Institution
University of Iceland
Education•Reykjavik, Suðurnes, Iceland•
About: University of Iceland is a education organization based out in Reykjavik, Suðurnes, Iceland. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 5423 authors who have published 16199 publications receiving 694762 citations. The organization is also known as: Háskóli Íslands.
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TL;DR: In this article, the authors investigate alternative methods to relate the SDGs to overall measures of sustainable wellbeing that can motivate and guide the process of global societal change, and propose a sustainable wellbeing index (SWI) that connects with and complements the SDG dashboard.
443 citations
TL;DR: It appears that cyclodextrins can only enhance topical drug delivery in the presence of water.
442 citations
St George's, University of London1, University of Oxford2, University of Newcastle3, University of Edinburgh4, University of Maryland, Baltimore5, University of Texas Health Science Center at Houston6, Erasmus University Rotterdam7, Ludwig Maximilian University of Munich8, University of Iceland9, deCODE genetics10, National Institutes of Health11, University of Washington12, Imperial College London13, Boston University14, University of Virginia15, Fred Hutchinson Cancer Research Center16, Utrecht University17, Autonomous University of Barcelona18, Medical University of Graz19, University of Glasgow20, University of Münster21, National University of Ireland, Galway22, University of Cambridge23, Jagiellonian University24, Katholieke Universiteit Leuven25, Lund University26, University of Copenhagen27, University of Kiel28, University of Dundee29, Instituto Nacional de Saúde Dr. Ricardo Jorge30, Instituto de Medicina Molecular31, University Medical Center Utrecht32, Brigham and Women's Hospital33, Broad Institute34, Karolinska Institutet35, University of Pennsylvania36, McMaster University37, University of Mississippi38, Harvard University39, Group Health Research Institute40, University of Mississippi Medical Center41, Mayo Clinic42
TL;DR: The results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations validated are specific to a stroke subtype, and this finding has two implications.
Abstract: Summary Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.
440 citations
TL;DR: In this article, the authors describe the development of the Galactic Interstellar Emission Model (GIEM) which is the standard adopted by the LAT Collaboration and is publicly available, based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse-Compton emission produced in the Galaxy.
Abstract: Most of the celestial γ rays detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope originate from the interstellar medium when energetic cosmic rays interact with interstellar nucleons and photons. Conventional point-source and extended-source studies rely on the modeling of this diffuse emission for accurate characterization. Here, we describe the development of the Galactic Interstellar Emission Model (GIEM), which is the standard adopted by the LAT Collaboration and is publicly available. This model is based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse-Compton emission produced in the Galaxy. In the GIEM, we also include large-scale structures like Loop I and the Fermi bubbles. The measured gas emissivity spectra confirm that the cosmic-ray proton density decreases with Galactocentric distance beyond 5 kpc from the Galactic Center. The measurements also suggest a softening of the proton spectrum with Galactocentric distance. We observe that the Fermi bubbles have boundaries with a shape similar to a catenary at latitudes below 20° and we observe an enhanced emission toward their base extending in the north and south Galactic directions and located within ∼4° of the Galactic Center.
438 citations
Harvard University1, National Institutes of Health2, Boston University3, University of Washington4, Technische Universität München5, University of Minnesota6, Cleveland Clinic7, Ludwig Maximilian University of Munich8, Massachusetts Institute of Technology9, University of Mississippi10, Vanderbilt University11, United States Department of Veterans Affairs12, Wake Forest University13, Erasmus University Rotterdam14, University of Geneva15, Johns Hopkins University16, Cedars-Sinai Medical Center17, University of Iceland18, University of Tartu19, Estonian Biocentre20, University of Duisburg-Essen21, University of Bonn22, University of Texas Health Science Center at Houston23, Scripps Research Institute24, Group Health Cooperative25
TL;DR: A meta-analysis of genome-wide association studies conducted using 1,335 individuals with lone AF and 12,844 unaffected individuals found an association on chromosome 1q21 to lone AF, which is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization.
Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF. This condition affects a subset of individuals without overt heart disease and with an increased heritability of AF. We report a meta-analysis of genome-wide association studies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (referents). Cases were obtained from the German AF Network, Heart and Vascular Health Study, the Atherosclerosis Risk in Communities Study, the Cleveland Clinic and Massachusetts General Hospital. We identified an association on chromosome 1q21 to lone AF (rs13376333, adjusted odds ratio = 1.56; P = 6.3 x 10(-12)), and we replicated this association in two independent cohorts with lone AF (overall combined odds ratio = 1.52, 95% CI 1.40-1.64; P = 1.83 x 10(-21)). rs13376333 is intronic to KCNN3, which encodes a potassium channel protein involved in atrial repolarization.
437 citations
Authors
Showing all 5561 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Albert Hofman | 267 | 2530 | 321405 |
| Kari Stefansson | 206 | 794 | 174819 |
| Ronald Klein | 194 | 1305 | 149140 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Unnur Thorsteinsdottir | 167 | 444 | 121009 |
| Vilmundur Gudnason | 159 | 837 | 123802 |
| Hakon Hakonarson | 152 | 968 | 101604 |
| Bernhard O. Palsson | 147 | 831 | 85051 |
| Andrew T. Hattersley | 146 | 768 | 106949 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Rattan Lal | 140 | 1383 | 87691 |
| Jonathan G. Seidman | 137 | 563 | 89782 |
| Christine E. Seidman | 134 | 519 | 67895 |
| Augustine Kong | 134 | 237 | 89818 |
| Timothy M. Frayling | 133 | 500 | 100344 |