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Institution

University of Hawaii at Manoa

EducationHonolulu, Hawaii, United States
About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.


Papers
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Journal ArticleDOI
TL;DR: Substantia nigra neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu‐Asia Aging Study and there was a significant association of increasing number of signs present with decreasing neuron density in both quadrants.
Abstract: Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu-Asia Aging Study, aged 74-97 years at death. Quadrants areas within the SN were determined with a planimeter and neuronal density was expressed as neurons/mm(2) for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body cases, and 178 controls with neither condition. Mean densities in all quadrants were significantly lower in the PD group compared with the other groups (p = 0.006). This relationship was strongest in the ventrolateral quadrant. In a subgroup of 50 controls who were examined with the Unified Parkinson's Disease Rating Scale an average of 2.1 years prior to death, there was an association of stooped posture (p = 0.009), postural instability (p = 0.013), body bradykinesia (p = 0.048), and gait disturbance (p = 0.05) with neuron density in the dorsolateral quadrant; and impaired speech (p = 0.014), abnormal facial expression (p = 0.022), and difficulty rising from a chair (p = 0.032) with neuron density in the dorsomedial quadrant. There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD.

223 citations

Journal ArticleDOI
TL;DR: A set of polymerase chain reaction primers were designed, which amplify a c .
Abstract: A set of polymerase chain reaction primers were designed, which amplify a c . 1 kb fragment of the 18S ribosomal DNA gene, and are specific to the phylum Nematoda. These have proven useful in isolating nematode genes from samples mixed with other biological material, particularly with application to DNA barcoding. Optimal reaction conditions are described. These primers have successfully amplified the correct fragment from a wide phylogenetic range of nematodes, and have so far generated no sequences from any other organismal group.

223 citations

Journal ArticleDOI
TL;DR: More hypothesis-driven and rigorous clinical trial designs are needed to help clarify the true potential utility of antioxidants in CVD and may lead to a better understanding of the role of oxidative stress in atherosclerosis.
Abstract: The free radical theory of aging posits that oxidative stress is among the major mechanisms in aging and age-related disease, including cardiovascular disease (CVD) Numerous in vitro and animal studies have supported the role of low-density lipoprotein (LDL) oxidation in atherosclerosis This has led to the hypothesis that antioxidants could be used as an inexpensive means of prevention and possibly, treatment of coronary artery disease, stroke, peripheral vascular disease, and other CVD-related diseases Epidemiologic cohort studies with large numbers of men, women, and diverse populations have been largely supportive of this hypothesis However, interventional trials have been controversial, with some positive findings, many null findings, and some suggestion of harm in certain high-risk populations Because of the mismatch between the epidemiologic studies and the interventional trials, some researchers have advocated ending antioxidant work Others have questioned the validity of the LDL oxidative hypothesis itself Clearly, further research is needed to understand the reasons for the mismatch between the epidemiologic and interventional work Recent smaller interventional studies with carefully chosen populations, such as those under high levels of oxidative stress, have yielded largely positive results This suggests that we need more hypothesis-driven and rigorous clinical trial designs This should help clarify the true potential utility of antioxidants in CVD and may lead to a better understanding of the role of oxidative stress in atherosclerosis

222 citations

Journal ArticleDOI
TL;DR: DNA methylation biomarkers associated with PrCa are identified and the findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.
Abstract: It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.

