Institution
University of Houston
Education•Houston, Texas, United States•
About: University of Houston is a education organization based out in Houston, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 23074 authors who have published 53903 publications receiving 1641968 citations.
Topics: Population, Poison control, Anxiety, Finite element method, Catalysis
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The results provide an interesting mechanism whereby modifying ANGPTL4, a central player in fat storage regulation, through manipulating gut flora could be an important gateway upon which intervention trials of weight management can be based.
Abstract: Background
Intervention strategies for obesity are global issues that require immediate attention. One approach is to exploit the growing consensus that beneficial gut microbiota could be of use in intervention regimes. Our objective was to determine the mechanism by which the probiotic bacteria Lactobacillus paracasei ssp paracasei F19 (F19) could alter fat storage. Angiopoietin-like 4 (ANGPTL4) is a circulating lipoprotein lipase (LPL) inhibitor that controls triglyceride deposition into adipocytes and has been reported to be regulated by gut microbes.
Methodology/Principal Findings
A diet intervention study of mice fed high-fat chow supplemented with F19 was carried out to study potential mechanistic effects on fat storage. Mice given F19 displayed significantly less body fat, as assessed by magnetic resonance imaging, and a changed lipoprotein profile. Given that previous studies on fat storage have identified ANGPTL4 as an effector, we also investigated circulating levels of ANGPTL4, which proved to be higher in the F19-treated group. This increase, together with total body fat and triglyceride levels told a story of inhibited LPL action through ANGPTL4 leading to decreased fat storage. Co-culture experiments of colonic cell lines and F19 were set up in order to monitor any ensuing alterations in ANGPTL4 expression by qPCR. We observed that potentially secreted factors from F19 can induce ANGPTL4 gene expression, acting in part through the peroxisome proliferator activated receptors alpha and gamma. To prove validity of in vitro findings, germ-free mice were monocolonized with F19. Here we again found changes in serum triglycerides as well as ANGPTL4 in response to F19.
Conclusions/Significance
Our results provide an interesting mechanism whereby modifying ANGPTL4, a central player in fat storage regulation, through manipulating gut flora could be an important gateway upon which intervention trials of weight management can be based.
280 citations
••
TL;DR: The current review examines the existing literature around three major themes: the definition ofxiety in dementia, the properties of available instruments for assessment, and the clinical characteristics of anxiety in this population.
280 citations
••
TL;DR: In this paper, the authors use intraday data to compute weekly realized moments for equity returns and study their time-series and cross-sectional properties, finding a strong relation between realized volatility and next week's stock returns.
280 citations
•
TL;DR: In this article, the authors provide practical advice for applied economists regarding specification and interpretation of linear regression models with interaction terms, and provide advice for applying economists regarding how to interpret such models.
Abstract: We provide practical advice for applied economists regarding specification and interpretation of linear regression models with interaction terms.
279 citations
••
TL;DR: The first measurement of the charged particle multiplicity density at midrapidity in Pb-Pb collisions at a center-of-mass energy per nucleon pair root s(NN) = 2.76 TeV is presented in this paper.
Abstract: The first measurement of the charged-particle multiplicity density at midrapidity in Pb-Pb collisions at a center-of-mass energy per nucleon pair root s(NN) = 2.76 TeV is presented. For an event sample corresponding to the most central 5% of the hadronic cross section, the pseudorapidity density of primary charged particles at midrapidity is 1584 +/- 4(stat) +/- 76(syst), which corresponds to 8.3 +/- 0.4(syst) per participating nucleon pair. This represents an increase of about a factor 1.9 relative to pp collisions at similar collision energies, and about a factor 2.2 to central Au-Au collisions at root s(NN) = 0.2 TeV. This measurement provides the first experimental constraint for models of nucleus-nucleus collisions at LHC energies.
279 citations
Authors
Showing all 23345 results
Name | H-index | Papers | Citations |
---|---|---|---|
Matthew Meyerson | 194 | 553 | 243726 |
Gad Getz | 189 | 520 | 247560 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Pulickel M. Ajayan | 176 | 1223 | 136241 |
Zhenan Bao | 169 | 865 | 106571 |
Marc Weber | 167 | 2716 | 153502 |
Steven N. Blair | 165 | 879 | 132929 |
Martin Karplus | 163 | 831 | 138492 |
Dongyuan Zhao | 160 | 872 | 106451 |
Xiang Zhang | 154 | 1733 | 117576 |
Jan-Åke Gustafsson | 147 | 1058 | 98804 |
James M. Tour | 143 | 859 | 91364 |
Guanrong Chen | 141 | 1652 | 92218 |
Naomi J. Halas | 140 | 435 | 82040 |
Antonios G. Mikos | 138 | 694 | 70204 |