Institution
University of Hawaii at Manoa
Education•Honolulu, Hawaii, United States•
About: University of Hawaii at Manoa is a education organization based out in Honolulu, Hawaii, United States. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 13693 authors who have published 25161 publications receiving 1023924 citations.
Papers published on a yearly basis
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TL;DR: In this article, the authors compared the performance of the parametric stochastic efficiency decomposition (PSE) and nonparametric data envelopment analysis (DEA) approaches for a sample of swine producers in Hawaii.
367 citations
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TL;DR: Both CRACM2 andCRACM3, when overexpressed in HEK293 cells stably expressing STIM1, potentiate I( CRAC) to current amplitudes 15-20 times larger than native I(CRAC), suggesting that they can form heteromultimeric channel complexes.
367 citations
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TL;DR: The FilmArray GI Panel provides a comprehensive, rapid, and streamlined alternative to conventional methods for the etiologic diagnosis of infectious gastroenteritis in the laboratory setting, and has potential advantages including improved performance parameters, a more extensive menu of pathogens, and a turnaround time of as short as 1 h.
Abstract: The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different methodologies to test for bacterial, parasitic, and viral causes of gastroenteritis, a strategy that suffers from poor sensitivity, potentially long turnaround times, and complicated ordering practices and workflows. Additionally, there are limited or no testing methods routinely available for most diarrheagenic Escherichia coli strains, astroviruses, and sapoviruses. This study assessed the performance of the FilmArray Gastrointestinal (GI) Panel for the simultaneous detection of 22 different enteric pathogens directly from stool specimens: Campylobacter spp., Clostridium difficile (toxin A/B), Plesiomonas shigelloides, Salmonella spp., Vibrio spp., Vibrio cholerae, Yersinia enterocolitica, enteroaggregative E. coli, enteropathogenic E. coli, enterotoxigenic E. coli, Shiga-like toxin-producing E. coli (stx1 and stx2) (including specific detection of E. coli O157), Shigella spp./enteroinvasive E. coli, Cryptosporidium spp., Cyclospora cayetanensis, Entamoeba histolytica, Giardia lamblia, adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus. Prospectively collected stool specimens (n = 1,556) were evaluated using the BioFire FilmArray GI Panel and tested with conventional stool culture and molecular methods for comparison. The FilmArray GI Panel sensitivity was 100% for 12/22 targets and ≥94.5% for an additional 7/22 targets. For the remaining three targets, sensitivity could not be calculated due to the low prevalences in this study. The FilmArray GI Panel specificity was ≥97.1% for all panel targets. The FilmArray GI Panel provides a comprehensive, rapid, and streamlined alternative to conventional methods for the etiologic diagnosis of infectious gastroenteritis in the laboratory setting. The potential advantages include improved performance parameters, a more extensive menu of pathogens, and a turnaround time of as short as 1 h.
367 citations
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TL;DR: In this paper, the authors investigated the decadal change in the spring snow depth over the Tibetan Plateau and impact on the East Asian summer monsoon using station observations of snow depth data and the NCEP-NCAR reanalysis for 1962-93.
Abstract: The decadal change in the spring snow depth over the Tibetan Plateau and impact on the East Asian summer monsoon are investigated using station observations of snow depth data and the NCEP–NCAR reanalysis for 1962–93. During spring (March–April), both the domain-averaged snow depth index (SDI) and the first principal component of the empirical orthogonal function (EOF) analysis exhibit a sharp increase in snow depth after the late 1970s, which is accompanied by excessive precipitation and land surface cooling. The correlation between SDI and precipitation shows a coherent remote teleconnection from the Tibetan Plateau–northern India to western Asia. It is found that the increased snow depth over the plateau after the mid-1970s is concurrent with a deeper India–Burma trough, an intensified subtropical westerly jet as well as enhanced ascending motion over the Tibetan Plateau. Additional factors for the excessive snowfall include more moisture supply associated with the intensification of the south...
367 citations
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National Institutes of Health1, Karolinska Institutet2, University of Helsinki3, University of Cambridge4, University of Copenhagen5, Carlos III Health Institute6, Autonomous University of Madrid7, University of Tübingen8, Bosch9, German Cancer Research Center10, Ruhr University Bochum11, University of Bonn12, Hannover Medical School13, University of Eastern Finland14, Royal Brisbane and Women's Hospital15, Leiden University16, Erasmus University Rotterdam17, University of Hamburg18, University of Ulm19, Mayo Clinic20, Cancer Council Victoria21, University of Melbourne22, University of Southern California23, University of Hawaii at Manoa24, Harvard University25, Curie Institute26, Nofer Institute of Occupational Medicine27, Agency for Science, Technology and Research28, University of Sheffield29, Cancer Research UK30, International Agency for Research on Cancer31
TL;DR: The findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct.
Abstract: A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in FGFR2 was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27-1.36)) than ER-negative (1.08 (1.03-1.14)) disease (P for heterogeneity = 10(-13)). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10(-5), 10(-8), 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively). The differences in the associations between SNPs in FGFR2 and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment.
367 citations
Authors
Showing all 13867 results
Name | H-index | Papers | Citations |
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Pulickel M. Ajayan | 176 | 1223 | 136241 |
Steven N. Blair | 165 | 879 | 132929 |
Qiang Zhang | 161 | 1137 | 100950 |
Jack M. Guralnik | 148 | 453 | 83701 |
Thomas J. Smith | 140 | 1775 | 113919 |
James A. Richardson | 136 | 363 | 75778 |
Donna Neuberg | 135 | 810 | 72653 |
Jian Zhou | 128 | 3007 | 91402 |
Eric F. Bell | 128 | 631 | 72542 |
Jorge Luis Rodriguez | 128 | 834 | 73567 |
Bin Wang | 126 | 2226 | 74364 |
Nicholas J. Schork | 125 | 587 | 62131 |
Matthew Jones | 125 | 1161 | 96909 |
Anthony F. Jorm | 124 | 798 | 67120 |
Adam G. Riess | 118 | 363 | 117310 |