Showing papers by "University of Hawaii at Manoa published in 2003"

Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women: The Women's Health Initiative Randomized Trial

Abstract: ContextThe Women's Health Initiative trial of combined estrogen plus progestin was stopped early when overall health risks, including invasive breast cancer, exceeded benefits. Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography.ObjectiveTo determine the relationship among estrogen plus progestin use, breast cancer characteristics, and mammography recommendations.Design, Setting, and ParticipantsFollowing a comprehensive breast cancer risk assessment, 16 608 postmenopausal women aged 50 to 79 years with an intact uterus were randomly assigned to receive combined conjugated equine estrogens (0.625 mg/d) plus medroxyprogesterone acetate (2.5 mg/d) or placebo from 1993 to 1998 at 40 clinical centers. Screening mammography and clinical breast examinations were performed at baseline and yearly thereafter.Main Outcome MeasuresBreast cancer number and characteristics, and frequency of abnormal mammograms by estrogen plus progestin exposure.ResultsIn intent-to-treat analyses, estrogen plus progestin increased total (245 vs 185 cases; hazard ratio [HR], 1.24; weighted P<.001) and invasive (199 vs 150 cases; HR, 1.24; weighted P = .003) breast cancers compared with placebo. The invasive breast cancers diagnosed in the estrogen plus progestin group were similar in histology and grade but were larger (mean [SD], 1.7 cm [1.1] vs 1.5 cm [0.9], respectively; P = .04) and were at more advanced stage (regional/metastatic 25.4% vs 16.0%, respectively; P = .04) compared with those diagnosed in the placebo group. After 1 year, the percentage of women with abnormal mammograms was substantially greater in the estrogen plus progestin group (716 [9.4%] of 7656) compared with placebo group (398 [5.4%] of 7310; P<.001), a pattern which continued for the study duration.ConclusionsRelatively short-term combined estrogen plus progestin use increases incident breast cancers, which are diagnosed at a more advanced stage compared with placebo use, and also substantially increases the percentage of women with abnormal mammograms. These results suggest estrogen plus progestin may stimulate breast cancer growth and hinder breast cancer diagnosis.

The Art, Science, and Technology of Charcoal Production†

Abstract: In this review, we summarize the knowledge of the production and properties of charcoal that has been accumulated over the past 38 millenia. The manipulation of pressure, moisture content, and gas flow enables biomass carbonization with fixed-carbon yields that approachor attainthe theoretical limit after reaction times of a few tens of minutes. Much of the heat needed to carbonize the feed is released by vigorous, exothermic secondary reactions that reduce the formation of unwanted tars by augmenting the charcoal yield in a well-designed carbonizer. As a renewable fuel, charcoal has many attractive features: it contains virtually no sulfur or mercury and is low in nitrogen and ash; it is highly reactive yet easy to store and handle. Carbonized charcoal can be a good adsorbent with a large surface area and a semimetal with an electrical resistivity comparable to that of graphite. Recent advances in knowledge about the production and properties of charcoal presage its expanded use as a renewable fuel, red...

Nitrogenase gene diversity and microbial community structure: a cross-system comparison.

Abstract: Biological nitrogen fixation is an important source of fixed nitrogen for the biosphere. Microorganisms catalyse biological nitrogen fixation with the enzyme nitrogenase, which has been highly conserved through evolution. Cloning and sequencing of one of the nitrogenase structural genes, nifH, has provided a large, rapidly expanding database of sequences from diverse terrestrial and aquatic environments. Comparison of nifH phylogenies to ribosomal RNA phylogenies from cultivated microorganisms shows little conclusive evidence of lateral gene transfer. Sequence diversity far outstrips representation by cultivated representatives. The phylogeny of nitrogenase includes branches that represent phylotypic groupings based on ribosomal RNA phylogeny, but also includes paralogous clades including the alternative, non-molybdenum, non-vanadium containing nitrogenases. Only a few alternative or archaeal nitrogenase sequences have as yet been obtained from the environment. Extensive analysis of the distribution of nifH phylotypes among habitats indicates that there are characteristic patterns of nitrogen fixing microorganisms in termite guts, sediment and soil environments, estuaries and salt marshes, and oligotrophic oceans. The distribution of nitrogen-fixing microorganisms, although not entirely dictated by the nitrogen availability in the environment, is non-random and can be predicted on the basis of habitat characteristics. The ability to assay for gene expression and investigate genome arrangements provides the promise of new tools for interrogating natural populations of diazotrophs. The broad analysis of nitrogenase genes provides a basis for developing molecular assays and bioinformatics approaches for the study of nitrogen fixation in the environment.

