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Institution

University of Iceland

EducationReykjavik, Suðurnes, Iceland
About: University of Iceland is a education organization based out in Reykjavik, Suðurnes, Iceland. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 5423 authors who have published 16199 publications receiving 694762 citations. The organization is also known as: Háskóli Íslands.


Papers
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Journal ArticleDOI
TL;DR: The Letter shows the potential of polariton lattices for emulating flat band Hamiltonians with spin-orbit coupling, orbital degrees of freedom, and interactions.
Abstract: We study exciton polaritons in a two-dimensional Lieb lattice of micropillars. The energy spectrum of the system features two flat bands formed from S and P_{x,y} photonic orbitals, into which we trigger bosonic condensation under high power excitation. The symmetry of the orbital wave functions combined with photonic spin-orbit coupling gives rise to emission patterns with pseudospin texture in the flat band condensates. Our Letter shows the potential of polariton lattices for emulating flat band Hamiltonians with spin-orbit coupling, orbital degrees of freedom, and interactions.

160 citations

Journal ArticleDOI
TL;DR: An integrated, iterative approach of computational modeling, in vitro experiments, metabolomics, and genomic analysis is presented to accelerate the identification of metabolic capabilities for poorly characterized (anaerobic) microorganisms to yield novel biochemical insights about the target organism.
Abstract: The human gut microbiota plays a central role in human well-being and disease. In this study, we present an integrated, iterative approach of computational modeling, in vitro experiments, metabolomics, and genomic analysis to accelerate the identification of metabolic capabilities for poorly characterized (anaerobic) microorganisms. We demonstrate this approach for the beneficial human gut microbe Faecalibacterium prausnitzii strain A2-165. We generated an automated draft reconstruction, which we curated against the limited biochemical data. This reconstruction modeling was used to develop in silico and in vitro a chemically defined medium (CDM), which was validated experimentally. Subsequent metabolomic analysis of the spent medium for growth on CDM was performed. We refined our metabolic reconstruction according to in vitro observed metabolite consumption and secretion and propose improvements to the current genome annotation of F. prausnitzii A2-165. We then used the reconstruction to systematically characterize its metabolic properties. Novel carbon source utilization capabilities and inabilities were predicted based on metabolic modeling and validated experimentally. This study resulted in a functional metabolic map of F. prausnitzii, which is available for further applications. The presented workflow can be readily extended to other poorly characterized and uncharacterized organisms to yield novel biochemical insights about the target organism.

160 citations

Journal ArticleDOI
TL;DR: In this paper, the authors define the complete postglacial eruptive history of the 170km-long Western Volcanic Zone (WVZ) of Iceland, the ultraslow-spreading western boundary of the south Iceland microplate.
Abstract: New field observations, age constraints, and extensive chemical analyses define the complete postglacial eruptive history of the 170-km-long Western Volcanic Zone (WVZ) of Iceland, the ultraslow-spreading western boundary of the south Iceland microplate. We have identified 44 separate eruptive units, 10 of which are small-volume eruptions associated with the flanking Grimsnes system. Overall chemical variations are consistent with very simplified models of melting of a source approximating primitive mantle composition. The 17 eruptions in the first 3000 years of postglacial time account for about 64% of the total postglacial production and are incompatible-element depleted compared to younger units, consistent with enhanced melting as a consequence of rebound immediately following deglaciation. Steadily declining eruption rates for the last 9000 years also correlate with changes in average incompatible element ratios that appear to reflect continued decline in melting extents to the present day. This result is not restricted to the WVZ, however, and may herald a decline in melting throughout all of western Iceland during later postglacial time. Lavas from the northern part of the WVZ are depleted in incompatible elements relative to those farther south at all times, indicating either a long-wavelength gradient in mantle source composition or variations in the melting process along axis. We find no evidence in the postglacial volcanic record for current failure of the WVZ, despite evidence for continued propagation of the eastern margin of the microplate. The dominance of lava shields in the eruptive history of the WVZ contrasts with the higher number of fissure eruptions in other Icelandic volcanic zones. WVZ shields represent long-duration, low-effusion rate eruptions fed by recharge magma arising out of the mantle. Average effusion rate is the key variable distinguishing shield and fissure eruptions, both within the WVZ and between different volcanic zones. High effusion rate, large-volume eruptions require the presence of large crustal magma reservoirs, which have been rare or absent in the WVZ throughout postglacial time.

159 citations

Journal ArticleDOI
Karin Hek1, Ayse Demirkan1, Jari Lahti2, Jari Lahti3, Antonio Terracciano4, Alexander Teumer5, Marilyn C. Cornelis6, Najaf Amin1, Erin Bakshis7, Jens Baumert, Jingzhong Ding8, Yongmei Liu8, Kristin D. Marciante9, Osorio Meirelles4, Mike A. Nalls4, Yan V. Sun10, Nicole Vogelzangs11, Lei Yu12, Stefania Bandinelli, Emelia J. Benjamin13, David A. Bennett12, Dorret I. Boomsma11, Alessandra Cannas, Laura H. Coker8, Eco J. C. de Geus11, Philip L. De Jager6, Ana V. Diez-Roux7, Shaun Purcell6, Frank B. Hu6, Eric B. Rimm6, David J. Hunter6, Majken K. Jensen6, Gary C. Curhan6, Kenneth Rice9, Alan D. Penman14, Jerome I. Rotter15, Nona Sotoodehnia9, Rebecca T. Emeny, Johan G. Eriksson, Denis A. Evans12, Luigi Ferrucci4, Myriam Fornage16, Vilmundur Gudnason17, Albert Hofman1, Thomas Illig18, Sharon L.R. Kardia7, Margaret Kelly-Hayes13, Karestan C. Koenen19, Peter Kraft6, Maris Kuningas1, Joseph M. Massaro13, David Melzer20, Antonella Mulas, Cornelis L. Mulder1, Anna Murray20, Ben A. Oostra1, Aarno Palotie, Brenda W.J.H. Penninx, Astrid Petersmann5, Luke C. Pilling20, Bruce M. Psaty21, Rajesh Rawal, Eric M. Reiman22, Andrea Schulz5, Joshua M. Shulman23, Andrew B. Singleton4, Albert V. Smith17, Angelina R. Sutin3, Angelina R. Sutin4, André G. Uitterlinden1, Henry Völzke5, Elisabeth Widen2, Kristine Yaffe24, Alan B. Zonderman4, Francesco Cucca, Tamara B. Harris4, Karl-Heinz Ladwig, David J. Llewellyn20, Katri Räikkönen2, Toshiko Tanaka4, Cornelia M. van Duijn1, Hans J. Grabe5, Lenore J. Launer4, Kathryn L. Lunetta13, Thomas H. Mosley14, Anne B. Newman25, Henning Tiemeier1, Joanne M. Murabito13 
TL;DR: The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms, as well as a combined meta-analysis of all 22 discovery and replication studies.

159 citations


Authors

Showing all 5561 results

NameH-indexPapersCitations
Albert Hofman2672530321405
Kari Stefansson206794174819
Ronald Klein1941305149140
Eric Boerwinkle1831321170971
Unnur Thorsteinsdottir167444121009
Vilmundur Gudnason159837123802
Hakon Hakonarson152968101604
Bernhard O. Palsson14783185051
Andrew T. Hattersley146768106949
Fernando Rivadeneira14662886582
Rattan Lal140138387691
Jonathan G. Seidman13756389782
Christine E. Seidman13451967895
Augustine Kong13423789818
Timothy M. Frayling133500100344
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202377
2022209
20211,222
20201,118
20191,140
20181,070