Showing papers by "University of Ioannina published in 1986"
215 citations
TL;DR: The glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal Hla-DR expression was found.
Abstract: Minor salivary gland biopsy specimens from patients with Sjogren's syndrome (primary and secondary) and from normal controls were examined with the four step biotin-avidin-immunoperoxidase assay. The composition of the infiltrating cells was similar in patients with both primary and secondary Sjogren's syndrome, consisting primarily of T lymphocytes with predominance of T helper/inducer cells. B lymphocytes (Leu-14) were approximately 20-35% of the infiltrating lymphocytes, while only a few OKM1 (monocytes/macrophages) cells and Leu-7+ (natural killer; NK) cells were observed. The majority of infiltrating lymphocytes expressed HLA-DR antigens. In the biopsy specimens of the controls there were no infiltrates; the scattered lymphocytes, however, were also predominantly T lymphocytes. Finally, the glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal HLA-DR expression was found.
113 citations
TL;DR: The findings suggest that Sjögren's syndrome expresses, in addition to polyclonal B cell hyperreactivity, a monoclonal process in the absence of lymphoid neoplasia, and show that the extraglandular manifestations of the syndrome may be due to an immune complex-mediated pathology.
Abstract: The incidence and nature of cryoglobulins, as well as their correlation with the clinical and serologic picture of Sjogren's syndrome (SS), were studied in the sera of 30 consecutive primary SS patients. Sera from 29 patients with systemic lupus erythematosus, 58 patients with rheumatoid arthritis, and 125 healthy blood donors were also studied. It was shown that one-third of the patients with SS had cryoglobulinemia. These cryoglobulins were mixed monoclonal IgM immunoglobulins, whereas those observed in systemic lupus erythematosus and rheumatoid arthritis patients were mixed polyclonal. The nature of the cryoglobulins was demonstrated using high-resolution electrophoresis combined with immunofixation. The presence of cryoglobulins in the sera of SS patients correlated with extraglandular disease and with antibodies to Ro (SS-A) and IgM rheumatoid factor. SS patients with cryoglobulins had lower serum C4 levels than did patients without cryoglobulins. These findings suggest that SS expresses, in addition to polyclonal B cell hyperreactivity, a monoclonal process in the absence of lymphoid neoplasia. Further, they show that the extraglandular manifestations of the syndrome may be due to an immune complex-mediated pathology.
104 citations
TL;DR: The most common functional abnormality was diffuse interstitial lung disease (DILD) in patients with pSS (37.5 percent) and obstructive ventilatory defect in RA and sss patients (40 and 19 percent, respectively).
81 citations
TL;DR: In this paper, the neutral delay differential equation (∗) (d dt )[y(t) + py(t − τ)] + qy (t − σ) = 0, t ⩾ t 0, where τ, q, and σ are positive constants, while p ϵ (−∞, −1) ∪ (0, + ∞).
66 citations
TL;DR: In this article, it was shown that if qτ ≥ 0, p, τ, and σ are real numbers, then each of the following conditions implies that every solution of Eq. (1) is oscillatory:
Abstract: Consider the neutral differential equation where q≠0, p, τ, and σ are real numbers. Let y(t) be a nonoscillatory solution of Eq. (1). Then limtt→∞y(t) is determined for all cases, except: . Two conjectures (as well as evidence indicating their possible validity) are given to cover the missing cases i), ii), and iii). It is also shown that if qτ≧0, or if qτ<0 and p≧0, then each of the following conditions implies that every solution of Eq. (1) is oscillatory: .
59 citations
TL;DR: In this article, sufficient conditions are given for the occurrence of various types of asymptotic behavior in the solution of a class of n th order neutral delay differential equations, in the form of certain inequalities amongst the constants involved in the definition of the differential equations.
Abstract: Sufficient conditions are given for the occurrence of various types of asymptotic behaviour in the solution of a class of n th order neutral delay differential equations. The conditions are in the form of certain inequalities amongst the constants involved in the definition of the differential equations, and specify either oscillatory behavior, or asymptotic divergence, or solutions which converge to zero.
56 citations
TL;DR: In this paper, the effects of neutral scalar-lepton mixing in supersymmetric models are examined. Butterworth et al. show that lepton and flavor violating processes arising at the one-loop level for μ → e γ, μ → 3e, μμ ⇄ ee as well as for neutrinoless ββ-decay are suppressed for a general class of supersymmetry breaking parameters.
35 citations
TL;DR: For the period September 1984 to November 1985 water samples from the aquatic system of Ioannina basin were analyzed every second month for organochlorine and triazines pesticides as mentioned in this paper.
34 citations
TL;DR: The problem of loss of information due to the discretization of data and its estimate is studied for various measures of information as well as for Fisher's information matrix.