Atmosphere-Warm Ocean Interaction and Its Impacts on Asian-Australian Monsoon Variation*

Abstract: Asian–Australian monsoon (A–AM) anomalies depend strongly on phases of El Nino (La Nina). Based on this distinctive feature, a method of extended singular value decomposition analysis was developed to analyze the changing characteristics of A–AM anomalies during El Nino (La Nina) from its development to decay. Two off-equatorial surface anticyclones dominate the A–AM anomalies during an El Nino—one over the south Indian Ocean (SIO) and the other over the western North Pacific (WNP). The SIO anticyclone, which affects climate conditions over the Indian Ocean, eastern Africa, and India, originates during the summer of a growing El Nino, rapidly reaches its peak intensity in fall, and decays when El Nino matures. The WNP anticyclone, on the other hand, forms in fall, attains maximum intensity after El Nino matures, and persists through the subsequent spring and summer, providing a prolonged impact on the WNP and east Asian climate. The monsoon anomalies associated with a La Nina resemble those durin...

TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions.

Abstract: Trace metal ions such as Zn2+, Fe2+, Cu2+, Mn2+, and Co2+ are required cofactors for many essential cellular enzymes, yet little is known about the mechanisms through which they enter into cells. We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca2+- and Mg2+-permeable cation channel, whose activity is regulated by intracellular Mg2+ and Mg2+·ATP and have designated native TRPM7-mediated currents as magnesium-nucleotide–regulated metal ion currents (MagNuM). Here we report that heterologously overexpressed TRPM7 in HEK-293 cells conducts a range of essential and toxic divalent metal ions with strong preference for Zn2+ and Ni2+, which both permeate TRPM7 up to four times better than Ca2+. Similarly, native MagNuM currents are also able to support Zn2+ entry. Furthermore, TRPM7 allows other essential metals such as Mn2+ and Co2+ to permeate, and permits significant entry of nonphysiologic or toxic metals such as Cd2+, Ba2+, and Sr2+. Equimolar replacement studies substituting 10 mM Ca2+ with the respective divalent ions reveal a unique permeation profile for TRPM7 with a permeability sequence of Zn2+ ≈ Ni2+ >> Ba2+ > Co2+ > Mg2+ ≥ Mn2+ ≥ Sr2+ ≥ Cd2+ ≥ Ca2+, while trivalent ions such as La3+ and Gd3+ are not measurably permeable. With the exception of Mg2+, which exerts strong negative feedback from the intracellular side of the pore, this sequence is faithfully maintained when isotonic solutions of these divalent cations are used. Fura-2 quenching experiments with Mn2+, Co2+, or Ni2+ suggest that these can be transported by TRPM7 in the presence of physiological levels of Ca2+ and Mg2+, suggesting that TRPM7 represents a novel ion-channel mechanism for cellular metal ion entry into vertebrate cells.

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

Abstract: The majority of cloned animals derived by nuclear transfer from somatic cell nuclei develop to the blastocyst stage but die after implantation. Mouse embryos that lack an Oct4 gene, which plays an essential role in control of developmental pluripotency, develop to the blastocyst stage and also die after implantation, because they lack pluripotent embryonic cells. Based on this similarity, we posited that cloned embryos derived from differentiated cell nuclei fail to establish a population of truly pluripotent embryonic cells because of faulty reactivation of key embryonic genes such as Oct4. To explore this hypothesis, we used an in silico approach to identify a set of Oct4-related genes whose developmental expression pattern is similar to that of Oct4. When expression of Oct4 and 10 Oct4-related genes was analyzed in individual cumulus cell-derived cloned blastocysts, only 62% correctly expressed all tested genes. In contrast to this incomplete reactivation of Oct4-related genes in somatic clones, ES cell-derived cloned blastocysts and normal control embryos expressed these genes normally. Notably, the contrast between expression patterns of the Oct4-related genes correlated with efficiency of embryonic development of somatic and ES cell-derived cloned blastocysts to term. These observations suggest that failure to reactivate the full spectrum of these Oct4-related genes may contribute to embryonic lethality in somatic-cell clones.

