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Institution

University of Hamburg

EducationHamburg, Germany
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.


Papers
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Journal ArticleDOI
TL;DR: The identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (Kglu) is reported and it is demonstrated that the previously annotated deacetylase, sirtuin 5 (SIRT5), is aLysine deglutarylase.

610 citations

Journal ArticleDOI
Georges Aad1, T. Abajyan2, Brad Abbott3, Jalal Abdallah  +2942 moreInstitutions (201)
TL;DR: In this paper, the spin and parity quantum numbers of the Higgs boson were studied based on the collision data collected by the ATLAS experiment at the LHC, and the results showed that the standard model spin-parity J(...

608 citations

Journal ArticleDOI
TL;DR: Exome sequencing identified de novo germline or postzygotic mutations in three core components of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, highlighting the central role of PI3K-AKT signaling in vascular, limb and brain development.
Abstract: Megalencephaly-capillary malformation (MCAP) and megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndromes are sporadic overgrowth disorders associated with markedly enlarged brain size and other recognizable features. We performed exome sequencing in 3 families with MCAP or MPPH, and our initial observations were confirmed in exomes from 7 individuals with MCAP and 174 control individuals, as well as in 40 additional subjects with megalencephaly, using a combination of Sanger sequencing, restriction enzyme assays and targeted deep sequencing. We identified de novo germline or postzygotic mutations in three core components of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. These include 2 mutations in AKT3, 1 recurrent mutation in PIK3R2 in 11 unrelated families with MPPH and 15 mostly postzygotic mutations in PIK3CA in 23 individuals with MCAP and 1 with MPPH. Our data highlight the central role of PI3K-AKT signaling in vascular, limb and brain development and emphasize the power of massively parallel sequencing in a challenging context of phenotypic and genetic heterogeneity combined with postzygotic mosaicism.

608 citations

Journal ArticleDOI
TL;DR: It is shown that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia, but does not control erbB3 expression as in peripheral glia, and functions in peripheral and central glia at different stages and through different mechanisms.
Abstract: Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

608 citations

Book ChapterDOI
21 Sep 1992
TL;DR: The paper introduces the notion of conceptual neighborhood and its relevance for qualitative temporal reasoning and the resulting neighborhood-oriented representation and reasoning approach.
Abstract: A new approach to representing qualitative spatial knowledge and to spatial reasoning is presented This approach is motivated by cognitive considerations and is based on relative orientation information about spatial environments The approach aims at exploiting properties of physical space which surface when the spatial knowledge is structured according to conceptual neighborhood of spatial relations The paper introduces the notion of conceptual neighborhood and its relevance for qualitative temporal reasoning The extension of the benefits to spatial reasoning is suggested Several approaches to qualitative spatial reasoning are briefly reviewed Differences between the temporal and the spatial domain are outlined A way of transferring a qualitative temporal reasoning method to the spatial domain is proposed The resulting neighborhood-oriented representation and reasoning approach is presented and illustrated An example for an application of the approach is discussed

608 citations


Authors

Showing all 46072 results

NameH-indexPapersCitations
Rudolf Jaenisch206606178436
Bruce M. Psaty1811205138244
Stefan Schreiber1781233138528
Chris Sander178713233287
Dennis J. Selkoe177607145825
Daniel R. Weinberger177879128450
Ramachandran S. Vasan1721100138108
Bradley Cox1692150156200
Anders Björklund16576984268
J. S. Lange1602083145919
Hannes Jung1592069125069
Andrew D. Hamilton1511334105439
Jongmin Lee1502257134772
Teresa Lenz1501718114725
Stefanie Dimmeler14757481658
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023282
2022817
20215,784
20205,491
20194,994
20184,587