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Institution

University of Iowa

EducationIowa City, Iowa, United States
About: University of Iowa is a education organization based out in Iowa City, Iowa, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 49229 authors who have published 109171 publications receiving 5021465 citations. The organization is also known as: UI & The University of Iowa.


Papers
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Journal ArticleDOI
TL;DR: The tod-C1C2BAD genes show significant homology to the reported nucleotide sequence for benzene dioxygenase and cis-1,2-dihydroxycyclohexa-3,5-diene dehydrogenase from P. putida 136R-3.

597 citations

Journal ArticleDOI
TL;DR: A new consensus sequence TXXBXXTBXXXTBB is described, where turns bring basic interacting amino acid residues into proximity, indicating that protein‐GAG interactions play a prominent role in cell‐cell interaction and cell growth.
Abstract: Although interactions of proteins with glycosaminoglycans (GAGs), such as heparin and heparan sulphate, are of great biological importance, structural requirements for protein-GAG binding have not been well-characterised. Ionic interactions are important in promoting protein-GAG binding. Polyelectrolyte theory suggests that much of the free energy of binding comes from entropically favourable release of cations from GAG chains. Despite their identical charges, arginine residues bind more tightly to GAGs than lysine residues. The spacing of these residues may determine protein-GAG affinity and specificity. Consensus sequences such as XBBBXXBX, XBBXBX and a critical 20 A spacing of basic residues are found in some protein sites that bind GAG. A new consensus sequence TXXBXXTBXXXTBB is described, where turns bring basic interacting amino acid residues into proximity. Clearly, protein-GAG interactions play a prominent role in cell-cell interaction and cell growth. Pathogens including virus particles might target GAG-binding sites in envelope proteins leading to infection.

597 citations

Journal ArticleDOI
TL;DR: The observation of a small but consistent increase in preeclampsia is a conservative indication of a true population-level change in the United States, and may be exaggerated because of the revised clinical guidelines published in the 1990s.

596 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used observations from the Cheeka Peak Observatory in northwestern Washington State during March-April, 1997, to show that Asian anthropogenic emissions significantly impact the concentrations of a large number of atmospheric species in the air arriving to North America during spring.
Abstract: Using observations from the Cheeka Peak Observatory in northwestern Washington State during March-April, 1997, we show that Asian anthropogenic emissions significantly impact the concentrations of a large number of atmospheric species in the air arriving to North America during spring. Isentropic back-trajectories can be used to identify possible times when this impact will be felt, however trajectories alone are not sufficient to indicate the presence of Asian pollutants. Detailed chemical and meteorological data from one of these periods (March 29th, 1997) indicates that the surface emissions were lifted into the free troposphere over Asia and then transported to North America in ∼6 days.

596 citations

Journal ArticleDOI
TL;DR: Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages, and help define key evolutionary events within vertebrate lineages.
Abstract: Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provide insight into the ancestry of vertebrate genomes and the underlying principles of vertebrate biology. Here, we present the first lamprey whole-genome sequence and assembly. We note challenges faced owing to its high content of repetitive elements and GC bases, as well as the absence of broad-scale sequence information from closely related species. Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages. Moreover, the results help define key evolutionary events within vertebrate lineages, including the origin of myelin-associated proteins and the development of appendages. The lamprey genome provides an important resource for reconstructing vertebrate origins and the evolutionary events that have shaped the genomes of extant organisms.

596 citations


Authors

Showing all 49661 results

NameH-indexPapersCitations
Stephen V. Faraone1881427140298
Jie Zhang1784857221720
D. M. Strom1763167194314
Bradley T. Hyman169765136098
John H. Seinfeld165921114911
David Jonathan Hofman1591407140442
Stephen J. O'Brien153106293025
John T. Cacioppo147477110223
Mark Raymond Adams1471187135038
E. L. Barberio1431605115709
Andrew Ivanov142181297390
Stephen J. Lippard141120189269
Russell Richard Betts140132395678
Barry Blumenfeld1401909105694
Marcus Hohlmann140135694739
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023154
2022727
20214,128
20203,902
20193,763
20183,659