University of Iceland

About: University of Iceland is a education organization based out in Reykjavik, Suðurnes, Iceland. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 5423 authors who have published 16199 publications receiving 694762 citations. The organization is also known as: Háskóli Íslands.

Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document

Abstract: Introduction Fabry disease (FD) is a lysosomal storage disorder resulting in progressive nervous system, kidney and heart disease. Enzyme replacement therapy (ERT) may halt or attenuate disease progression. Since administration is burdensome and expensive, appropriate use is mandatory. We aimed to define European consensus recommendations for the initiation and cessation of ERT in patients with FD.

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

Abstract: Persistent insomnia is among the most frequent complaints in general practice. To identify genetic factors for insomnia complaints, we performed a genome-wide association study (GWAS) and a genome-wide gene-based association study (GWGAS) in 113,006 individuals. We identify three loci and seven genes associated with insomnia complaints, with the associations for one locus and five genes supported by joint analysis with an independent sample (n = 7,565). Our top association (MEIS1, P < 5 × 10-8) has previously been implicated in restless legs syndrome (RLS). Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. Sex-specific analyses suggest that there are different genetic architectures between the sexes in addition to shared genetic factors. We show substantial positive genetic correlation of insomnia complaints with internalizing personality traits and metabolic traits and negative correlation with subjective well-being and educational attainment. These findings provide new insight into the genetic architecture of insomnia.

Relationships between structure and function in streams contrasting in temperature

Abstract: Summary 1. We studied 10 first-order Icelandic streams differing in geothermal influence in separate catchments. Summer temperature (August–September) ranged between 6 and 23 °C. 2. Macroinvertebrate evenness and species overlap decreased significantly with temperature whereas taxon richness showed no response. In total, 35 macroinvertebrate species were found with Chironomidae the dominant taxonomic group. Macroinvertebrate density increased significantly with temperature. Dominant species in the warm streams were Lymnaea peregra and Simulium vittatum. Algal biomass, macrophyte cover and richness were unrelated to temperature. Densities of trout (Salmo trutta), the only fish species present, reflected habitat conditions and to a lesser degree temperature. 3. Density of filter-feeders increased significantly with temperature whereas scraper density, the other dominant functional feeding group, was unrelated to temperature. Stable isotope analysis revealed a positive relationship between δ15N and temperature across several trophic levels. No pattern was found with regard to δ13C and temperature. 4. Leaf litter decomposition in both fine and coarse mesh leaf bags were significantly correlated to temperature. In coarse mesh leaf packs breakdown rates were almost doubled compared with fine mesh, ranging between 0.5 and 1.3 g DW 28 days−1. Nutrient diffusion substrates showed that the streams were primarily nitrogen limited across the temperature gradient while a significant additional effect of phosphorous was found with increasing temperature. 5. Structural and functional attributes gave complementary information which all indicated a change with temperature similar to what is found in moderately polluted streams. Our results therefore suggest that lotic ecosystems could be degraded by global warming.

Greed is good : approximating independent sets in sparse and bounded-degree graphs

Abstract: Theminimum-degree greedy algorithm, or Greedy for short, is a simple and well-studied method for finding independent sets in graphs. We show that it achieves a performance ratio of (Δ+2)/3 for approximating independent sets in graphs with degree bounded by Δ. The analysis yields a precise characterization of the size of the independent sets found by the algorithm as a function of the independence number, as well as a generalization of Turan's bound. We also analyze the algorithm when run in combination with a known preprocessing technique, and obtain an improved $$(2\bar d + 3)/5$$ performance ratio on graphs with average degree $$\bar d$$ , improving on the previous best $$(\bar d + 1)/2$$ of Hochbaum. Finally, we present an efficient parallel and distributed algorithm attaining the performance guarantees of Greedy.