University of Iowa

About: University of Iowa is a education organization based out in Iowa City, Iowa, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 49229 authors who have published 109171 publications receiving 5021465 citations. The organization is also known as: UI & The University of Iowa.

Knowledge transfer through inheritance: spin- out generation, development, and survival

Abstract: We investigated how the knowledge capabilities of industry incumbents affected the generation, development, and performance of “spin-outs” (entrepreneurial ventures of ex-employees). Analyses of 1977–97 data from the disk drive industry supported our hypothesis that incumbents with both strong technological and market pioneering know-how generate fewer spin-outs than firms with strength in only one of these areas. Also, an incumbent’s capabilities at the time of a spin-out’s founding positively affect the spin-out’s knowledge capabilities and its probability of survival.

Conditions under Which Mean Square Ratios in Repeated Measurements Designs Have Exact F-Distributions

Abstract: Investigation is made of the character of the covariance matrix which will result in exact F-distributions for the treatments and interaction variance ratios in repeated measurements designs. It is shown, assuming multivariate normality, that the matrix may exhibit a more general character than is typically implied to be essential. Equality of variances and equality of covariances, with identical matrices for all levels of a second treatment factor, are sufficient but not necessary conditions. The necessary and sufficient condition is the equality of variances of differences for all pairs of treatment measures assumed to be correlated. An alternative statement is that the Box-Geisser-Greenhouse parameter e = 1.0. A test is described which bears on the tenability of this condition.

THE β-KETOADIPATE PATHWAY AND THE BIOLOGY OF SELF-IDENTITY

Abstract: The beta-ketoadipate pathway is a chromosomally encoded convergent pathway for aromatic compound degradation that is widely distributed in soil bacteria and fungi. One branch converts protocatechuate, derived from phenolic compounds including p-cresol, 4-hydroxybenzoate and numerous lignin monomers, to beta-ketoadipate. The other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. Enzyme studies and amino acid sequence data indicate that the pathway is highly conserved in diverse bacteria, including Pseudomonas putida, Acinetobacter calcoaceticus, Agrobacterium tumefaciens, Rhodococcus erythropolis, and many others. The catechol branch of the beta-ketoadipate pathway appears to be the evolutionary precursor for portions of the plasmid-borne ortho-pathways for chlorocatechol degradation. However, accumulating evidence points to an independent and convergent evolutionary origin for the eukaryotic beta-ketoadipate pathway. In the face of enzyme conservation, the beta-ketoadipate pathway exhibits many permutations in different bacterial groups with respect to enzyme distribution (isozymes, points of branch convergence), regulation (inducing metabolites, regulatory proteins), and gene organization. Diversity is also evident in the behavioral responses of different bacteria to beta-ketoadipate pathway-associated aromatic compounds. The presence and versatility of transport systems encoded by beta-ketoadipate pathway regulons is just beginning to be explored in various microbial groups. It appears that in the course of evolution, natural selection has caused the beta-ketoadipate pathway to assume a characteristic set of features or identity in different bacteria. Presumably such identities have been shaped to optimally serve the diverse lifestyles of bacteria.