University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

Complex organic matter in Titan's atmospheric aerosols from in situ pyrolysis and analysis

Abstract: The Huygens probe landed on Titan on 14 January this year, and seven papers published in this issue record the encounter. They describe a world that resembles a primitive Earth, complete with weather systems and geological activity. The ‘Huygens on Titan’ section opens with an overview of the descent and landing and a News and Views piece. Tomasko et al. describe the dry riverbed and drainage channels seen during Huygens' descent, evidence that liquid methane falls as rain or erupts from cryovolcanoes, periodically flooding the surface. This paper includes the images used on the cover to the Huygens section. Niemann et al. measured the abundances of isotopes of argon, nitrogen and carbon in the atmosphere, and conclude that there is no evidence that Titan's methane comes from biological activity. Fulchignoni et al. obtained precise measurements of temperature and pressure from the upper atmosphere right down to the surface. On the way down Huygens recorded evidence for lightning. Zarnecki et al. report that the probe landed on a relatively smooth surface of icy grains with the consistency of wet clay or sand. Isral et al. report that the aerosols in Titan's clouds have solid cores made from complex organic molecules containing carbon and nitrogen. And Bird et al. found that on average Titan's winds blow in the same direction as the moon rotates, and that close to the surface these winds are very weak, travelling at around walking speed. Aerosols in Titan's atmosphere play an important role in determining its thermal structure1,2,3. They also serve as sinks for organic vapours4 and can act as condensation nuclei for the formation of clouds5,6, where the condensation efficiency will depend on the chemical composition of the aerosols5,7. So far, however, no direct information has been available on the chemical composition of these particles. Here we report an in situ chemical analysis of Titan's aerosols by pyrolysis at 600 °C. Ammonia (NH3) and hydrogen cyanide (HCN) have been identified as the main pyrolysis products. This clearly shows that the aerosol particles include a solid organic refractory core. NH3 and HCN are gaseous chemical fingerprints of the complex organics that constitute this core, and their presence demonstrates that carbon and nitrogen are in the aerosols.

Lithium and Hα in stars and brown dwarfs of σ Orionis

Abstract: We present intermediate- and low-resolution optical spectra around Hα and Li I λ6708 A for a sample of 25 low mass stars and 2 brown dwarfs with confirmed membership in the pre-main sequence stellar σ Orionis cluster. Our observations are intended to investigate the age of the cluster. The spectral types derived for our target sample are found to be in the range K6–M8.5, which corresponds to a mass interval of roughly 1.2–0.02 M⊙ on the basis of state-of-the-art evolutionary models. Radial velocities (except for one object) are found to be consistent with membership in the Orion complex. All cluster members show considerable Hα emission and the Li I resonance doublet in absorption, which is typical of very young ages. We find that our pseudo-equivalent widths of Hα and Li I (measured relative to the observed local pseudo-continuum formed by molecular absorptions) appear rather dispersed (and intense in the case of Hα) for objects cooler than M3.5 spectral class, occurring at the approximate mass where low mass stars are expected to become fully convective. The least massive brown dwarf in our sample, S Ori 45 (M8.5, ~0.02 M⊙), displays variable Hα emission and a radial velocity that differs from the cluster mean velocity. Tentative detection of forbidden lines in emission indicates that this brown dwarf may be accreting mass from a surrounding disk. We also present recent computations of Li I λ6708 A curves of growth for low gravities and for the temperature interval (about 4000–2600 K) of our sample. The comparison of our observations to these computations allows us to infer that no lithium depletion has yet taken place in σ Orionis, and that the observed pseudo-equivalent widths are consistent with a cluster initial lithium abundance close to the cosmic value. Hence, the upper limit to the σ Orionis cluster age can be set at 8 Myr, with a most likely value around 2–4 Myr.

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Abstract: In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Preserving accuracy in GenBank

Abstract: GenBank, the public repository for nucleotide and protein sequences, is a critical resource for molecular biology, evolutionary biology, and ecology. While some attention has been drawn to sequence errors ([1][1]), common annotation errors also reduce the value of this database. In fact, for