Showing papers by "University of Jena published in 1987"
TL;DR: These characterizations lead to a linear time recognition algorithm, and to polynomial time algorithms for a number of NP-complete problems when restricted to graphs in this class of bipartite permutation graphs.
250 citations
151 citations
TL;DR: In this article, the collective excitations of a double heterostructure are examined in detail, including the important effects of the interfaces of the system the uncoupled modes are analyzed, which are the long-wave optical interface phonon modes, LO phonon mode, and intra-and inter-subband plasmon modes.
Abstract: The collective excitations of a double heterostructure are examined in detail. Including the important effects of the interfaces of the system the uncoupled modes are analysed, which are the long-wave optical interface phonon modes, LO phonon modes, and intra- and intersubband plasmon modes. The electron-phonon interaction is discussed and the coupling functions are calculated and discussed in graphical form. The resulting coupled modes, intra- and intersubband plasmon-phonon modes, are calculated for different approximations of the polarization function, the random-phase approximation, the plasmon-pol approximation, and the long-wave approximation. The dispersion curves of these modes are presented in graphical form for various cases. It is shown that the Landau damping of the modes strongly depends on the layer thickness and the concentration of the quasi-two-dimensional electron gas.
Die kollektiven Anregungen einer Doppelheterostruktur werden ausfuhrlich untersucht. Es werden die ungekoppelten Moden, d. h. die langwellig-optischen Grenzflachen-Phononen, die LO-Phononen sowie die Intra- und Intersubband-Plasmonen unter Einbeziehung der Grenzflacheneffekte diskutiert. Im Detail werden die Elektron-Phonon-Wechselwirkung analysiert, die Kopplungs-funktionen berechnet und graphisch dargestellt. Die resultierenden gekoppelten Moden, die Intra- und Intersubband-Plasmon-Phononen werden fur mehrere Naherung der Polarisationsfunktion, der Random-Phase-Approximation, der Plasmon-Pol-Naherung und der langwelligen Naherung berechnet. Die Dispersionskurven sind fur verschiedene Falle graphisch dargestellt. Es wird ge-zeigt, das die Landau-Dampfung der Moden stark von der Schichtdicke und der Konzentration des quasi-zweidimensionalen Elektronengases abhangt.
102 citations
TL;DR: It is shown that the effect of the optical instruments may be taken into account by introducing an apparatus function in a way which formally corresponds to that of classical optics, but the calculation of the corresponding convolution integrals is governed by operator ordering rules, which are essential in the case of quantum light fields.
Abstract: A quantum optical formulation of the action of passive, lossless optical instruments on quantum light fields is developed. The quantum Maxwell equations are formally solved and the commutation relations for various combinations of field operators at different times are studied. General relationships between field correlation functions and correlation functions of source-quantity operators and free-field operators are derived. Formulas are presented for the case when the free field is the vacuum field. Furthermore, the mixing of source-field light with coherent free-field light is treated. The theory is applied to the calculation of the photocount distribution. The theory presented renders it possible to take into account the effects of light propagation through the optical system. It is shown that the effect of the optical instruments may be taken into account by introducing an apparatus function in a way which formally corresponds to that of classical optics. However, the calculation of the corresponding convolution integrals is governed by operator ordering rules, which are essential in the case of quantum light fields and which can give rise to substantial differences between classical and quantum optics.
101 citations
TL;DR: In this article, a class of subsets of ℝd which can be represented as locally finite unions of sets with positive reach is considered and a translative integral geometrical formula for curvature measures is proved.
Abstract: A class of subsets of ℝd which can berepresented as locally finite unions of sets with positive reach isconsidered. It plays a role in PDE's on manifolds with singularities.For such a set, the unit normal cycle (determining the d − 1curvature measures) is introduced as a (d − 1)-currentsupported by the unit normal bundle and its properties are established.It is shown that, under mild additional assumptions, the unit normalcycle (and, hence, also the curvature measures) of such a set can beapproximated by that of a close parallel body or, alternatively, by themirror image of that of the closure of the complement of the parallelbody (which has positive reach). Finally, the mixed curvature measuresof two sets of this class are introduced and a translative integralgeometric formula for curvature measures is proved.
