University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

Future changes in tropical cyclone activity projected by multi-physics and multi-SST ensemble experiments using the 60-km-mesh MRI-AGCM

Abstract: Uncertainties in projected future changes in tropical cyclone (TC) activity are investigated using future (2075–2099) ensemble projections of global warming under the Intergovernmental Panel on Climate Change (IPCC) A1B scenario. Twelve ensemble experiments are performed using three different cumulus convection schemes and four different assumptions for prescribed future sea surface temperatures (SSTs). All ensemble experiments consistently project significant reductions in global and hemispheric TC genesis numbers as well as reductions in TC frequency of occurrence (TCF) and TC genesis frequency (TGF) in the western North Pacific, South Indian Ocean, and South Pacific Ocean. TCF and TGF are projected to increase over the central Pacific which is consistent with the findings of Li et al. (2010). Inter-experimental variations of projected future changes in TGF and TC genesis number are caused mainly by differences in large-scale dynamical parameters and SST anomalies. Thermodynamic parameters are of secondary importance for variations in TGF and TC genesis number. These results imply that differences in SST spatial patterns can cause substantial variations and uncertainties in projected future changes of TGF and TC numbers at ocean-basin scales.

SIRT5 regulation of ammonia-induced autophagy and mitophagy

Abstract: In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved in ammonia production also in nonliver cells, clones of human breast cancer cell lines MDA-MB-231 and mouse myoblast C2C12, overexpressing or silenced for SIRT5 were produced. Our results show that ammonia production increased in SIRT5-silenced and decreased in SIRT5-overexpressing cells. We also obtained the same ammonia increase when using a new specific inhibitor of SIRT5 called MC3482. SIRT5 regulates ammonia production by controlling glutamine metabolism. In fact, in the mitochondria, glutamine is transformed in glutamate by the enzyme glutaminase, a reaction producing ammonia. We found that SIRT5 and glutaminase coimmunoprecipitated and that SIRT5 inhibition resulted in an increased succinylation of glutaminase. We next determined that autophagy and mitophagy were increased by ammonia by measuring autophagic proteolysis of long-lived proteins, increase of autophagy markers MAP1LC3B, GABARAP, and GABARAPL2, mitophagy markers BNIP3 and the PINK1-PARK2 system as well as mitochondrial morphology and dynamics. We observed that autophagy and mitophagy increased in SIRT5-silenced cells and in WT cells treated with MC3482 and decreased in SIRT5-overexpressing cells. Moreover, glutaminase inhibition or glutamine withdrawal completely prevented autophagy. In conclusion we propose that the role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism.

The time has come for dimensional personality disorder diagnosis

Abstract: Author(s): Hopwood, Christopher J; Kotov, Roman; Krueger, Robert F; Watson, David; Widiger, Thomas A; Althoff, Robert R; Ansell, Emily B; Bach, Bo; Michael Bagby, R; Blais, Mark A; Bornovalova, Marina A; Chmielewski, Michael; Cicero, David C; Conway, Christopher; De Clercq, Barbara; De Fruyt, Filip; Docherty, Anna R; Eaton, Nicholas R; Edens, John F; Forbes, Miriam K; Forbush, Kelsie T; Hengartner, Michael P; Ivanova, Masha Y; Leising, Daniel; John Livesley, W; Lukowitsky, Mark R; Lynam, Donald R; Markon, Kristian E; Miller, Joshua D; Morey, Leslie C; Mullins-Sweatt, Stephanie N; Hans Ormel, J; Patrick, Christopher J; Pincus, Aaron L; Ruggero, Camilo; Samuel, Douglas B; Sellbom, Martin; Slade, Tim; Tackett, Jennifer L; Thomas, Katherine M; Trull, Timothy J; Vachon, David D; Waldman, Irwin D; Waszczuk, Monika A; Waugh, Mark H; Wright, Aidan GC; Yalch, Mathew M; Zald, David H; Zimmermann, Johannes