University of Hawaii at Manoa

About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.

Infertility, Fertility Drugs, and Ovarian Cancer: A Pooled Analysis of Case-Control Studies

Abstract: Controversy surrounds the relations among infertility, fertility drug use, and the risk of ovarian cancer. The authors pooled interview data on infertility and fertility drug use from eight case-control studies conducted between 1989 and 1999 in the United States, Denmark, Canada, and Australia. Odds ratios and 95% confidence intervals were calculated, adjusting for age, race, family history of ovarian cancer, duration of oral contraception use, tubal ligation, gravidity, education, and site. Included in the analysis were 5,207 cases and 7,705 controls. Among nulligravid women, attempts for more than 5 years to become pregnant compared with attempts for less than 1 year increased the risk of ovarian cancer 2.67-fold (95% confidence interval (CI): 1.91, 3.74). Among nulliparous, subfertile women, neither any fertility drug use (odds ratio (OR) = 1.60, 95% CI: 0.90, 2.87) nor more than 12 months of use (OR = 1.54, 95% CI: 0.45, 5.27) was associated with ovarian cancer. Fertility drug use in nulligravid women was associated with borderline serous tumors (OR = 2.43, 95% CI: 1.01, 5.88) but not with any invasive histologic subtypes. Endometriosis (OR = 1.73, 95% CI: 1.10, 2.71) and unknown cause of infertility (OR = 1.19, 95% CI: 1.00, 1.40) increased cancer risk. These data suggest a role for specific biologic causes of infertility, but not for fertility drugs in overall risk for ovarian cancer.

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Abstract: Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 16 x 10(-8) to P = 27 x 10(-33))

Measurements of the meson-photon transition form factors of light pseudoscalar mesons at large momentum transfer

Abstract: Using the CLEO II detector, we have measured the differential cross sections for exclusive two-photon production of light pseudoscalar mesons {pi}{sup 0}, {eta}, and {eta}{prime}. From our measurements we have obtained the form factors associated with the electromagnetic transitions {gamma}*{gamma} {yields} meson. We have measured these form factors in the momentum transfer ranges from 1.5 to 9, 20, and 30 GeV2 for {pi}{sup 0}, {eta}, and {eta}{prime}, respectively, and have made comparisons to various theoretical predictions.

Pacific–East Asian Teleconnection. Part II: How the Philippine Sea Anomalous Anticyclone is Established during El Niño Development*

Abstract: The anomalous Philippine Sea anticyclone (PSAC) conveys impacts of El Nino to east Asian climate during the mature and decay of an El Nino (from the winter to ensuing summer). It is shown that the anomalous PSAC forms in fall about one season prior to the peak El Nino; its strength increases with the El Nino intensity and its sign reverses during a La Nina. The PSAC formation concurs with abnormal deepening of the east Asian trough and with increasing number of northward recurvature of tropical storms in the western Pacific. The PSAC establishment is abrupt, coupling with a swing from a wet to dry phase of an intraseasonal oscillation (ISO) and often concurrent with early retreat of the east Asian summer monsoon. The ISO becomes inactive after PSAC establishment. The development of the PSAC is attributed to combined effects of the remote El Nino forcing, tropical- extratropical interaction, and monsoon-ocean interaction. The developing El Nino induces off-equatorial as- cending Rossby wave responses and land surface cooling in northeast Asia; both deepen the east Asian trough in fall and induces vigorous tropical-extratropical exchange of air mass and heat, which enhances the cold air outbreak and initiation of the PSAC. Through exciting descending Rossby waves, the El Nino-induced Indonesian subsidence generates low-level anticyclonic vorticity over south Asia, which is advected by mean monsoon westerly, instigating the anomalous PSAC. The ISO interacting with the underlying ocean plays a critical role in the abrupt establishment of PSAC. The wind-evaporation/entrainment feedback tends to amplify (suppress) ISO before (after) winter northeasterly monsoon commences, suggesting the roles of atmosphere-ocean inter- action and the seasonal march of background winds in changing the Philippine Sea ISO intensity and maintaining PSAC.

Finding and Comparing Syntenic Regions among Arabidopsis and the Outgroups Papaya, Poplar, and Grape: CoGe with Rosids

Abstract: In addition to the genomes of Arabidopsis (Arabidopsis thaliana) and poplar (Populus trichocarpa), two near-complete rosid genome sequences, grape (Vitis vinifera) and papaya (Carica papaya), have been recently released. The phylogenetic relationship among these four genomes and the placement of their three independent, fractionated tetraploidies sum to a powerful comparative genomic system. CoGe, a platform of multiple whole or near-complete genome sequences, provides an integrative Web-based system to find and align syntenic chromosomal regions and visualize the output in an intuitive and interactive manner. CoGe has been customized to specifically support comparisons among the rosids. Crucial facts and definitions are presented to clearly describe the sorts of biological questions that might be answered in part using CoGe, including patterns of DNA conservation, accuracy of annotation, transposability of individual genes, subfunctionalization and/or fractionation of syntenic gene sets, and conserved noncoding sequence content. This precis of an online tutorial, CoGe with Rosids (http://tinyurl.com/4a23pk), presents sample results graphically.