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Institution

University of Hawaii at Manoa

EducationHonolulu, Hawaii, United States
About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.


Papers
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Journal ArticleDOI
TL;DR: A protective role for both TCF21 and SMC phenotypic modulation in this disease is established and these cells transform into unique fibroblast-like cells, termed ‘fibromyocytes’, rather than into a classical macrophage phenotype.
Abstract: In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of modulated SMCs in vivo during atherosclerosis and the influence of this process on coronary artery disease (CAD) risk have not been clearly established. Using single-cell RNA sequencing, we comprehensively characterized the transcriptomic phenotype of modulated SMCs in vivo in atherosclerotic lesions of both mouse and human arteries and found that these cells transform into unique fibroblast-like cells, termed 'fibromyocytes', rather than into a classical macrophage phenotype. SMC-specific knockout of TCF21-a causal CAD gene-markedly inhibited SMC phenotypic modulation in mice, leading to the presence of fewer fibromyocytes within lesions as well as within the protective fibrous cap of the lesions. Moreover, TCF21 expression was strongly associated with SMC phenotypic modulation in diseased human coronary arteries, and higher levels of TCF21 expression were associated with decreased CAD risk in human CAD-relevant tissues. These results establish a protective role for both TCF21 and SMC phenotypic modulation in this disease.

417 citations

Journal ArticleDOI
TL;DR: Data suggest that variable responsiveness to UVB radiation is evident among individuals, causing some to have low vitamin D status despite abundant sun exposure, and it seems prudent to use this value as an upper limit when prescribing vitamin D supplementation.
Abstract: Context: Lack of sun exposure is widely accepted as the primary cause of epidemic low vitamin D status worldwide. However, some individuals with seemingly adequate UV exposure have been reported to have low serum 25-hydroxyvitamin D [25(OH)D] concentration, results that might have been confounded by imprecision of the assays used. Objective: The aim was to document the 25(OH)D status of healthy individuals with habitually high sun exposure. Setting: This study was conducted in a convenience sample of adults in Honolulu, Hawaii (latitude 21°). Participants: The study population consisted of 93 adults (30 women and 63 men) with a mean (sem) age and body mass index of 24.0 yr (0.7) and 23.6 kg/m2 (0.4), respectively. Their self-reported sun exposure was 28.9 (1.5) h/wk, yielding a calculated sun exposure index of 11.1 (0.7). Main Outcome Measures: Serum 25(OH)D concentration was measured using a precise HPLC assay. Low vitamin D status was defined as a circulating 25(OH)D concentration less than 30 ng/ml. Re...

415 citations

Journal ArticleDOI
TL;DR: In this article, the global response to tropical heating is studied by performing a time integration of a 15-level primitive equation model, starting with a basic flow maintained by a constant forcing.
Abstract: The global response to tropical heating is studied by performing a time integration of a 15-level primitive equation model, starting with a basic flow maintained by a constant forcing. The direct, quasi-steady response to the tropical heating is seen during the first 20 days before baroclinic instability dominates. This technique enables the investigation of a variety of basic flows, from a resting state to a December–February 3D time-mean flow; of the timescales for establishing remote responses; and of nonlinear effects. It also allows the determination of timescales for the establishment of the response. The Gill-type response is seen in the lower troposphere in all cases. In the upper troposphere, depending on the basic conditions, the simple tropical quadrupole response of the Gill model shows considerable modification. The anticyclonic pair can be centered over the heating and can vary substantially in magnitude and vertical extent. The Rossby wave source and the upper-tropospheric divergen...

415 citations

Journal ArticleDOI
TL;DR: In this paper, two alternative hypotheses for the mechanism of dehydration of xylose to 2-furaldehyde (furfural), namely (1) a succession of reactions proceeding mainly via open-chain intermediates, and (2) an acid-catalyzed sequence proceeding through a 2,5-anhydride intermediate, are reviewed and found to favor (2).

414 citations

Journal ArticleDOI
14 Nov 2013-Nature
TL;DR: A global survey of airbursts of a kiloton or more is performed, and it is found that the number of impactors with diameters of tens of metres may be an order of magnitude higher than estimates based on other techniques, which suggests a non-equilibrium in the near-Earth asteroid population.
Abstract: The damage caused by the asteroid 17–20 metres in diameter that exploded over Chelyabinsk, Russia, on 15 February 2013 is estimated here to have an energy equivalent to about 500 kilotons of TNT. The fireball that streaked across the skies above Chelyabinsk in Russia on 15 February 2013 is providing astronomers with a wealth of information. Two papers in this issue present detailed reconstructions of the Chelyabinsk event. From an analysis of videos, Jiři Borovicka et al. determined the trajectory and velocity of the superbolide with high precision. Its orbit was similar to that of the 2-kilometre-diameter asteroid 86039 (1999 NC43), suggesting that the two bodies may be part of the same asteroid family. And they show that it broke into small pieces between the altitudes of 45 and 30 kilometres. In the companion paper, Peter Brown et al. analysed the damage caused by the airburst which they estimate was equivalent in energy to the detonation of 400 to 600 kilotons of TNT. They suggest that the number of impactors with diameters of tens of metres was an order of magnitude higher than current estimates, shifting much of the residual impact risk to these sizes. Most large (over a kilometre in diameter) near-Earth asteroids are now known, but recognition that airbursts (or fireballs resulting from nuclear-weapon-sized detonations of meteoroids in the atmosphere) have the potential to do greater damage1 than previously thought has shifted an increasing portion of the residual impact risk (the risk of impact from an unknown object) to smaller objects2. Above the threshold size of impactor at which the atmosphere absorbs sufficient energy to prevent a ground impact, most of the damage is thought to be caused by the airburst shock wave3, but owing to lack of observations this is uncertain4,5. Here we report an analysis of the damage from the airburst of an asteroid about 19 metres (17 to 20 metres) in diameter southeast of Chelyabinsk, Russia, on 15 February 2013, estimated to have an energy equivalent of approximately 500 (±100) kilotons of trinitrotoluene (TNT, where 1 kiloton of TNT = 4.185×1012 joules). We show that a widely referenced technique4,5,6 of estimating airburst damage does not reproduce the observations, and that the mathematical relations7 based on the effects of nuclear weapons—almost always used with this technique—overestimate blast damage. This suggests that earlier damage estimates5,6 near the threshold impactor size are too high. We performed a global survey of airbursts of a kiloton or more (including Chelyabinsk), and find that the number of impactors with diameters of tens of metres may be an order of magnitude higher than estimates based on other techniques8,9. This suggests a non-equilibrium (if the population were in a long-term collisional steady state the size-frequency distribution would either follow a single power law or there must be a size-dependent bias in other surveys) in the near-Earth asteroid population for objects 10 to 50 metres in diameter, and shifts more of the residual impact risk to these sizes.

414 citations


Authors

Showing all 13867 results

NameH-indexPapersCitations
Pulickel M. Ajayan1761223136241
Steven N. Blair165879132929
Qiang Zhang1611137100950
Jack M. Guralnik14845383701
Thomas J. Smith1401775113919
James A. Richardson13636375778
Donna Neuberg13581072653
Jian Zhou128300791402
Eric F. Bell12863172542
Jorge Luis Rodriguez12883473567
Bin Wang126222674364
Nicholas J. Schork12558762131
Matthew Jones125116196909
Anthony F. Jorm12479867120
Adam G. Riess118363117310
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202362
2022244
20211,111
20201,164
20191,151
20181,154