95 citations
TL;DR: An algorithm with time bound O ( n 2 ) for the weighted independent domination problem on permutation graphs and an investigation of (weighted) dominating clique problems for several graph classes including an NP-completeness result for weakly triangulated graphs as well as polynomial time bounds are given.
82 citations
TL;DR: In this article, the singleparticle Hamiltonian of the electron-phonon interaction is discussed for semiconductor superlattices, and the coupling functions describing the modified Frohlich interaction of a single electron with the continuous field of polarization of the IBP's and LO phonons are discussed and presented in graphical form.
Abstract: The single-particle Hamiltonian of the electron–(long-wave optical) phonon interaction is discussed for semiconductor superlattices. In detail the dispersion relations are analyzed of long-wave optical phonons, i.e. of the interface-like bulk phonons (IBP's) and of longitudinal optical (LO) phonons, of the polar semiconductor superlattice. The IBP's are composed from ordinary interface phonons on adjacent interfaces coupling through their macroscopic electric fields to form a collective excitation of the whole superlattice. The coupling function of the electron–phonon interaction is calculated using a continuum theory. The coupling functions describing the modified Frohlich interaction of a single electron with the continuous field of polarization of the IBP's and LO phonons are discussed and presented in graphical form.
Es wird der Einteilchen-Hamilton-Operator der Elektron–(langwellig-optischen) Phonon-Wechselwirkung von Halbleiter-Supergittern diskutiert. Im Detail werden die Dispersionsrelationen langwellig-optischer Phononen, d. h. die der grenzflachenartigen Volumen-Phononen (IBP's) und der longitudinal-optischen (LO) Phononen, von polaren Halbleiter-Supergittern analysiert. Dabei stellen die IBP's kollektive Anregungen des gesamten Supergitters dar, die aus den einzelnen Grenzflachen-Phononen, lokalisiert an jeder einzelnen Grenzflache des Supergitters, durch die Kopplung der makroskopischen elektrischen Felder uber die Schichten hinweg, hervorgehen. Die Kopplungsfunktion der Elektron–Phonon-Wechselwirkung wird im Rahmen einer Kontinuumstheorie berechnet. Die Kopplungsfunktionen, welche die modifizierte Frohlich-Wechselwirkung eines einzelnen Elektrons mit dem Polarisationsfeld der IBP's und LO Phononen beschreiben, werden ausfuhrlich diskutiert und graphisch dargestellt.
71 citations
TL;DR: A wide variety of PPV derivatives have been synthesized and characterized by their electrochemical oxidation and reduction potentials as mentioned in this paper, and the knowledge of the redox potentials which reflect fundamental properties of conjugated polymers is essential for theoretical and practical reasons.
Abstract: The development of PPV-systems has moved from intractable powders to solution processible film-forming materials by introducing solubilizing phenyl groups. This opens new uses ranging from thin-film insulators, over photoconductive electrophotographic recording materials, to novel electroactive battery electrodes. In addition, the phenylated PPV may be utilized as a promising thin-film precursor for microstructured carbon patterns with a stable electrical conductivity (σ = 40 S/cm).
PPV is not a metal-like conductor, but rather a high-ohmic photoconductor with a band gap of 2.4 eV. It can be made highly conducting upon appropriate chemical or electrochemical treatment (σ= 10−4 − 103 S/cm).
The formation of coexisting polymeric ion radicals (polarons) and diions (bipolarons) is well understood in terms of the concept of chain segment redox reactions (ECS concept).
A wide variety of PPV derivatives has been synthesized and characterized by their electrochemical oxidation and reduction potentials. Substituents like phenyl, methoxy and cyano groups have a significant influence on the redox potentials of PPV as the standard polymer (EOx = 0.8 V, ERed = −1.7 V).