Abstract: The problem of loss of information due to the discretization of data and its estimate is studied for various measures of information. The results of Ghurye and Johnson (1981) are generalized and supplemented for the Csiszar and Renyi measures of information as well as for Fisher's information matrix.
32 citations
TL;DR: Adulteration of olive oil with very low levels (1-2%) of linoleic acid-rich oils can be unequivocally detected by reversed-phase high-performance liquid chromatography on columns packed with C18 alkyl bonded-phase particles.
TL;DR: The results indicate that although dopamine receptors on the nucleus accumbens neurons are involved in the mechanisms mediating locomotor behaviour, the locomotor stimulant effect of d-amphetamine is not exclusively dependent on intra-accumbens dopaminergic activity.
Abstract: Kainic acid injections into the nucleus accumbens in rats induced severe loss of neuronal perikarya and the presence of gliosis in its vicinity, without affecting more distant areas. Spontaneous locomotor activity was elevated in the lesioned rats. After a low dose of d-amphetamine (1.5 mg/kg) no significant differences in locomotor activity were found between lesioned and sham-operated rats, while the increase in locomotor activity normally induced by a moderate dose of apomorphine (1 mg/kg) was blocked in lesioned rats. These results indicate that although dopamine receptors on the nucleus accumbens neurons are involved in the mechanisms mediating locomotor behaviour, the locomotor stimulant effect of d-amphetamine is not exclusively dependent on intra-accumbens dopaminergic activity.
TL;DR: In this paper, the concentrations of detected molecules of azinphosmethyl, parathion-methyl, diazinon, carbofuran and carbaryl were found to follow a seasonal fluctuation with maxima during summer and minima during winter months.
TL;DR: In this paper, the equations of motion of two first approximation shell theories are derived for free vibrations of homogeneous isotropic non-circular cylindrical shells, including the effects of thickness shear deformation and rotatory inertia.
TL;DR: It is shown for the first time that aldehyde dehydrogenase activity is increased in cultured human hepatocytes and this biochemical property is preserved in human and rat hepatocyte cultures, despite the rather quick loss of the basal aldechemical activity.
Abstract: Aldehyde dehydrogenase was measured in primary cultures of hepatocytes obtained with a two-step collagenase perfusion either from human hepatic tissue or from livers of Fisher rats. Basal enzyme activity declines gradually as a function of time in culture, but remains at all times higher when measured with propionaldehyde and NAD (P/NAD) than with benzaldehyde and NADP (B/NADP). Treatment of the cultures with 2 microM of 3-methylcholanthrene for four days significantly increased the B-NADP activity of human and rat hepatocytes (tenfold and eightfold respectively). In human hepatocytes 3-methylcholanthrene increases also the P/NAD activity, but to a lesser extent (twofold), compared to the B/NADP activity. Due to the significant enhancement of B/NADP activity in cultures of human and rat hepatocytes after application of 3-methylcholanthrene, the initial difference in the basal activity levels between the P/NAD and B/NADP forms diminishes or, in the case of human hepatocytes, is even inverted. These results show for the first time that aldehyde dehydrogenase activity is increased in cultured human hepatocytes. This biochemical property is preserved in human and rat hepatocyte cultures, despite the rather quick loss of the basal aldehyde dehydrogenase activity.
TL;DR: The protozoan Tetrahymena pyriformis contains 4.2 ± 2.2 ng PAF/107 cells, the first report of a natural occurrence of PAF in a protozoa, and production is not influenced by different extracellular Ca2+.
TL;DR: In this article, a batch fermentation process for the production of ethanol from raisin using Zymomonas mobilis is described, which shows significant advantages in ethanol production compared with yeasts, such as, faster fermentation time and higher ethanol productivity and yield.
Abstract: A batch fermentation process for the production of ethanol from raisin usingZymomonas mobilis is described. This process shows significant advantages in ethanol production compared with yeasts, such as, faster fermentation time and higher ethanol productivity and yield. Moreover, fermentation of the raisin extracts byZ. mobilis gave three-fold higher ethanol productivity than of standard synthetic media of the same invert-sugar concentration.
TL;DR: Although the problem of determining the various optimum parameters of the GAOR method in the general case is very difficult to solve theoretically, the numerical examples show that a suitable exploitation of it may give much better results than the other basic iterative methods.
TL;DR: The Neurospora crassa am gene was used as a heterologous probe to identify clones from two independently constructed Aspergillus nidulans gene libraries and was concluded that it has cloned the A. ndulans gdhA gene.