Atmospheric and environmental effects of the 1783-1784 Laki eruption: A review and reassessment

Abstract: [1] The 1783–1784 Laki flood lava eruption in Iceland emitted ∼122 megatons (Mt) SO2 into the atmosphere and maintained a sulfuric aerosol veil that hung over the Northern Hemisphere for >5 months. The eruption columns extended to 9–13 km and released ∼95 Mt SO2 into the upper troposphere/lower stratosphere (i.e., the polar jet stream), enforcing a net eastward dispersion of the plumes which reacted with atmospheric moisture to produce ∼200 Mt of H2SO4 aerosols. Away from source, the Laki aerosols were delivered to the surface by subsiding air masses within anticyclones. We show that ∼175 Mt of H2SO4 aerosols were removed as acid precipitation and caused the extreme volcanic pollution (i.e., dry fog) that effected Europe and other regions in 1783. The remaining ∼25 Mt stayed aloft at tropopause level for >1 year. The summer of 1783 was characterized by extreme and unusual weather, including an unusually hot July in western Europe, most likely caused by perseverance of southerly air currents. The following winter was one of the most severe winters on record in Europe and North America. In these regions, the annual mean surface cooling that followed the Laki eruption was about −1.3°C and lasted for 2–3 years. We propose that the upper troposphere/lower stratosphere aerosols from Laki disrupted the thermal balance of the Arctic regions for two summers and were the main mechanism for the associated climate perturbations. Eruptions of Laki magnitude have occurred in the recent past in Iceland and will occur again. If such an eruption were to occur today, one of the most likely immediate consequences would be disruption to air traffic over large portions of the Northern Hemisphere.

A Theory for the Indian Ocean Dipole–Zonal Mode*

Abstract: Four fundamental differences of air–sea interactions between the tropical Pacific and Indian Oceans are identified based on observational analyses and physical reasoning. The first difference is represented by the strong contrast of a zonal cloud–SST phase relationship between the warm and cool oceans. The in-phase cloud–SST relationship in the warm oceans leads to a strong negative feedback, while a significant phase difference in the cold tongue leads to a much weaker thermodynamic damping. The second difference arises from the reversal of the basic-state zonal wind and the tilting of the ocean thermocline, which leads to distinctive effects of ocean waves. The third difference lies in the existence of the Asian monsoon and its interaction with the adjacent oceans. The fourth difference is that the southeast Indian Ocean is a region where a positive atmosphere–ocean thermodynamic feedback exists in boreal summer. A conceptual coupled atmosphere–ocean model was constructed aimed to understand th...

Morphology and Composition of the Surface of Mars: Mars Odyssey THEMIS Results

Abstract: The Thermal Emission Imaging System (THEMIS) on Mars Odyssey has produced infrared to visible wavelength images of the martian surface that show lithologically distinct layers with variable thickness, implying temporal changes in the processes or environments during or after their formation. Kilometer-scale exposures of bedrock are observed; elsewhere airfall dust completely mantles the surface over thousands of square kilometers. Mars has compositional variations at 100-meter scales, for example, an exposure of olivine-rich basalt in the walls of Ganges Chasma. Thermally distinct ejecta facies occur around some craters with variations associated with crater age. Polar observations have identified temporal patches of water frost in the north polar cap. No thermal signatures associated with endogenic heat sources have been identified.

Effects of habitat, wave exposure, and marine protected area status on coral reef fish assemblages in the Hawaiian archipelago

Abstract: The relationships between fish assemblages, their associated habitat, and degree of protection from fishing were evaluated over a broad spatial scale throughout the main Hawaiian islands. Most fish assemblage characteristics showed positive responses to protection whether it was physical (e.g. habitat complexity), biological (e.g. coral cover growth forms), or human-induced (e.g. marine reserves). Fish biomass was lowest in areas of direct wave exposure and highest in areas partially sheltered from swells. Higher values for fish species richness, number of individuals, biomass, and diversity were observed in locations with higher substrate complexity. Areas completely protected from fishing had distinct fish assemblages with higher standing stock and diversity than areas where fishing was permitted or areas that were partially protected from fishing. Locations influenced by customary stewardship harbored fish biomass that was equal to or greater than that of no-take protected areas. Marine protected areas in the main Hawaiian islands with high habitat complexity, moderate wave disturbance, a high percentage of branching and/or lobate coral coupled with legal protection from fishing pressure had higher values for most fish assemblage characteristics.

An ancient role for nuclear beta-catenin in the evolution of axial polarity and germ layer segregation.

Abstract: The human oncogene beta-catenin is a bifunctional protein with critical roles in both cell adhesion and transcriptional regulation in the Wnt pathway. Wnt/beta-catenin signalling has been implicated in developmental processes as diverse as elaboration of embryonic polarity, formation of germ layers, neural patterning, spindle orientation and gap junction communication, but the ancestral function of beta-catenin remains unclear. In many animal embryos, activation of beta-catenin signalling occurs in blastomeres that mark the site of gastrulation and endomesoderm formation, raising the possibility that asymmetric activation of beta-catenin signalling specified embryonic polarity and segregated germ layers in the common ancestor of bilaterally symmetrical animals. To test whether nuclear translocation of beta-catenin is involved in axial identity and/or germ layer formation in 'pre-bilaterians', we examined the in vivo distribution, stability and function of beta-catenin protein in embryos of the sea anemone Nematostella vectensis (Cnidaria, Anthozoa). Here we show that N. vectensis beta-catenin is differentially stabilized along the oral-aboral axis, translocated into nuclei in cells at the site of gastrulation and used to specify entoderm, indicating an evolutionarily ancient role for this protein in early pattern formation.

The Global Phosphorus Cycle

Abstract: Phosphorus is an essential nutrient for all life-forms It is a key player in fundamental biochemical reactions involving genetic material (DNA and RNA) and energy transfer (ATP) and in structural support of organisms provided by membranes (phospholipids) and bone (the biomineral hydroxyapatite) Photosynthetic organisms utilize dissolved phosphorus, carbon, and other essential nutrients to build their tissues using energy from the sun Biological productivity is contingent upon the availability of phosphorus to these simple organisms that constitute the base of the food web in both terrestrial and aquatic systems It begins with a brief overview of the various components of the global phosphorus cycle Estimates of the mass of important phosphorus reservoirs, transport rates (fluxes) between reservoirs Following the overview, various aspects of the global phosphorus cycle are examined in more depth, including a discussion of the most pressing research questions currently being posed and research efforts presently underway to address these questions

A pooled analysis of case-control studies of thyroid cancer: cigarette smoking and consumption of alcohol, coffee, and tea.

Abstract: Objective: To analyze the role of smoking, alcohol, coffee and tea in relation to thyroid cancer, we conducted a pooled analysis of 14 case–control studies conducted in the United States, Europe, and Asia. Methods: The sample consisted of 2725 thyroid cancer cases (2247 females, 478 males) and 4776 controls (3699 females, 1077 males). Conditional logistic regression with stratification on study, age at diagnosis, and gender was used to compute odds ratios and 95% confidence intervals. Results: Thyroid cancer risk was reduced in persons who had ever smoked. The relationship was more pronounced in current smokers (OR = 0.6, 95% CI = 0.6–0.7) than former smokers (OR = 0.9, 95% CI = 0.8–1.1). There were significant trends of reduced risk with greater duration and frequency of smoking. For consumption of wine and beer, there was a significant trend of decreasing thyroid cancer risk (p = 0.02) that was not maintained after adjustment for current smoking (p = 0.12). Thyroid cancer risk was not associated with consumption of coffee or tea. These findings were consistent in both gender-specific and histology-specific (papillary and follicular) analyses. Conclusions: Pooled analyses of these geographically diverse case–control data indicate a reduced thyroid cancer risk associated with current smoking. A reduced risk associated with alcohol was eliminated after adjustment for smoking, and caffeinated beverages did not alter thyroid cancer risk.

