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Institution

University of Hamburg

EducationHamburg, Germany
About: University of Hamburg is a education organization based out in Hamburg, Germany. It is known for research contribution in the topics: Population & Laser. The organization has 45564 authors who have published 89286 publications receiving 2850161 citations. The organization is also known as: Hamburg University.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors discussed the lower Higgs boson mass bounds which come from the absolute stability of the Standard Model (SM) vacuum and from the Higgs inflation, as well as the prediction of the higgs mass coming from the asymptotic safety of the SM.
Abstract: We discuss the lower Higgs boson mass bounds which come from the absolute stability of the Standard Model (SM) vacuum and from the Higgs inflation, as well as the prediction of the Higgs boson mass coming from the asymptotic safety of the SM. We account for the three-loop renormalization group evolution of the couplings of the SM and for a part of the two-loop corrections that involve the QCD coupling α s to the initial conditions for their running. This is one step beyond the current state-of-the-art procedure (“one-loop matching-two-loop running”). This results in a reduction of the theoretical uncertainties in the Higgs boson mass bounds and predictions, associated with the SM physics, to 1–2 GeV. We find that with the account of existing experimental uncertainties in the mass of the top quark and α s (taken at the 2σ level) the bound reads M H ≥ M min (equality corresponds to the asymptotic-safety prediction), where $ {{M}_{{\min }}}=\left( {129\pm 6} \right) $ GeV. We argue that the discovery of the SM Higgs boson in this range would be in agreement with the hypothesis of the absence of new energy scales between the Fermi and Planck scales, whereas the coincidence of M H with M min would suggest that the electroweak scale is determined by Planck physics. In order to clarify the relation between the Fermi and Planck scales a construction of an electron-positron or muon collider with a center-of-mass energy ~ (200 + 200 GeV) (Higgs and t-quark factory) would be needed.

567 citations

Journal ArticleDOI
16 Nov 2017-Cell
TL;DR: An extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations, uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load.

567 citations

Journal ArticleDOI
TL;DR: In this paper, the authors discuss the nonequilibrium extension of the dynamical mean field theory (DMFT), which treats quantum fluctuations in the time domain and works directly in the thermodynamic limit.
Abstract: The study of nonequilibrium phenomena in correlated lattice systems has developed into one of the most active and exciting branches of condensed matter physics. This research field provides rich new insights that could not be obtained from the study of equilibrium situations, and the theoretical understanding of the physics often requires the development of new concepts and methods. On the experimental side, ultrafast pump-probe spectroscopies enable studies of excitation and relaxation phenomena in correlated electron systems, while ultracold atoms in optical lattices provide a new way to control and measure the time evolution of interacting lattice systems with a vastly different characteristic time scale compared to electron systems. A theoretical description of these phenomena is challenging because, first, the quantum-mechanical time evolution of many-body systems out of equilibrium must be computed and second, strong-correlation effects which can be of a nonperturbative nature must be addressed. This review discusses the nonequilibrium extension of the dynamical mean field theory (DMFT), which treats quantum fluctuations in the time domain and works directly in the thermodynamic limit. The method reduces the complexity of the calculation via a mapping to a self-consistent impurity problem, which becomes exact in infinite dimensions. Particular emphasis is placed on a detailed derivation of the formalism, and on a discussion of numerical techniques, which enable solutions of the effective nonequilibrium DMFT impurity problem. Insights gained into the properties of the infinite-dimensional Hubbard model under strong nonequilibrium conditions are summarized. These examples illustrate the current ability of the theoretical framework to reproduce and understand fundamental nonequilibrium phenomena, such as the dielectric breakdown of Mott insulators, photodoping, and collapse-and-revival oscillations in quenched systems. Furthermore, remarkable novel phenomena have been predicted by the nonequilibrium DMFT simulations of correlated lattice systems, including dynamical phase transitions and field-induced repulsion-to-attraction conversions.

565 citations

Journal ArticleDOI
TL;DR: In this article, a panel of 67 countries attempting to explain differences in self-reported levels of happiness by reference to, amongst other things, temperature and precipitation was analyzed using a panel-corrected least squares approach.

565 citations

Journal ArticleDOI
TL;DR: The results of several recent proof-of-principle studies are reviewed that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.
Abstract: Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave. In addition to these conventional antibodies, llamas, other camelids, and sharks also produce antibodies composed only of heavy chains. The antigen-binding site of these unusual heavy chain antibodies (hcAbs) is formed only by a single domain, designated VHH in camelid hcAbs and VNAR in shark hcAbs. VHH and VNAR are easily produced as recombinant proteins, designated single domain antibodies (sdAbs) or nanobodies. The CDR3 region of these sdAbs possesses the extraordinary capacity to form long fingerlike extensions that can extend into cavities on antigens, e.g., the active site crevice of enzymes. Other advantageous features of nanobodies include their small size, high solubility, thermal stability, refolding capacity, and good tissue penetration in vivo. Here we review the results of several recent proof-of-principle studies that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.

565 citations


Authors

Showing all 46072 results

NameH-indexPapersCitations
Rudolf Jaenisch206606178436
Bruce M. Psaty1811205138244
Stefan Schreiber1781233138528
Chris Sander178713233287
Dennis J. Selkoe177607145825
Daniel R. Weinberger177879128450
Ramachandran S. Vasan1721100138108
Bradley Cox1692150156200
Anders Björklund16576984268
J. S. Lange1602083145919
Hannes Jung1592069125069
Andrew D. Hamilton1511334105439
Jongmin Lee1502257134772
Teresa Lenz1501718114725
Stefanie Dimmeler14757481658
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023282
2022817
20215,784
20205,491
20194,994
20184,587