Institution
University of Health and Allied Sciences
Education•Ho, Ghana•
About: University of Health and Allied Sciences is a education organization based out in Ho, Ghana. It is known for research contribution in the topics: Population & Health care. The organization has 637 authors who have published 1063 publications receiving 9380 citations. The organization is also known as: UHAS & IAU-024335.
Papers
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TL;DR: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates, and there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries.
5,802 citations
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Christopher J L Murray1, Christopher J L Murray2, Christopher J L Murray3, Aleksandr Y. Aravkin2 +2269 more•Institutions (286)
TL;DR: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure.
3,059 citations
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TL;DR: To assess current trajectories towards the GPW13 UHC billion target—1 billion more people benefiting from UHC by 2023—the authors estimated additional population equivalents with UHC effective coverage from 2018 to 2023, and quantified frontiers of U HC effective coverage performance on the basis of pooled health spending per capita.
304 citations
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TL;DR: The case studies reveal the complex adaptive nature of health systems, emphasise the importance of understanding context, and highlight the role of multidisciplinary, rigorous, and adaptive processes that allow for course correction to ensure interventions have an impact.
268 citations
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University of North Carolina at Chapel Hill1, Duke University2, Liverpool School of Tropical Medicine3, University of Ouagadougou4, University of London5, Kwame Nkrumah University of Science and Technology6, Medical Research Council7, Centers for Disease Control and Prevention8, Kenya Medical Research Institute9, University of Malawi10, Karolinska Institutet11, University of Health and Allied Sciences12, University of California, San Francisco13, University of Kinshasa14, University of Massachusetts Amherst15
TL;DR: An assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies is developed and validated by evaluating mixtures of laboratory parasite strains, and used to screen P. falciparum parasites from >1100 African infections collected since 2002.
Abstract: Plasmodium falciparum parasites that are resistant to artemisinins have been detected in Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13-propeller gene. The molecular epidemiology of these artemisinin resistance genotypes in African parasite populations is unknown. We developed an assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies, validated it by evaluating mixtures of laboratory parasite strains, and then used it to screen P. falciparum parasites from >1100 African infections collected since 2002 from 14 sites across sub-Saharan Africa. We found no mutations in African parasite populations that are associated with artemisinin resistance in Southeast Asian parasites. However, we observed 15 coding mutations, including 12 novel mutations, and limited allele sharing between parasite populations, consistent with a large reservoir of naturally occurring K13-propeller variation. Although polymorphisms associated with artemisinin resistance in P. falciparum in Southeast Asia are not prevalent in sub-Saharan Africa, numerous K13-propeller coding polymorphisms circulate in Africa. Although their distributions do not support a widespread selective sweep for an artemisinin-resistant phenotype, the impact of these mutations on artemisinin susceptibility is unknown and will require further characterization. Rapid, scalable molecular surveillance offers a useful adjunct in tracking and containing artemisinin resistance.
253 citations
Authors
Showing all 642 results
Name | H-index | Papers | Citations |
---|---|---|---|
Christopher J L Murray | 209 | 754 | 310329 |
Fred Binka | 55 | 178 | 9536 |
Seth Owusu-Agyei | 52 | 276 | 10805 |
John O. Gyapong | 50 | 145 | 7813 |
Sake J. de Vlas | 50 | 226 | 8740 |
Wim Groot | 47 | 377 | 8993 |
Abraham Hodgson | 46 | 131 | 6871 |
Milena Pavlova | 40 | 246 | 5372 |
Mehdi Ahmadi | 39 | 144 | 11433 |
Irene Akua Agyepong | 36 | 115 | 5006 |
Margaret Gyapong | 35 | 115 | 3307 |
Abraham Oduro | 35 | 155 | 3539 |
Said Aboud | 35 | 184 | 3819 |
David Guwatudde | 28 | 96 | 2789 |
Billy Ngasala | 27 | 68 | 2552 |