Institution
University of Hawaii at Manoa
Education•Honolulu, Hawaii, United States•
About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.
Papers published on a yearly basis
Papers
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TL;DR: Wang et al. as discussed by the authors found that Chinese mothers who had high scores for both authoritative and authoritarian parenting styles adhered most strongly to the Chinese cultur... and other characteristics of the family contexts, such as perceived parenting distress, social support, and years of education, also contributed to Chinese mothers' parenting styles.
Abstract: Parenting styles and mother-child interaction were examined with 97 Mainland Chinese mothers (M age = 29.64 years, SD = 3.64) and their young children (M = 24.30 months, SD = 4.57). Mothers completed questionnaires about their parenting styles, orientation to Chinese cultural values, perceived parenting stress, and sources of social support. The regression analyses showed that mothers' adherence to Chinese values was associated with both authoritative and authoritarian parenting styles. Other characteristics of the family contexts, such as perceived parenting distress, social support, and years of education, also contributed to Chinese mothers' parenting styles. Mother-child dysfunctional interaction was associated with mothers' heightened parenting distress, a lack of perceived social support, and perceptions of children's difficultness. Group comparisons revealed that Chinese mothers who had high scores for both authoritative and authoritarian parenting styles adhered most strongly to the Chinese cultur...
242 citations
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TL;DR: Targeting HIF-1 during wound healing has many important clinical implications for tissue repair and counteracting the detrimental effects of excessive or deficient Hif-1 signaling by modulating H IF-1 expression may improve future management of poorly healing wounds.
Abstract: Significance: Poor wound healing remains a significant health issue for a large number of patients in the United States. The physiologic response to local wound hypoxia plays a critical role in determining the success of the normal healing process. Hypoxia-inducible factor-1 (HIF-1), as the master regulator of oxygen homeostasis, is an important determinant of healing outcomes. HIF-1 contributes to all stages of wound healing through its role in cell migration, cell survival under hypoxic conditions, cell division, growth factor release, and matrix synthesis throughout the healing process. Recent Advances: Positive regulators of HIF-1, such as prolyl-4-hydroxylase inhibitors, have been shown to be beneficial in enhancing diabetic ischemic wound closure and are currently undergoing clinical trials for treatment of several human-ischemia-based conditions. Critical Issues: HIF-1 deficiency and subsequent failure to respond to hypoxic stimuli leads to chronic hypoxia, which has been shown to contribute to the formation of nonhealing ulcers. In contrast, overexpression of HIF-1 has been implicated in fibrotic disease through its role in increasing myofibroblast differentiation leading to excessive matrix production and deposition. Both positive and negative regulators of HIF-1 therefore provide important therapeutic targets that can be used to manipulate HIF-1 expression where an excess or deficiency in HIF-1 is known to correlate with pathogenesis. Future Directions: Targeting HIF-1 during wound healing has many important clinical implications for tissue repair. Counteracting the detrimental effects of excessive or deficient HIF-1 signaling by modulating HIF-1 expression may improve future management of poorly healing wounds.
242 citations
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TL;DR: A review of observational data and model results concludes that vertical mixing determines the physical properties of water in the Indonesian throughflow as mentioned in this paper, and the Indonesian seas provide the only connection between ocean basins in the tropics.
Abstract: The Indonesian seas provide the only connection between ocean basins in the tropics. A review of observational data and model results concludes that vertical mixing determines the physical properties of water in the Indonesian throughflow.
241 citations
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Columbia University1, Harvard University2, University of Minnesota3, City of Hope National Medical Center4, Maastricht University5, American Cancer Society6, University of Melbourne7, University at Buffalo8, Brigham and Women's Hospital9, Cancer Prevention Institute of California10, Karolinska Institutet11, United States Department of Health and Human Services12, University of Regensburg13, National Institute for Health and Welfare14, University of Toronto15, Albert Einstein College of Medicine16, National Institutes of Health17, University of Hawaii at Manoa18, The Queen's Medical Center19
TL;DR: In this article, a pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up and a positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95% CI = 109-1.78).
Abstract: Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2) , pancreatic cancer risk was 47% higher (95%CI:23-75%) among obese (BMI ≥ 30 kg/m(2) ) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI ≥ 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2) ). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2) ) and not obese at baseline (BMI < 30 kg/m(2) ), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.
241 citations
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TL;DR: This study describes spatial patterns in Honolulu motor vehicle accidents for 1990 and shows that these conditions spatially correlate with single-vehicle crashes and crashes with opposite direction vehicles, point to the limits of "blackspot" analysis.
240 citations
Authors
Showing all 13867 results
Name | H-index | Papers | Citations |
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Pulickel M. Ajayan | 176 | 1223 | 136241 |
Steven N. Blair | 165 | 879 | 132929 |
Qiang Zhang | 161 | 1137 | 100950 |
Jack M. Guralnik | 148 | 453 | 83701 |
Thomas J. Smith | 140 | 1775 | 113919 |
James A. Richardson | 136 | 363 | 75778 |
Donna Neuberg | 135 | 810 | 72653 |
Jian Zhou | 128 | 3007 | 91402 |
Eric F. Bell | 128 | 631 | 72542 |
Jorge Luis Rodriguez | 128 | 834 | 73567 |
Bin Wang | 126 | 2226 | 74364 |
Nicholas J. Schork | 125 | 587 | 62131 |
Matthew Jones | 125 | 1161 | 96909 |
Anthony F. Jorm | 124 | 798 | 67120 |
Adam G. Riess | 118 | 363 | 117310 |