University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

Future Changes in Tropical Cyclone Activity Projected by the New High-Resolution MRI-AGCM*

Abstract: New versions of the high-resolution 20- and 60-km-mesh Meteorological Research Institute (MRI) atmospheric general circulation models (MRI-AGCM version 3.2) have been developed and used to investigate potential future changes in tropical cyclone (TC) activity. Compared with the previous version (version 3.1), version 3.2 yields a more realistic simulation of the present-day (1979–2003) global distribution of TCs. Moreover, the 20-km-mesh model version 3.2 is able to simulate extremely intense TCs (categories 4 and 5), which is the first time a global climate model has been able to simulate such extremely intense TCs through a multidecadal simulation. Future (2075–99) projections under the Intergovernmental Panel on Climate Change (IPCC) A1B scenario are conducted using versions 3.1 and 3.2, showing consistent decreases in the number of TCs globally and in both hemispheres as climate warms. Although projected future changes in basin-scale TC numbers show some differences between the two versions, t...

The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

Abstract: Background: We describe the genome of the western painted turtle, Chrysemys picta bellii, one of the most widespread, abundant, and well-studied turtles. We place the genome into a comparative evolutionary context, and focus on genomic features associated with tooth loss, immune function, longevity, sex differentiation and determination, and the species’ physiological capacities to withstand extreme anoxia and tissue freezing. Results: Our phylogenetic analyses confirm that turtles are the sister group to living archosaurs, and demonstrate an extraordinarily slow rate of sequence evolution in the painted turtle. The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks, and we identify candidate genes for future functional analyses. Tooth loss shares a common pattern of pseudogenization and degradation of tooth-specific genes with birds, although the rate of accumulation of mutations is much slower in the painted turtle. Genes associated with sex differentiation generally reflect phylogeny rather than convergence in sex determination functionality. Among gene families that demonstrate exceptional expansions or show signatures of strong natural selection, immune function and musculoskeletal patterning genes are consistently over-represented. Conclusions: Our comparative genomic analyses indicate that common vertebrate regulatory networks, some of which have analogs in human diseases, are often involved in the western painted turtle’s extraordinary physiological capacities. As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders.