University of Iceland

About: University of Iceland is a education organization based out in Reykjavik, Suðurnes, Iceland. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 5423 authors who have published 16199 publications receiving 694762 citations. The organization is also known as: Háskóli Íslands.

The European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2016: a summary.

Abstract: Background This article summarizes the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry's 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2015 within 36 countries. Methods In 2016 and 2017, the ERA-EDTA Registry received data on patients who were undergoing RRT for ESRD in 2015, from 52 national or regional renal registries. Thirty-two registries provided individual patient-level data and 20 provided aggregated-level data. The incidence, prevalence and survival probabilities of these patients were determined. Results In 2015, 81 373 individuals commenced RRT for ESRD, equating to an overall unadjusted incidence rate of 119 per million population (pmp). The incidence ranged by 10-fold, from 24 pmp in Ukraine to 232 pmp in the Czech Republic. Of the patients commencing RRT, almost two-thirds were men, over half were aged ≥65 years and a quarter had diabetes mellitus as their primary renal diagnosis. Treatment modality at the start of RRT was haemodialysis for 85% of the patients, peritoneal dialysis for 11% and a kidney transplant for 4%. By Day 91 of commencing RRT, 82% of patients were receiving haemodialysis, 13% peritoneal dialysis and 5% had a kidney transplant. On 31 December 2015, 546 783 individuals were receiving RRT for ESRD, corresponding to an unadjusted prevalence of 801 pmp. This ranged throughout Europe by more than 10-fold, from 178 pmp in Ukraine to 1824 pmp in Portugal. In 2015, 21 056 kidney transplantations were performed, equating to an overall unadjusted transplant rate of 31 pmp. This varied from 2 pmp in Ukraine to 94 pmp in the Spanish region of Cantabria. For patients commencing RRT during 2006-10, the 5-year unadjusted patient survival probabilities on all RRT modalities combined was 50.0% (95% confidence interval 49.9-50.1).

Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

Abstract: Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with an increased risk for autism. Furthermore, several studies suggest a role of environmental factors in autism spectrum disorders (ASD). First, arguments for a genetic contribution to autism, based on updated family and twin studies, are examined. Second, a review of possible prenatal, perinatal and postnatal environmental risk factors for ASD are presented. Then, the hypotheses are discussed concerning the underlying mechanisms related to a role of environmental factors in the development of ASD in association with genetic factors. In particular, epigenetics as a candidate biological mechanism for gene X environment interactions is considered and the possible role of epigenetic mechanisms reported in genetic disorders associated with ASD is discussed. Furthermore, the example of in utero exposure to valproate provides a good illustration of epigenetic mechanisms involved in ASD and innovative therapeutic strategies. Epigenetic remodeling by environmental factors opens new perspectives for a better understanding, prevention and early therapeutic intervention of ASD.

A New Pansharpening Algorithm Based on Total Variation

Abstract: In this letter, we present a new method for the pansharpening of multispectral satellite imagery. Pansharpening is the process of synthesizing a high spatial resolution multispectral image from a low spatial resolution multispectral image and a high-resolution panchromatic (PAN) image. The method uses total variation to regularize an ill-posed problem dictated by a widely used explicit image formation model. This model is based on the assumptions that a linear combination of the bands of the pansharpened image gives the PAN image and that a decimation of the pansharpened image gives the original multispectral image. Experimental results are based on two real datasets and the quantitative quality of the pansharpened images is evaluated using a number of spatial and spectral metrics, some of which have been recently proposed and do not need a reference image. The proposed method compares favorably to other well-known methods for pansharpening and produces images of excellent spatial and spectral quality.

Exploiting spectral and spatial information in hyperspectral urban data with high resolution

Abstract: Very high resolution hyperspectral data should be very useful to provide detailed maps of urban land cover. In order to provide such maps, both accurate and precise classification tools need, however, to be developed. In this letter, new methods for classification of hyperspectral remote sensing data are investigated, with the primary focus on multiple classifications and spatial analysis to improve mapping accuracy in urban areas. In particular, we compare spatial reclassification and mathematical morphology approaches. We show results for classification of DAIS data over the town of Pavia, in northern Italy. Classification maps of two test areas are given, and the overall and individual class accuracies are analyzed with respect to the parameters of the proposed classification procedures.

Nordic Cancer Registries – an overview of their procedures and data comparability

Abstract: Background: The Nordic Cancer Registries are among the oldest population-based registries in the world, with more than 60 years of complete coverage of what is now a combined population of 26 milli...