In this paper, an alternative approach is proposed based on the detection and identification of EBL absorption features in high-energy spectra of objects of known redshift, which provides the most stringent upper limit to date on the EBL in the Opt-NIR band, which appears significantly lower than expected from the current direct estimates and very close to the absolute lower limit represented by the integrated light of resolved galaxies.
Abstract: The diffuse Extragalactic Background Light (EBL) contains unique information about the epochs of formation and the history of evolution of galaxies. Unfortunately, direct measurements are subject to large systematic uncertainties due to the difficulties in the accurate model-based subtraction of the bright foregrounds. An alternative approach is based on the detection and identification of EBL absorption features in high-energy spectra of objects of known redshift. Here we exploit this method on the blazars H 2356-309 (z=0.165) and 1ES 1101-232 (z=0.186), newly discovered at TeV energies by the H.E.S.S. Collaboration. They are the most distant sources with measured spectra known so far at these energies. Their hard spectra provide the most stringent upper limit to date on the EBL in the Opt--NIR band, which appears significantly lower than expected from the current "direct" estimates and very close to the absolute lower limit represented by the integrated light of resolved galaxies. In addition to important cosmological implications, this result shows that the intergalactic space is more transparent to gamma-rays than previously thought, expanding the horizon of the TeV Universe.
651 citations
TL;DR: The mtDNA pool of present-day Brazilians clearly reflects the imprints of the early Portuguese colonization process (involving directional mating), as well as the recent immigrant waves (from Europe) of the last century.
Abstract: We have analyzed 247 Brazilian mtDNAs for hypervariable segment (HVS)–I and selected restriction fragment-length–polymorphism sites, to assess their ancestry in different continents. The total sample showed nearly equal amounts of Native American, African, and European matrilineal genetic contribution but with regional differences within Brazil. The mtDNA pool of present-day Brazilians clearly reflects the imprints of the early Portuguese colonization process (involving directional mating), as well as the recent immigrant waves (from Europe) of the last century. The subset of 99 mtDNAs from the southeastern region encompasses nearly all mtDNA haplogroups observed in the total Brazilian sample; for this regional subset, HVS-II was analyzed, providing, in particular, some novel details of the African mtDNA phylogeny.
650 citations
TL;DR: The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data.
Abstract: Most modern treatment protocols for acute lymphoblastic leukaemia (ALL) include the analysis of minimal residual disease (MRD). To ensure comparable MRD results between different MRD-polymerase chain reaction (PCR) laboratories, standardization and quality control are essential. The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. The application of these guidelines ensures identical interpretation of MRD data between different laboratories of the same MRD-based clinical protocol. Furthermore, the ESG-MRD-ALL guidelines will facilitate the comparison of MRD data obtained in different treatment protocols, including those with new drugs.
648 citations
German Cancer Research Center1, Heidelberg University2, St. Jude Children's Research Hospital3, University of Toronto4, Ontario Institute for Cancer Research5, Institute of Cancer Research6, University of California, San Francisco7, Cincinnati Children's Hospital Medical Center8, Sapienza University of Rome9, University of Warsaw10, Boston Children's Hospital11, University of Bonn12, University of Hamburg13, Medical University of Vienna14, French Institute of Health and Medical Research15, Karolinska Institutet16, University of Freiburg17, Cork University Hospital18, Hadassah Medical Center19, Otto-von-Guericke University Magdeburg20, Copenhagen University Hospital21, Vanderbilt University Medical Center22, Children's Hospital of Philadelphia23, Washington University in St. Louis24, University of Göttingen25, Augsburg College26, University of Münster27, Radboud University Nijmegen28, VU University Medical Center29, University Medical Center Freiburg30, Ludwig Maximilian University of Munich31, University of Tübingen32, University of Basel33, Masaryk University34, University of Cambridge35, University of Amsterdam36, Necker-Enfants Malades Hospital37, Institut Gustave Roussy38, Aix-Marseille University39, University of Düsseldorf40, Virginia Commonwealth University41, University of Würzburg42, New York University43, Henry Ford Hospital44, University of Texas MD Anderson Cancer Center45, University of Queensland46, McGill University47
TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.
648 citations
Authors
Showing all 46072 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Rudolf Jaenisch | 206 | 606 | 178436 |
| Bruce M. Psaty | 181 | 1205 | 138244 |
| Stefan Schreiber | 178 | 1233 | 138528 |
| Chris Sander | 178 | 713 | 233287 |
| Dennis J. Selkoe | 177 | 607 | 145825 |
| Daniel R. Weinberger | 177 | 879 | 128450 |
| Ramachandran S. Vasan | 172 | 1100 | 138108 |
| Bradley Cox | 169 | 2150 | 156200 |
| Anders Björklund | 165 | 769 | 84268 |
| J. S. Lange | 160 | 2083 | 145919 |
| Hannes Jung | 159 | 2069 | 125069 |
| Andrew D. Hamilton | 151 | 1334 | 105439 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Teresa Lenz | 150 | 1718 | 114725 |
| Stefanie Dimmeler | 147 | 574 | 81658 |