Landslide tsunami case studies using a Boussinesq model and a fully nonlinear tsunami generation model

Abstract: . Case studies of landslide tsunamis require integration of marine geology data and interpretations into numerical simulations of tsunami attack. Many landslide tsunami generation and propagation models have been proposed in recent time, further motivated by the 1998 Papua New Guinea event. However, few of these models have proven capable of integrating the best available marine geology data and interpretations into successful case studies that reproduce all available tsunami observations and records. We show that nonlinear and dispersive tsunami propagation models may be necessary for many landslide tsunami case studies. GEOWAVE is a comprehensive tsunami simulation model formed in part by combining the Tsunami Open and Progressive Initial Conditions System (TOPICS) with the fully non-linear Boussinesq water wave model FUNWAVE. TOPICS uses curve fits of numerical results from a fully nonlinear potential flow model to provide approximate landslide tsunami sources for tsunami propagation models, based on marine geology data and interpretations. In this work, we validate GEOWAVE with successful case studies of the 1946 Unimak, Alaska, the 1994 Skagway, Alaska, and the 1998 Papua New Guinea events. GEOWAVE simulates accurate runup and inundation at the same time, with no additional user interference or effort, using a slot technique. Wave breaking, if it occurs during shoaling or runup, is also accounted for with a dissipative breaking model acting on the wave front. The success of our case studies depends on the combination of accurate tsunami sources and an advanced tsunami propagation and inundation model.

Asian Cultural Values, Attitudes toward Seeking Professional Psychological Help, and Willingness to See a Counselor:

Abstract: The purpose of this study was to examine the relationships among Asian American adherence to Asian cultural values, attitudes toward seeking professional psychological help, and willingness to see a counselor. Based on the data from 242 Asian American college students, the results revealed that adherence to Asian cultural values inversely predicted both attitudes toward seeking professional psychological help and general willingness to see a counselor, above and beyond the effects of related demographic variables. The results also indicated that attitudes toward seeking professional psychological help were a perfect mediator on the relationship between adherence to Asian cultural values and willingness to see a counselor in general and between adherence to Asian values and willingness to see a counselor for personal and health problems in particular.

The deep-sea floor ecosystem: current status and prospects of anthropogenic change by the year 2025

Abstract: The goal of this paper is to review current impacts of human activities on the deep-sea floor ecosystem, and to predict anthropogenic changes to this ecosystem by the year 2025. The deep-sea floor ecosystem is one of the largest on the planet, covering roughly 60% of the Earth's solid surface. Despite this vast size, our knowledge of the deep sea is poor relative to other marine ecosystems, and future human threats are difficult to predict. Low productivity, low physical energy, low biological rates, and the vastness of the soft-sediment deep sea create an unusual suite of conservation challenges relative to shallow water. The numerous, but widely spaced, island habitats of the deep ocean (for example seamounts, hydrothermal vents and submarine canyons) differ from typical deep-sea soft sediments in substrate type (hard) and levels of productivity (often high); these habitats will respond differently to anthropogenic impacts and climate change. The principal human threats to the deep sea are the disposal of wastes (structures, radioactive wastes, munitions and carbon dioxide), deep-sea fishing, oil and gas extraction, marine mineral extraction, and climate change. Current international regulations prohibit deep-sea dumping of structures, radioactive waste and munitions. Future disposal activities that could be significant by 2025 include deep-sea carbon-dioxide sequestration, sewage-sludge emplacement and dredge-spoil disposal. As fish stocks dwindle in the upper ocean, deep-sea fisheries are increasingly targeted. Most (perhaps all) of these deep-sea fisheries are not sustainable in the long term given current management practices; deep-sea fish are long-lived, slow growing and very slow to recruit in the face of sustained fishing pressure. Oil and gas exploitation has begun, and will continue, in deep water, creating significant localized impacts resulting mainly from accumulation of contaminated drill cuttings. Marine mineral extraction, in particular manganese nodule mining, represents one of the most significant conservation challenges in the deep sea. The vast spatial scales planned for nodule mining dwarf other potential direct human impacts. Nodule-mining disturbance will likely affect tens to hundreds of thousands of square kilometres with ecosystem recovery requiring many decades to millions of years (for nodule regrowth). Limited knowledge of the taxonomy, species structure, biogeography and basic natural history of deep-sea animals prevents accurate assessment of the risk of species extinctions from large-scale mining. While there are close linkages between benthic, pelagic and climatic processes, it is difficult to predict the impact of climate change on deep-sea benthic ecosystems; it is certain, however, that changes in primary production in surface waters will alter the standing stocks in the food-limited, deep-sea benthic. Long time-series studies from the abyssal North Pacific and North Atlantic suggest that even seemingly stable deep-sea ecosystems may exhibit change in key ecological parameters on decadal time scales. The causes of these decadal changes remain enigmatic. Compared to the rest of the planet, the bulk of the deep sea will probably remain relatively unimpacted by human activities and climate change in the year 2025. However, increased pressure on terrestrial resources will certainly lead to an expansion of direct human activities in the deep sea, and to direct and indirect environmental impacts. Because so little is known about this remote environment, the deep-sea ecosystem may well be substantially modified before its natural state is fully understood.

