University of Iowa

About: University of Iowa is a education organization based out in Iowa City, Iowa, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 49229 authors who have published 109171 publications receiving 5021465 citations. The organization is also known as: UI & The University of Iowa.

Collision warning timing, driver distraction, and driver response to imminent rear-end collisions in a high-fidelity driving simulator.

Abstract: Rear-end collisions account for almost 30% of automotive crashes. Rear-end collision avoidance systems (RECASs) may offer a promising approach to help drivers avoid these crashes. Two experiments performed using a high-fidelity motion-based driving simulator examined driver responses to evaluate the efficacy of a RECAS. The first experiment showed that early warnings helped distracted drivers react more quickly--and thereby avoid more collisions--than did late warnings or no warnings. Compared with the no-warning condition, an early RECAS warning reduced the number of collisions by 80.7%. Assuming collision severity is proportional to kinetic energy, the early warning reduced collision severity by 96.5%. In contrast, the late warning reduced collisions by 50.0% and the corresponding severity by 87.5%. The second experiment showed that RECAS benefits even undistracted drivers. Analysis of the braking process showed that warnings provide a potential safety benefit by reducing the time required for drivers to release the accelerator. Warnings do not, however, speed application of the brake, increase maximum deceleration, or affect mean deceleration. These results provide the basis for a computational model of driver performance that was used to extrapolate the findings and identify the most promising parameter settings. Potential applications of these results include methods for evaluating collision warning systems, algorithm design guidance, and driver performance model input.

Multiple pathways to conscience for children with different temperaments: from toddlerhood to age 5.

Abstract: This research extends longitudinally findings on child temperament as a moderator of the impact of socialization on conscience development, reported previously for contemporaneous data at toddler age. Children's temperament and maternal socialization at Time 1 (n = 103, aged 2-3 years) were considered predictors of future conscience, assessed using new observational and narrative measures. The moderation model was supported for predicting conscience at Time 2 (n = 99, age 4), and, to a lesser extent, at Time 3 (n = 90, age 5). For children fearful as toddlers, maternal gentle discipline, presumably capitalizing on the optimal level of anxious arousal, promoted conscience at Time 2. For children fearless as toddlers, perhaps insufficiently aroused by gentle discipline, alternative socialization mechanisms, presumably capitalizing on mother-child positive orientation (secure attachment, maternal responsiveness), promoted conscience at Times 2 and 3. Developmental interplay of temperament and socialization in emerging morality is discussed.

Predictive Relationships for Uptake of Organic Contaminants by Hybrid Poplar Trees

Abstract: Twelve organic compounds commonly found at hazardous waste sites were studied for uptake by hybrid poplar trees. The vegetative uptake of many of these compounds has not previously been demonstrated for plant species being utilized for phytoremediation, such as hybrid poplar trees. Experiments were conducted hydroponically utilizing 14C-labeled compounds to ascertain translocation and fate. Predictive relationships for the translocation and partitioning to plant tissues were developed from the experimental data. Translocation and partitioning relationships based on compounds' octanol−water partitioning coefficients (log Kow) produced the best results, but the relationships did not allow for fully accurate prediction of each contaminant's fate. Translocation and subsequent transpiration of volatile organic compounds (VOCs) from the leaves to the atmosphere was shown to be a significant pathway. As full-scale phytoremediation systems are deliberated, the pathways investigated here should be considered in te...

Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices.

Abstract: The dynamics of microglial cell activation was studied in freshly prepared rat brain tissue slices. Microglia became activated in the tissue slices, as evidenced by their conversion from a ramified to amoeboid form within several hours in vitro. To define better the cytoarchitectural dynamics underlying microglial activation, we performed direct three-dimensional time-lapse confocal imaging of microglial cells in live brain slices. Microglia in tissue slices were stained with a fluorescent lectin conjugate, FITC-IB(4), and stacks of confocal optical sections through the tissue were collected repeatedly at intervals of 2-5 min for several hours at a time. Morphometric analysis of cells from time-lapse sequences revealed that ramified microglia progress to amoeboid macrophages through a stereotypical sequence of steps. First, in the withdrawal stage, the existing ramified branches of activating microglia do not actively extend or engulf other cells, but instead retract back (mean rate, 0.5-1.5 microm/min) and are completely resorbed into the cell body. Second, in the motility stage, a new set of dynamic protrusions, which can exhibit cycles of rapid extension and retraction (both up to 4 microm/min), abruptly emerges. Sometimes new processes begin to emerge even before the old branches are completely withdrawn. Third, in the locomotory stage, microglia begin translocating within the tissue (up to 118 microm/h) only after the new protrusions emerge. We conclude that the rapid conversion of resting ramified microglia to active amoeboid macrophages is accomplished not by converting quiescent branches to dynamic ones, but rather by replacing existing branches with an entirely new set of highly motile protrusions. This suggests that the ramified branches of resting microglia are normally incapable of rapid morphological dynamics necessary for activated microglial function. More generally, our time-lapse observations identify changes in the dynamic behavior of activating microglia and thereby help define distinct temporal and functional stages of activation for further investigation.

An interdisciplinary expert consensus statement on assessment of pain in older persons

Abstract: This paper represents an expert-based consensus statement on pain assessment among older adults. It is intended to provide recommendations that will be useful for both researchers and clinicians. Contributors were identified based on literature prominence and with the aim of achieving a broad representation of disciplines. Recommendations are provided regarding the physical examination and the assessment of pain using self-report and observational methods (suitable for seniors with dementia). In addition, recommendations are provided regarding the assessment of the physical and emotional functioning of older adults experiencing pain. The literature underlying the consensus recommendations is reviewed. Multiple revisions led to final reviews of 2 complete drafts before consensus was reached.