222 citations

Journal ArticleDOI
Kelly L. Bolton1, Kelly L. Bolton2, Jonathan Tyrer2, Honglin Song2, Susan J. Ramus3, Maria Notaridou3, Chris Jones3, Tanya Sher3, Aleksandra Gentry-Maharaj3, Eva Wozniak3, Ya-Yu Tsai4, Joanne B. Weidhaas5, Daniel Paik5, David Van Den Berg6, Daniel O. Stram6, Celeste Leigh Pearce6, Anna H. Wu6, Wendy R. Brewster7, Hoda Anton-Culver7, Argyrios Ziogas8, Steven A. Narod9, Douglas A. Levine9, Stanley B. Kaye, Robert S. Brown10, James Paul11, James M. Flanagan10, Weiva Sieh12, Valerie McGuire12, Alice S. Whittemore12, Ian G. Campbell13, Martin Gore14, Jolanta Lissowska15, Hanna P. Yang1, Krzysztof Mędrek16, Jacek Gronwald16, Jan Lubinski16, Anna Jakubowska16, Nhu D. Le17, Linda S. Cook18, Linda S. Cook19, Linda E. Kelemen19, Angela Brook-Wilson20, Angela Brook-Wilson17, Leon F.A.G. Massuger21, Lambertus A. Kiemeney21, Katja K.H. Aben, Anne M. van Altena21, Richard S. Houlston, Ian Tomlinson22, Rachel T. Palmieri23, Patricia G. Moorman23, Joellen M. Schildkraut23, Edwin S. Iversen23, Catherine M. Phelan4, Robert A. Vierkant24, Julie M. Cunningham24, Ellen L. Goode24, Brooke L. Fridley24, Susan Kruger-Kjaer, Jan Blaeker25, Estrid Høgdall, Claus Høgdall26, Jenny Gross27, Beth Y. Karlan27, Roberta B. Ness28, Robert P. Edwards29, Kunle Odunsi30, Kirsten B. Moyisch30, Julie A. Baker31, Francesmary Modugno29, Tuomas Heikkinenen32, Ralf Bützow32, Heli Nevanlinna32, Arto Leminen32, Natalia Bogdanova, Natalia Antonenkova, Thilo Doerk33, Peter Hillemanns33, Matthias Dürst34, Ingo B. Runnebaum34, Pamela J. Thompson35, Michael E. Carney35, Marc T. Goodman35, Galina Lurie35, Shan Wang-Gohrke36, Rebecca Hein37, Jenny Chang-Claude37, Mary Anne Rossing38, Kara L. Cushing-Haugen38, Jennifer A. Doherty38, Chu Chen38, Thorunn Rafnar39, Søren Besenbacher39, Patrick Sulem39, Kari Stefansson39, Michael J. Birrer40, Kathryn L. Terry40, Dena G. Hernandez1, Daniel W. Cramer40, Ignace Vergote41, Frédéric Amant41, Diether Lambrechts41, Evelyn Despierre41, Peter A. Fasching42, Matthias W. Beckmann15, Falk Thiel43, Arif B. Ekici43, Xiaoqing Chen44, Sharon E. Johnatty44, Penelope M. Webb44, Jonathan Beesley44, Stephen J. Chanock1, Montserrat Garcia-Closas1, T A Sellers4, Douglas F. Easton2, Andrew Berchuck23, Georgia Chenevix-Trench44, Paul D.P. Pharoah2, Simon A. Gayther3 
TL;DR: In this article, a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of susceptibility showed evidence of association with survival.
Abstract: Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women(1) We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility Two SNPs at 19p1311, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 x 10(-4) and P = 6 x 10(-4), respectively), but they did not replicate in phase 3 However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 x 10(-9) and P = 4 x 10(-11), respectively) Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development

222 citations


Authors

Showing all 13867 results

NameH-indexPapersCitations
Pulickel M. Ajayan1761223136241
Steven N. Blair165879132929
Qiang Zhang1611137100950
Jack M. Guralnik14845383701
Thomas J. Smith1401775113919
James A. Richardson13636375778
Donna Neuberg13581072653
Jian Zhou128300791402
Eric F. Bell12863172542
Jorge Luis Rodriguez12883473567
Bin Wang126222674364
Nicholas J. Schork12558762131
Matthew Jones125116196909
Anthony F. Jorm12479867120
Adam G. Riess118363117310
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202362
2022244
20211,111
20201,164
20191,151
20181,154