Institution
University of Iceland
Education•Reykjavik, Suðurnes, Iceland•
About: University of Iceland is a education organization based out in Reykjavik, Suðurnes, Iceland. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 5423 authors who have published 16199 publications receiving 694762 citations. The organization is also known as: Háskóli Íslands.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the Fermi Large Area Telescope (LAT) was used to detect a source positionally coincident with the young supernova remnant (SNR) RX J1713.7-3946.
Abstract: We present observations of the young Supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0.55$^{\circ} \pm 0.04^{\circ}$ matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allows us to identify the LAT source with the supernova remnant RX J1713.7-3946. The spectrum of the source can be described by a very hard power-law with a photon index of $\Gamma = 1.5 \pm 0.1$ that coincides in normalization with the steeper H.E.S.S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.
302 citations
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TL;DR: A previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin is discovered through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders.
Abstract: Through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin. A missense variant in this gene, c.2161C>T, results in the conceptual amino acid substitution p.Arg721Trp, has an allelic frequency of 0.38% in Icelanders and associates with sick sinus syndrome with an odds ratio = 12.53 and P = 1.5 × 10⁻²⁹. We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant.
302 citations
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TL;DR: This survey paper presents a systematic review of deep learning-based HSI classification literatures and compares several strategies to improve classification performance, which can provide some guidelines for future studies on this topic.
Abstract: Hyperspectral image (HSI) classification has become a hot topic in the field of remote sensing. In general, the complex characteristics of hyperspectral data make the accurate classification of such data challenging for traditional machine learning methods. In addition, hyperspectral imaging often deals with an inherently nonlinear relation between the captured spectral information and the corresponding materials. In recent years, deep learning has been recognized as a powerful feature-extraction tool to effectively address nonlinear problems and widely used in a number of image processing tasks. Motivated by those successful applications, deep learning has also been introduced to classify HSIs and demonstrated good performance. This survey paper presents a systematic review of deep learning-based HSI classification literatures and compares several strategies for this topic. Specifically, we first summarize the main challenges of HSI classification which cannot be effectively overcome by traditional machine learning methods, and also introduce the advantages of deep learning to handle these problems. Then, we build a framework that divides the corresponding works into spectral-feature networks, spatial-feature networks, and spectral–spatial-feature networks to systematically review the recent achievements in deep learning-based HSI classification. In addition, considering the fact that available training samples in the remote sensing field are usually very limited and training deep networks require a large number of samples, we include some strategies to improve classification performance, which can provide some guidelines for future studies on this topic. Finally, several representative deep learning-based classification methods are conducted on real HSIs in our experiments.
301 citations
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Medical Research Council1, Erasmus University Rotterdam2, University of Eastern Finland3, Imperial College London4, University of Lausanne5, University of Gothenburg6, deCODE genetics7, Boston University8, Broad Institute9, Boston Children's Hospital10, Wellcome Trust Sanger Institute11, Cedars-Sinai Medical Center12, University of Maryland, Baltimore13, Washington University in St. Louis14, University College London15, Reykjavík University16, National Institutes of Health17, University of Helsinki18, King's College London19, Karolinska Institutet20, University of Washington21, University of Edinburgh22, University of Texas Southwestern Medical Center23, Harvard University24, Lund University25, Malmö University26, University of Cambridge27, Wake Forest University28, Uppsala University29, GlaxoSmithKline30, Newcastle University31, Spanish National Research Council32, University of Iceland33, Science for Life Laboratory34, Pacific Biosciences35, Sage Bionetworks36, University of Split37, United States Department of Veterans Affairs38, Albert Einstein College of Medicine39, Ludwig Maximilian University of Munich40
TL;DR: In this paper, a meta-analysis of associations between similar to 2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant independent loci in 39,576 individuals.
Abstract: Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between similar to 2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 x 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 x 10(-11)) and one near SPRY2 (P = 3 x 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
301 citations
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University of Iceland1, Lancaster University2, Royal Institute of Technology3, European Science Foundation4, Stockholm Resilience Centre5, International Social Science Council6, Trinity College, Dublin7, Environmental Change Institute8, École Normale Supérieure9, Charles III University of Madrid10, University of Strasbourg11
TL;DR: In this article, the authors formulate the need for an innovative research agenda based on a careful consideration of the changing human condition as linked to global environmental change, and call for a meaningful research agenda to acknowledge the profound implications of the advent of the Anthropocene epoch.
301 citations
Authors
Showing all 5561 results
Name | H-index | Papers | Citations |
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Albert Hofman | 267 | 2530 | 321405 |
Kari Stefansson | 206 | 794 | 174819 |
Ronald Klein | 194 | 1305 | 149140 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Unnur Thorsteinsdottir | 167 | 444 | 121009 |
Vilmundur Gudnason | 159 | 837 | 123802 |
Hakon Hakonarson | 152 | 968 | 101604 |
Bernhard O. Palsson | 147 | 831 | 85051 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Fernando Rivadeneira | 146 | 628 | 86582 |
Rattan Lal | 140 | 1383 | 87691 |
Jonathan G. Seidman | 137 | 563 | 89782 |
Christine E. Seidman | 134 | 519 | 67895 |
Augustine Kong | 134 | 237 | 89818 |
Timothy M. Frayling | 133 | 500 | 100344 |