Institution
University of Ioannina
Education•Ioannina, Greece•
About: University of Ioannina is a education organization based out in Ioannina, Greece. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 7654 authors who have published 20594 publications receiving 671560 citations. The organization is also known as: Panepistimio Ioanninon.
Papers published on a yearly basis
Papers
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TL;DR: Clinical information about the incidence of hyponatremia associated with specific drug treatment is reviewed and the underlying pathophysiologic mechanisms are discussed.
388 citations
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TL;DR: The notion of a bornological fuzzy linear space is given and some of the properties of such a space are investigated.
387 citations
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University of Ioannina1, Sun Yat-sen University2, University of Ulsan3, National University of Malaysia4, National Taiwan University5, Mayo Clinic6, Zhejiang University7, Yonsei University8, Hospital Kuala Lumpur9, National Health Research Institutes10, University of Texas MD Anderson Cancer Center11, St. Marianna University School of Medicine12, Kanazawa University13, University of Valencia14, Hebron University15, Kobe University16
TL;DR: These guidelines represent the consensus opinions reached by experts in the treatment of patients with mCRC identified by the Presidents of the oncological societies of Japan (JSMO), China, Korea, Malaysia, Singapore, Singapore and Taiwan.
386 citations
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TL;DR: The combined effect of modified atmosphere packaging and oregano essential oil, on the shelf-life of lightly salted cultured sea bream fillets stored under refrigeration was studied and inhibition in the TVBN and TMAN values was evident in the order MAP.
385 citations
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Thomas Jefferson University1, University of Ioannina2, Brown University3, Wills Eye Institute4, University of Texas Southwestern Medical Center5, University of Nebraska Medical Center6, University of North Carolina at Chapel Hill7, Baylor College of Medicine8, University of Kentucky9, University of Genoa10, University of Texas MD Anderson Cancer Center11, University of New South Wales12, Garvan Institute of Medical Research13
TL;DR: The findings suggest that the repertoire of human miRNAs is far more extensive than currently represented by public repositories and that there is a significant number of lineage- and/or tissue-specific mi RNAs that are uncharacterized.
Abstract: Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, we identified 3,707 statistically significant novel mature miRNAs at a false discovery rate of ≤0.05 arising from 3,494 novel precursors; 91.5% of these novel miRNAs were identified independently in 10 or more of the processed samples. Analysis of these novel miRNAs revealed tissue-specific dependencies and a commensurate low Jaccard similarity index in intertissue comparisons. Of these novel miRNAs, 1,657 (45%) were identified in 43 datasets that were generated by cross-linking followed by Argonaute immunoprecipitation and sequencing (Ago CLIP-seq) and represented 3 of the 13 tissues, indicating that these miRNAs are active in the RNA interference pathway. Moreover, experimental investigation through stem-loop PCR of a random collection of newly discovered miRNAs in 12 cell lines representing 5 tissues confirmed their presence and tissue dependence. Among the newly identified miRNAs are many novel miRNA clusters, new members of known miRNA clusters, previously unreported products from uncharacterized arms of miRNA precursors, and previously unrecognized paralogues of functionally important miRNA families (e.g., miR-15/107). Examination of the sequence conservation across vertebrate and invertebrate organisms showed 56.7% of the newly discovered miRNAs to be human-specific whereas the majority (94.4%) are primate lineage-specific. Our findings suggest that the repertoire of human miRNAs is far more extensive than currently represented by public repositories and that there is a significant number of lineage- and/or tissue-specific miRNAs that are uncharacterized.
381 citations
Authors
Showing all 7724 results
Name | H-index | Papers | Citations |
---|---|---|---|
John P. A. Ioannidis | 185 | 1311 | 193612 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Elio Riboli | 158 | 1136 | 110499 |
Mercouri G. Kanatzidis | 152 | 1854 | 113022 |
Dimitrios Trichopoulos | 135 | 818 | 84992 |
Gyorgy Vesztergombi | 133 | 1444 | 94821 |
Niki Saoulidou | 132 | 1065 | 81154 |
Apostolos Panagiotou | 132 | 1370 | 88647 |
Ioannis Evangelou | 131 | 1225 | 82178 |
Ioannis Papadopoulos | 129 | 1201 | 85576 |
Nikolaos Manthos | 129 | 1256 | 81865 |
Panagiotis Kokkas | 128 | 1234 | 81051 |
Costas Foudas | 128 | 1112 | 83048 |
Zoltan Szillasi | 128 | 1214 | 84392 |
Matthias Schröder | 126 | 1421 | 82990 |