Institution
University of Iceland
Education•Reykjavik, Suðurnes, Iceland•
About: University of Iceland is a education organization based out in Reykjavik, Suðurnes, Iceland. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 5423 authors who have published 16199 publications receiving 694762 citations. The organization is also known as: Háskóli Íslands.
Papers published on a yearly basis
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TL;DR: A method to address the problem of mixed pixels and to obtain a finer spatial resolution of the land cover classification maps is proposed, which exploits the advantages of both soft classification techniques and spectral unmixing algorithms, in order to determine the fractional abundances of the classes at a sub-pixel scale.
Abstract: The problem of classification of hyperspectral images containing mixed pixels is addressed. Hyperspectral imaging is a continuously growing area of remote sensing applications. The wide spectral range of such imagery, providing a very high spectral resolution, allows to detect and classify surfaces and chemical elements of the observed image. The main problem of hyperspectral data is the (relatively) low spatial resolution, which can vary from a few to tens of meters. Many factors make the spatial resolution one of the most expensive and hardest to improve in imaging systems. For classification, the major problem caused by low spatial resolution are the mixed pixels, i.e., parts of the image where more than one land cover map lie in the same pixel. In this paper, we propose a method to address the problem of mixed pixels and to obtain a finer spatial resolution of the land cover classification maps. The method exploits the advantages of both soft classification techniques and spectral unmixing algorithms, in order to determine the fractional abundances of the classes at a sub-pixel scale. Spatial regularization by simulated annealing is finally performed to spatially locate the obtained classes. Experiments carried out on synthetic real data sets show excellent results both from a qualitative and quantitative point of view.
164 citations
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TL;DR: In this article, a positive linear relation between maximum throw and length of the Holocene faults was found, which can be explained by a similar relation between fault length and width, where the width (depth) must be the smallest (controlling) dimension of many faults.
Abstract: The divergent plate boundary in Iceland is characterized by 40–80 km long and 5–10 km wide swarms of tension fractures (∼102 m long) and normal faults (∼103 m long). The upper part of the crust is mainly composed of lava flows, with abundant columnar joints that are mostly perpendicular to the lava contacts. The lava flows are horizontal at the surface of the rift zone but become tilted at the rate of 1° for every 150 m depth in the crust. At the surface of the rift zone the joints are vertical and parallel to the vertical principal stress. Because of tilting of the lava pile, the columnar joints become oblique to this stress, hence becoming potential shear fractures, and form echelon sets at greater depths in the crust. Theoretical considerations suggest that normal faults start to nucleate on sets of en echelon columnar joints and/or large-scale tension fractures at crustal depths of 0.5–1.5 km. The width (depth) must be the smallest (controlling) dimension of many faults. Nevertheless, there is a positive linear relation (r = 0.91) between maximum throw and length of the Holocene faults. If the faults grow as self-similar structures, the throw-length relationship can be explained by a similar relation between fault length and width.
164 citations
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TL;DR: A novel mechanism by which Wnt signaling and β-catenin activate gene expression is revealed, with significant implications for the understanding of both melanocyte development and melanoma.
Abstract: Commitment to the melanocyte lineage is characterized by the onset of expression of the microphthalmia-associated transcription factor (Mitf). This transcription factor plays a fundamental role in melanocyte development and maintenance and seems to be crucial for the survival of malignant melanocytes. Furthermore, Mitf has been shown to be involved in cell cycle regulation and to play important functions in self-renewal and maintenance of melanocyte stem cells. Although little is known about how Mitf regulates these various processes, one possibility is that Mitf interacts with other regulators. Here we show that Mitf can interact directly with beta-catenin, the key mediator of the canonical Wnt signaling pathway. The Wnt signaling pathway plays a critical role in melanocyte development and is intimately involved in triggering melanocyte stem cell proliferation. Significantly, constitutive activation of this pathway is a feature of a number of cancers including malignant melanoma. Here we show that Mitf can redirect beta-catenin transcriptional activity away from canonical Wnt signaling-regulated genes toward Mitf-specific target promoters to activate transcription. Thus, by a feedback mechanism, Mitf can diversify the output of canonical Wnt signaling to enhance the repertoire of genes regulated by beta-catenin. Our results reveal a novel mechanism by which Wnt signaling and beta-catenin activate gene expression, with significant implications for our understanding of both melanocyte development and melanoma.
164 citations
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TL;DR: On the effect of the electron energy distribution on the plasma parameters of argon discharge, a global (volume averaged) model study is presented in this article, where the model is extended to a global setting.
Abstract: On the effect of the electron energy distribution on the plasma parameters of argon discharge : A global (volume averaged) model study
164 citations
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TL;DR: Convincing and probable evidence was found for benefits of breastfeeding on several outcomes and the recommendation in NNR2004 about exclusive breastfeeding for 6 months and continued partial breastfeeding thereafter can stand unchanged.
Abstract: The present systematic literature review is part of the 5th revision of the Nordic Nutrition Recommendations. The overall aim was to review recent scientific data valid in a Nordic setting on the short- and long-term health effects of breastfeeding (duration of both any and exclusive breastfeeding) and introduction of foods other than breast milk. The initial literature search resulted in 2,011 abstracts; 416 identified as potentially relevant. Full paper review resulted in 60 quality assessed papers (6A, 48B, and 6C). A complementary search found some additional papers. The grade of evidence was classified as convincing, probable, limited-suggestive, and limited-no conclusion. The evidence was convincing of a protective dose/duration effect of breastfeeding against overweight and obesity in childhood and adolescence, overall infections, acute otitis media, and gastrointestinal and respiratory tract infections. The evidence was probable that exclusive breastfeeding for longer than 4 months is associated with slower weight gain during the second half of the first year which could be part of the reason behind the reduced risk of later overweight or obesity. There was also probable evidence that breastfeeding is a protective factor against inflammatory bowel disease, celiac disease, and diabetes (type 1 and 2), provides beneficial effects on IQ and developmental scores of children as well as a small reductive effect on blood pressure and blood cholesterol levels in adulthood. Other associations explored were limited-suggestive or inconclusive. In conclusion, convincing and probable evidence was found for benefits of breastfeeding on several outcomes. The recommendation in NNR2004 about exclusive breastfeeding for 6 months and continued partial breastfeeding thereafter can stand unchanged. The relatively low proportion of infants in the Nordic countries following this recommendation indicates that strategies that protect, support and promote breastfeeding should be enhanced, and should also recognize the benefits for long-term health.
164 citations
Authors
Showing all 5561 results
Name | H-index | Papers | Citations |
---|---|---|---|
Albert Hofman | 267 | 2530 | 321405 |
Kari Stefansson | 206 | 794 | 174819 |
Ronald Klein | 194 | 1305 | 149140 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Unnur Thorsteinsdottir | 167 | 444 | 121009 |
Vilmundur Gudnason | 159 | 837 | 123802 |
Hakon Hakonarson | 152 | 968 | 101604 |
Bernhard O. Palsson | 147 | 831 | 85051 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Fernando Rivadeneira | 146 | 628 | 86582 |
Rattan Lal | 140 | 1383 | 87691 |
Jonathan G. Seidman | 137 | 563 | 89782 |
Christine E. Seidman | 134 | 519 | 67895 |
Augustine Kong | 134 | 237 | 89818 |
Timothy M. Frayling | 133 | 500 | 100344 |