University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

Fungal infections in HIV/AIDS

Abstract: Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or represent with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both. Affordable, rapid point-of-care diagnostic tests (as have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and histoplasmosis. Additionally, antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available. Such measures, together with continued international efforts in education and training in the management of fungal disease, have the potential to improve patient outcomes substantially.

The continuing spread of West Nile virus in the western hemisphere.

Abstract: West Nile virus (WNV) has historically been considered to be among the least virulent of the Japanese serogroup viruses of the family Flaviviridae, genus Flavivirus. However, recent epidemics associated with severe and fatal neuroinvasive disease have changed that perception. The emergence of a virus subtype with greater epidemic potential and virulence in the early 1990s facilitated the geographic expansion and westward spread of WNV; in 1999, it first appeared in the western hemisphere. Because of the broad host and vector range, the virus has become established in much of the region, and there is little chance that it will be eliminated. Transmission is difficult to predict and even more difficult to prevent and control. The cost-effectiveness of human WNV vaccines is uncertain. The building of laboratory diagnostic, epidemiologic, and vector-control capacity in WNV-enzootic countries is critical to the development of effective prevention and control strategies for WNV infection, as well as for other potential emerging vectorborne viral diseases.

Infrared Spectral Energy Distributions of Nearby Galaxies

Abstract: The Spitzer Infrared Nearby Galaxies Survey (SINGS) is carrying out a comprehensive multiwavelength survey on a sample of 75 nearby galaxies. The 1-850 μm spectral energy distributions (SEDs) are presented using broadband imaging data from Spitzer, 2MASS, ISO, IRAS, and SCUBA. The infrared colors derived from the globally integrated Spitzer data are generally consistent with the previous generation of models that were developed using global data for normal star-forming galaxies, although significant deviations are observed. Spitzer's excellent sensitivity and resolution also allow a detailed investigation of the infrared SEDs for various locations within the three large, nearby galaxies NGC 3031 (M81), NGC 5194 (M51), and NGC 7331. A wide variety of spectral shapes is found within each galaxy, especially for NGC 3031, the closest of the three targets and thus the galaxy for which the smallest spatial scales can be explored. Strong correlations exist between the local star formation rate and the infrared colors fν(70 μm)/fν(160 μm) and fν(24 μm)/fν(160 μm), suggesting that the 24 and 70 μm emission are useful tracers of the local star formation activity level. Preliminary evidence indicates that variations in the 24 μm emission, and not variations in the emission from polycyclic aromatic hydrocarbons at 8 μm, drive the variations in the fν(8.0 μm)/fν(24 μm) colors within NGC 3031, NGC 5194, and NGC 7331. If the galaxy-to-galaxy variations in SEDs seen in our sample are representative of the range present at high redshift, then extrapolations of total infrared luminosities and star formation rates from the observed 24 μm flux will be uncertain at the factor of 5 level (total range). The corresponding uncertainties using the redshifted 8.0 μm flux (e.g., observed 24 μm flux for a z = 2 source) are factors of 10-20. Considerable caution should be used when interpreting such extrapolated infrared luminosities.