Incremental validity of new clinical assessment measures.

Abstract: The authors address conceptual and methodological foundations of incremental validity in the evaluation of newly developed clinical assessment measures. Incremental validity is defined as the degree to which a measure explains or predicts a phenomenon of interest, relative to other measures. Incremental validity can be evaluated on several dimensions, such as sensitivity to change, diagnostic efficacy, content validity, treatment design and outcome, and convergent validity. Indices of incremental validity can vary depending on the criterion measures, comparison measures, and individual differences in samples. The authors review the rationale for, principles, and methods of incremental validation, including the selection of comparison and criterion measures, and address data analytic strategies and the conditional nature of incremental validity evaluations in the selection of measures. Incremental validity contributes to, but is different from, cost-benefits, which reflect the cost of acquiring the data and the benefits from the data. The impact of an incremental validity index on whether a measure is selected will be moderated by the cost of acquiring the new data, the importance of the measured phenomenon, and the clinical utility of the new data.

Coupling between Northward-Propagating, Intraseasonal Oscillations and Sea Surface Temperature in the Indian Ocean*

Abstract: Using a hybrid atmosphere‐ocean coupled model, it is shown that during the boreal summer northwardpropagating, intraseasonal oscillations (NPISOs) are strongly coupled to the underlying sea surface temperature (SST) in the Indian Ocean sector. On the one hand, the intraseasonal atmospheric convection changes the SST through solar radiation, latent heat flux, and mixed-layer entrainment; on the other, the induced SST fluctuations feed back to affect the intraseasonal convection. The preferential northward, rather than southward, propagation of boreal summer ISOs in the Indian Ocean is partially explained by an interaction among the summer-mean climate state, the atmospheric disturbances, and the ocean surface temperature. A solution to an atmosphere-only model forced with daily SST produces much stronger NPISOs than a similar solution forced with monthly mean SST (AMIP-type run). The atmosphere-only model, however, even when it is forced by daily SST from the coupled model (with a small amount of noise in the initial and/or boundary conditions), is unable to reproduce the NPISOs in the coupled case. In the coupled system, intraseasonal SST anomalies are forced by intraseasonal atmospheric convection, and hence are in quadrature with the convection. In the stand-alone atmospheric model, however, SST acts only as a boundary forcing, and the resultant atmospheric convection has almost the same phase with the underlying SST. One consequence is that the intensity of the SST-forced intraseasonal convection in the stand-alone atmospheric model is considerably weaker than in the coupled model. Finally, solutions indicate that the northward movement of the off-equatorial convection in the northern Indian Ocean is more closely related to local intraseasonal SST anomalies than to the equatorial eastward-moving Madden‐Julian oscillation: Positive (negative) SST anomalies in the northern Indian Ocean lead the active (break) phases of the intraseasonal convection by about 2 pentads (10 days). Therefore, intraseasonal SST anomalies in the northern Indian Ocean are potentially a useful index to forecast active (break) spells of the south Asian summer monsoon.

Global morphology of infrasound propagation

Abstract: [i] Atmospheric sound waves in the 0.02-10 Hz region, also known as infrasound, exhibit long-range global propagation characteristics. Measurable infrasound is produced around the globe on a daily basis by a variety of natural and man-made sources. As a result of weak classical attenuation (∼0.01 dB km -1 at 0.1 hz), these acoustic signals can propagate thousands of kilometers in tropospheric, stratospheric, and lower thermospheric ducts. To model this propagation accurately, detailed knowledge of the background atmospheric state variables, the global winds and temperature fields from the ground to ∼170 km, is required. For infrasound propagation calculations, we have developed a unique atmospheric specification system (G2S) that is capable of providing this information. Using acoustic ray tracing methods and detailed G2S atmospheric specifications, we investigate the major aspects of the spatiotemporal variability of infrasound propagation characteristics.

Homotopy analysis of nonlinear progressive waves in deep water

Abstract: This paper describes the application of a recently developed analytic approach known as the homotopy analysis method to derive a solution for the classical problem of nonlinear progressive waves in deep water. The method is based on a continuous variation from an initial trial to the exact solution. A Maclaurin series expansion provides a successive approximation of the solution through repeated application of a differential operator with the initial trial as the first term. This approach does not require the use of perturbation parameters and the solution series converges rapidly with the number of terms. In the framework of this approach, a new technique to apply the Pade expansion is implemented to further improve the convergence. As a result, the calculated phase speed at the 20th-order approximation of the solution agrees well with previous perturbation solutions of much higher orders and reproduces the well-known characteristics of being a non-monotonic function of wave steepness near the limiting condition.

Strong El Niño events and nonlinear dynamical heating

Abstract: [1] We present evidence showing that the nonlinear dynamic heating (NDH) in the tropical Pacific ocean heat budget is essential in the generation of intense El Nino events as well as the observed asymmetry between El Nino (warm) and La Nina (cold) events. The increase in NDH associated with the enhanced El Nino activity had an influence on the recent tropical Pacific warming trend and it might provide a positive feedback mechanism for climate change in the tropical Pacific.

Kuroshio Extension Variability and Forcing of the Pacific Decadal Oscillations: Responses and Potential Feedback

Abstract: A forcing mechanism is sought for the large-scale circulation changes in the Kuroshio Extension region of the western North Pacific Ocean as inferred by TOPEX/Poseidon sea surface height (SSH) data. The low-frequency signal of the Kuroshio Extension over the last decade was characterized by a modulation in its zonal mean flow intensity: the mean Kuroshio Extension jet weakened progressively from 1993 to 1996 and this trend reversed after 1997. The ability to simulate the major trends in the observed SSH signals with linear vorticity dynamics leads the authors to conclude that the modulation in the zonal mean jet was remotely forced by wind stress curl anomalies in the eastern North Pacific Ocean related to the Pacific decadal oscillations (PDOs). To be specific, the weakening (strengthening) trend in 1993–96 (1997–2001) was caused by westward expansions of negative (positive) SSH anomalies south of the Kuroshio Extension and positive (negative) SSH anomalies north of the Kuroshio Extension. Emerg...

Observation of a near-threshold enhancement in the pp mass spectrum from radiative J/psi-->gammapp decays.

Abstract: We observe a narrow enhancement near 2m(p) in the invariant mass spectrum of pp pairs from radiative J/psi-->gammapp decays. No similar structure is seen in J/psi-->pi(0)pp decays. The results are based on an analysis of a 58 x 10(6) event sample of J/psi decays accumulated with the BESII detector at the Beijing electron-positron collider. The enhancement can be fit with either an S- or P-wave Breit-Wigner resonance function. In the case of the S-wave fit, the peak mass is below 2m(p) at M=1859(+3)(-10) (stat)+5-25(syst) MeV/c(2) and the total width is Gamma<30 MeV/c(2) at the 90% confidence level. These mass and width values are not consistent with the properties of any known particle.

Covariations of Sea Surface Temperature and Wind over the Kuroshio and Its Extension: Evidence for Ocean-to-Atmosphere Feedback(.