Abstract: The Neurospora crassa am gene was used as a heterologous probe to identify clones from two independently constructed Aspergillus nidulans gene libraries. These clones have a common HindIII 1.85 kb fragment. This A. nidulans nucleotide stretch hybridises to a N. crassa 2.7 kb BamHI fragment of wild type DNA but not to a co-migrating fragment from the DNA of the N. crassa am132 deletion mutant. One A. nidulans clone was shown to complement the N. crasse am132 deletion strain. The N. crassa transformants show low levels (∼5%) of heterologous glutamate dehydrogenase activity. The A. nidulans gdhA gene was found to locate in N. crassa at both the “homologous” (i.e. am) site as well as non-nomologous sites. Partial nucleotide analysis of the fragment has revealed the 5′ end of the locus and considerable homology with the N. crassa am gene. We concluded that we have cloned the A. nidulans gdhA gene.
TL;DR: In this paper, a study of Ar + -sputtered MoS 2 (0001) before and after its interaction with gas and metal adsorbates was performed in an UHV system with LEED, AES, EELS and WF measurements.
TL;DR: In this paper, the diamino pyrimidine ligand 2,4-diamino-5(3,4,5'-trimethovybenvyl)pyrimidine trimethoprim (trim) reacts with K2PtCl4, RhCl3 and AuCl3 to give the solid compleves.
Abstract: The diamino pyrimidine ligand 2,4-diamino-5(3',4',5'-trimethovybenvyl)pyrimidine trimethoprim (trim) reacts with K2PtCl4, RhCl3 and AuCl3 to give the solid compleves (trimH)2[PtCl4], Pt(trim)2Cl2, Rh(trim)-(trimH)Cl4, Au(trim)Cl3 and Au(trim)3Cl3. Properties, conductance measurements and spectral (IR, electronic, nuclear magnetic resonance) data are discussed in terms of the nature of the bonding and the possible structural types. Trimethoprim acts as a bridging bidentate ligand, bonding through the amino groups.
TL;DR: The results support the postulate that the catabolism of lysosomal glycogen is controlled by those agents that regulate the catabolic activity of hyaloplasmic glycogen and changes in the activity of the lysOSomal enzyme acid alpha-1,4-glucosidase.
TL;DR: In this paper, a nouveaux criteres doscillation for des equations differentielles ordinaires sous-lineaires d'ordre 2 a coefficients alternes are presented.
Abstract: On etablit de nouveaux criteres d'oscillation pour des equations differentielles ordinaires sous-lineaires d'ordre 2 a coefficients alternes. On obtient ces criteres en utilisant une technique de moyenne integrale
TL;DR: By using the language of differential forms, which illuminates the structure of the gauge symmetries of string theories in a compact notational framework, this article clarified the relation between the Neveu-West-Nicolai-Schwarz formulation of the string field theories and that of Banks and Peskin.
TL;DR: It is concluded that the prepared sequential arginine‐containing polypeptides are plausible models for histone fractions, f3 and f2α1.
Abstract: The sequential polypeptides (L-Arg-X-Gly)n, where X represents amino acid residues Ala, Val, and Leu, were prepared as models of arginine-rich histones to be used in studying their structure and their interactions with DNA. The polymerization was carried out on the pentachlorophenyl active esters of the appropriate tripeptides, while the toluene-4-sulfonyl group was used for protecting the arginine guanido group. CD was employed to investigate the conformation of (L-Arg-X-Gly)n polymers in aqueous solutions, at different pH, as well as in trifluoroenthanol and hexafluoroisopropyl alcohol solutions. In aqueous solutions (at pH 7 and 12) the prepared sequential polymers behaved as a random coil. The CD spectra in various trifluoroethanol–water or hexafluoroisopropyl alcohol–water mixtures indicated that the degree of helical conformation of the studied polytripeptides increased in the order of Ala Val Leu. The opposite was true for the β-structure. Characteristics of β-turn are excluded from the poly(L-Arg-L-Leu-Gly), which assumed the most pronounced helical conformation. The poly(L-Arg-L-Val-Gly) exerts a significant preference to the β-turn structure compared to that of poly(L-Arg-L-Ala-Gly). Thus the probability for helical, β-structure or β-turn conformations of the polymers was analyzed in relation to the bulkiness and length, and to the special features of the X-residue side chain (β-branching). We concluded that the prepared sequential arginine-containing polypeptides are plausible models for histone fractions, f3 and f2α1.
TL;DR: The results show that the ‘bulkiness’ (average cross-sectional area or ‘plumpness’) of amino acid side chains is the dominant factor in determining the stain-excluding property of a DMS-fixed negatively stained collagen fibril as it is in unfixed collagen.
TL;DR: Potentiometric studies of the reaction between trinitrobenzenesulfonic acid (TNBS) and several amino acids with the TNBS electrode indicate that the reaction is first-order with respect to TNBS and amino acid concentration.
TL;DR: In this article, a geometrical upper limit for the stoichiometry of adsorption θ m (adsorbed molecules per metal surface atom) of CO on small fcc Pd crystallites of various regular shapes is calculated.
TL;DR: In this article, an equivalence between (optimum) convergent methods (1) and a class of Successive Overrelation (SOR) methods (2) is established.