University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

Abstract: Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles. Here we analysed 9.2 million single nucleotide polymorphisms (SNPs) in each of 8,214 Mexicans and other Latin Americans: 3,848 with type 2 diabetes and 4,366 non-diabetic controls. In addition to replicating previous findings, we identified a novel locus associated with type 2 diabetes at genome-wide significance spanning the solute carriers SLC16A11 and SLC16A13 (P = 3.9 × 10(-13); odds ratio (OR) = 1.29). The association was stronger in younger, leaner people with type 2 diabetes, and replicated in independent samples (P = 1.1 × 10(-4); OR = 1.20). The risk haplotype carries four amino acid substitutions, all in SLC16A11; it is present at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in European and African samples. Analysis of an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals. The SLC16A11 messenger RNA is expressed in liver, and V5-tagged SLC16A11 protein localizes to the endoplasmic reticulum. Expression of SLC16A11 in heterologous cells alters lipid metabolism, most notably causing an increase in intracellular triacylglycerol levels. Despite type 2 diabetes having been well studied by genome-wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

Measurement of the Flux and Zenith-Angle Distribution of Upward Throughgoing Muons by Super-Kamiokande

Abstract: A total of 614 upward throughgoing muons of minimum energy 1.6thinspthinspGeV are observed by Super-Kamiokande during 537 detector live days. The measured muon flux is [1.74{plus_minus}0.07(stat){plus_minus} 0.02(sys)]{times}10{sup {minus}13} cm{sup {minus}2}thinsps{sup {minus}1}thinspsr{sup {minus}1} compared to an expected flux of [1.97{plus_minus}0.44(theor)]{times} 10{sup {minus}13} cm{sup {minus}2}thinsps{sup {minus}1}thinspsr{sup {minus}1} . The absolute measured flux is in agreement with the prediction within the errors. However, the zenith-angle dependence of the observed upward throughgoing muon flux does not agree with no-oscillation predictions. The observed distortion in shape is consistent with the {nu}{sub {mu}}{leftrightarrow}{nu}{sub {tau}} oscillation hypothesis with sin{sup 2}thinsp2{theta} {gt}0.4 and 1{times}10{sup {minus}3}{lt}{Delta}m{sup 2}{lt}1{times}1 0{sup {minus}1} eV{sup 2} at 90{percent} confidence level. {copyright} {ital 1999} {ital The American Physical Society}

Pacific western boundary currents and their roles in climate

Abstract: Pacific Ocean western boundary currents and the interlinked equatorial Pacific circulation system were among the first currents of these types to be explored by pioneering oceanographers. The widely accepted but poorly quantified importance of these currents-in processes such as the El Nino/Southern Oscillation, the Pacific Decadal Oscillation and the Indonesian Throughflow-has triggered renewed interest. Ongoing efforts are seeking to understand the heat and mass balances of the equatorial Pacific, and possible changes associated with greenhouse-gas-induced climate change. Only a concerted international effort will close the observational, theoretical and technical gaps currently limiting a robust answer to these elusive questions.

Role of Air-Sea Interaction in the Long Persistence of El Nino-Induced North Indian Ocean Warming*

Abstract: El Nino induces a basin-wide increase in tropical Indian Ocean (TIO) sea surface temperature (SST) with a lag of one season. The north IO (NIO), in particular, displays a peculiar double-peak warming with the second peak larger in magnitude and persisting well through the summer. Motivated by recent studies suggesting the importance of the TIO warming for the Northwest Pacific and East Asian summer monsoons, the present study investigates the mechanisms for the second peak of the NIO warming using observations and general circulation models. This analysis reveals that internal air-sea interaction within the TIO is key to sustaining the TIO warming through summer. During El Nino, anticyclonic wind curl anomalies force a downwelling Rossby wave in the south TIO through Walker circulation adjustments, causing a sustained SST warming in the tropical southwest IO (SWIO) where the mean thermocline is shallow. During the spring and early summer following El Nino, this SWIO warming sustains an antisymmetric pattern of atmospheric anomalies with northeasterly ( northwesterly) wind anomalies north ( south) of the equator. Over the NIO as the mean winds turn into southwesterly in May, the northeasterly anomalies force the second SST peak that persists through summer by reducing the wind speed and surface evaporation. Atmospheric general circulation model experiments show that the antisymmetric atmospheric pattern is a response to the TIO warming, suggestive of their mutual interaction. Thus, ocean dynamics and Rossby waves in particular are important for the warming not only locally in SWIO but also on the basin-scale north of the equator, a result with important implications for climate predictability and prediction.