Institution
University of Ioannina
Education•Ioannina, Greece•
About: University of Ioannina is a education organization based out in Ioannina, Greece. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 7654 authors who have published 20594 publications receiving 671560 citations. The organization is also known as: Panepistimio Ioanninon.
Papers published on a yearly basis
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Royal Botanic Gardens1, University of Ioannina2, University of León3, National University of Ireland, Galway4, University of Coimbra5, Royal Botanic Garden Edinburgh6, University of Vienna7, University of São Paulo8, University of Yaoundé I9, University of Sydney10, University of Minnesota11, Botanic Gardens Conservation International12, Royal Holloway, University of London13, Universidade Federal do Rio Grande do Sul14, Universidade Federal de Pelotas15, Federal University of Paraná16, University of Gothenburg17
192 citations
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TL;DR: The flavonoid luteolin inhibited tumor growth and angiogenesis in a murine xenograft model and abolished VEGF-induced activation of Akt, a downstream target of PI3K conveying both survival and mitotic downstream signals.
Abstract: In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a murine xenograft model. Furthermore, luteolin inhibited vascular endothelial growth factor (VEGF)-induced in vivo angiogenesis in the rabbit corneal assay. In agreement, luteolin inhibited both VEGF-induced survival and proliferation of human umbilical vein endothelial cells (HUVECs) with an IC(50) of about 5 mumol/L. Luteolin inhibited VEGF-induced phosphatidylinositol 3'-kinase (PI3K) activity in HUVECs, and this inhibition was critical for both the antisurvival and antimitotic affects of the compound. Indeed, luteolin abolished VEGF-induced activation of Akt, a downstream target of PI3K conveying both survival and mitotic downstream signals. Because overexpression of a constitutively active form of Akt rescued HUVECs only from the antisurvival effects of luteolin, the result indicated that luteolin targeted mainly the survival signals of the PI3K/Akt pathway. With regard to its antimitotic activity, luteolin inhibited VEGF-induced phosphorylation of p70 S6 kinase (S6K), a downstream effector of PI3K responsible for G(1) progression. Indeed, VEGF-induced proliferation of HUVECs was sensitive to rapamycin, an inhibitor of p70 S6K activation. Surprisingly, luteolin did not affect VEGF-induced phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases, a pathway that is considered important for the mitotic effects of VEGF. Thus, blockade of PI3K by luteolin was responsible for the inhibitory effects of the compound on VEGF-induced survival and proliferation of HUVECs. The antisurvival effects of luteolin were mediated via blockage of PI3K/Akt-dependent pathways, whereas inhibition of the PI3K/p70 S6K pathway mediated the antimitotic effects of the compound.
192 citations
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National Institutes of Health1, Centers for Disease Control and Prevention2, Tufts University3, University of Ioannina4, Erasmus University Rotterdam5, Harvard University6, University of Texas Health Science Center at Houston7, United States Department of Health and Human Services8, Duke University9, Boston University10, Northwestern University11, deCODE genetics12, Johns Hopkins University13, University of Michigan14, Memorial Sloan Kettering Cancer Center15, University of North Carolina at Chapel Hill16, Genetic Alliance17, Los Angeles County Department of Public Health18, Wayne State University19, University of California, San Francisco20, Wake Forest University21
TL;DR: A multidisciplinary workshop was convened by the National Institutes of Health and the Centers for Disease Control and Prevention to review the scientific foundation for using personal genomics in risk assessment and disease prevention and to develop recommendations for targeted research.
192 citations
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TL;DR: The derived Gd(III)-doped carbon dots show uniform particle size and gadolinium distribution and form stable dispersions in water, and exhibit bright fluorescence, strong T1-weighted MRI contrast and low cytotoxicity.
Abstract: We describe the synthesis of Gd(III)-doped carbon dots as dual fluorescence-MRI probes for biomedical applications. The derived Gd(III)-doped carbon dots show uniform particle size (3–4 nm) and gadolinium distribution and form stable dispersions in water. More importantly, they exhibit bright fluorescence, strong T1-weighted MRI contrast and low cytotoxicity.
191 citations
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TL;DR: In this paper, the effect of the fiber and copolymer content on the mechanical properties of the composites is discussed and the influence of manufacturing method (compression molding of non-woven mats and injection moulding of short fiber compounds) and processing conditions (cooling temperature and annealing) on mechanical properties is investigated.
191 citations
Authors
Showing all 7724 results
Name | H-index | Papers | Citations |
---|---|---|---|
John P. A. Ioannidis | 185 | 1311 | 193612 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Elio Riboli | 158 | 1136 | 110499 |
Mercouri G. Kanatzidis | 152 | 1854 | 113022 |
Dimitrios Trichopoulos | 135 | 818 | 84992 |
Gyorgy Vesztergombi | 133 | 1444 | 94821 |
Niki Saoulidou | 132 | 1065 | 81154 |
Apostolos Panagiotou | 132 | 1370 | 88647 |
Ioannis Evangelou | 131 | 1225 | 82178 |
Ioannis Papadopoulos | 129 | 1201 | 85576 |
Nikolaos Manthos | 129 | 1256 | 81865 |
Panagiotis Kokkas | 128 | 1234 | 81051 |
Costas Foudas | 128 | 1112 | 83048 |
Zoltan Szillasi | 128 | 1214 | 84392 |
Matthias Schröder | 126 | 1421 | 82990 |