Abstract: Satellite microwave measurements are analyzed, revealing robust covariability in sea surface temperature (SST) and wind speed over the Kuroshio Extension (KE) east of Japan. Ocean hydrodynamic instabilities cause the KE to meander and result in large SST variations. Increased (reduced) wind speeds are found to be associated with warm (cold) SST anomalies. This positive SST–wind correlation in KE is confirmed by in situ buoy measurements and is consistent with a vertical shear adjustment mechanism. Namely, an increase in SST reduces the static stability of the near-surface atmosphere, intensifying the vertical turbulence mixing and bringing fast-moving air from aloft to the sea surface. South of Japan, the Kuroshio is known to vary between nearshore and offshore paths. These paths are very persistent and can last for months to years. As the Kuroshio shifts its path, coherent wind changes are detected from satellite data. In particular, winds are high south of Tokyo when the Kuroshio takes the near...

An Empirical Criterion to Classify T Tauri Stars and Substellar Analogs Using Low-Resolution Optical Spectroscopy

Abstract: We have compiled and studied photometric and spectroscopic data published in the literature of several star-forming regions and young open clusters (Orion, Taurus, IC 348, Sco-Cen complex, Chamaeleon I, TW Hydrae association, σ Orionis cluster, IC 2391, α Persei cluster, and the Pleiades) Our goal was to seek the definition of a simple empirical criterion to classify stars or brown dwarfs that are accreting matter from a disk on the sole basis of low-resolution optical spectroscopic data We show that, using Hα equivalent widths and spectral types, we can statistically classify very young stars and brown dwarfs as classical T Tauri stars and substellar analogs As a boundary between accreting and nonaccreting objects, we use the saturation limit of chromospheric activity at log [L(Hα)/L(bol)] = -33 (determined in the open clusters) We discuss the uncertainties in the classification scheme due to the occurrence of flares We have used this spectroscopic empirical criterion to classify objects found in the literature, and we compute the fraction of accreting objects in several star-forming regions The fraction of accreting objects appears to decrease from about 50% to about 5% from 1 to 10 Myr for both stars and brown dwarfs

Evaluation of Human Serum Albumin Cobalt Binding Assay for the Assessment of Myocardial Ischemia and Myocardial Infarction

Abstract: Background: Clinical diagnoses were correlated with results of a Co(II)–albumin binding assay in 167 patients treated at an emergency department of a health maintenance organization. Methods: Patients were evaluated as being nonischemic or potentially ischemic through standard coronary disease indicators [creatine kinase (CK), CK-MB, cardiac troponin I, and electrocardiographic findings] and were tested by a Co(II)–albumin binding assay. Samples were tested anonymously, and the study was double-blinded. The sensitivity and specificity of this assay for the detection of ischemia were evaluated by ROC curve analysis. Known Co(II) binding sites on albumin were analyzed by N-terminal amino acid sequencing. Results: The mean absorbance units (ABSU) ± 2 SD for non-myocardial ischemic and myocardial ischemic individuals measured at 470 nm were 0.43 ± 0.10 and 0.63 ± 0.25, respectively ( P <0.0001). The area under the ROC curve was 0.95 [95% confidence interval (CI), 0.92–0.99], and at a cutoff value of 0.50 ABSU, sensitivity and specificity were 88% (78–94%) and 94% (86–98%), respectively, suggesting a high distinction between the two groups. When we compared non-acute myocardial infarction (AMI) and AMI ischemic individuals, the area under the ROC curve was 0.66 (95% CI, 0.53–0.79) and was considered a poor discriminator between these two groups. N-Terminal amino acid sequencing data for purified albumin showed normal amino acid residues for six of seven high-ABSU (≥0.70) individuals and one nonischemic individual tested. However, only one individual with a high ABSU (0.80) had two missing amino acid residues (DA) from the N-terminal region. Clinical diagnosis for this patient did not reveal an ischemic event. Conclusions: The Co(II)–albumin binding test may serve as a useful diagnostic tool in emergency facilities for the assessment of myocardial ischemia. High and low ABSU were associated with myocardial ischemic individuals and non-myocardial ischemic individuals, respectively. However, the Co(II)–albumin binding was a poor discriminator between ischemic individuals with and without MI.