Thus, for poly(1,4-phenylene-1,2-diphenylvinylene) a broadening of the band gap up to 2.9 eV along with an increase of the oxidation potential up to 1.2 V is estimated.
The knowledge of the redox potentials which reflect fundamental properties of conjugated polymers is essential for theoretical and practical reasons.
69 citations
TL;DR: The cytotoxic effect of the photosensitizer Methylene Blue activated with long wavelength laser radiation has been investigated using mice with solid Ehrlichcarcinomas and a significant tumor reduction has been achieved.
Abstract: The cytotoxic effect of the photosensitizer Methylene Blue activated with long wavelength laser radiation has been investigated using mice with solid Ehrlichcarcinomas. A krypton laser was used as a light source emitting laser radiation at 647 nm and 676 nm. The red spectral range is important for photochemotherapy because it is easily transmitted through tissue. A significant tumor reduction, including complete tumor destruction, has been achieved.
48 citations
TL;DR: The results demonstrate the occurrence of a PROC-like peptide in the mammalian nervous system, and these neurons seem to be at least largely identical to previously described TRH systems.
48 citations
TL;DR: In this article, the substituent distribution within the anhydroglucose and anhydroxylose units, respectively, in the systems N 2 O 4 -DMF-cellulose, and N 2 o 4 −DMF -SO 3 -xylan has been investigated.
TL;DR: In this article, the damping properties of surface polaritons, especially long-range surface plasmon-polaritons (LRSP) in asymmetric layer structures are analyzed taking into account the presence of a coupling prism.
Abstract: The damping properties of surface polaritons, especially long-range surface plasmon-polaritons (LRSP) in asymmetric layer structures are analyzed taking into account the presence of a coupling prism. Both, the response treatment to calculate attenuated-total-reflection (ATR) spectra and the virtual mode treatment are used. Two different types of virtual modes are analyzed. One of them describes the propagation properties of the surface polariton in the presence of both intrinsic and radiative damping. The other type describes a surface polariton with a driving field and hence this mode allows to find out the optimum conditions for the ATR experiment. These two modes are investigated in detail and the results of the numerical calculation are presented in graphical form. The results for the ATR configuration show that in asymmetric embedded silver layers the propagation length exceeds the value for the symmetric embedded one significantly.
Es werden die Dampfungseigenschaften von Oberflachen-Polaritonen, speziell Langstrecken-Oberflachen-Plasmon-Polaritonen in asymmetrischen Schichtstrukturen unter Einbeziehung der Existenz eines Koppelprismas analysiert. Es werden sowohl die Response-Theorie zur Berechnung der abgeschwachten Totalreflektionsspektren als auch das Konzept der virtuellen Moden verwendet. Zwei verschiedene Typen von virtuellen Moden werden analysiert. Eine von beiden beschreibt die Ausbreitungseigenschaften eines Oberflachen-Polaritons beim Vorhandensein sowohl von intrinsischer als auch Strahlungsdampfung. Der andere Typ beschreibt ein Oberflachen-Polariton mit einem oszillierenden Feld, womit es diese Mode ermoglicht, optimale Bedingungen fur ein Experiment der abgeschwachten Totalreflektion zu finden. Diese beiden Moden werden detailliert untersucht und die Resultate numerischer Rechnungen graphisch dargestellt. Die Ergebnisse fur eine Konfiguration zum Experiment der abgeschwachten Totalreflektion zeigen, das in asymmetrisch eingebotteten Silberschichten die Ausbreitungslange den Betrag fur die symmetrisch eingebettete Silberschicht deutlich uberschreitet.
TL;DR: In this article, it was shown that to each locally normal state of a boson system one can associate a point process that can be interpreted as the position distribution of the state.
Abstract: It is shown that to each locally normal state of a boson system one can associate a point process that can be interpreted as the position distribution of the state. The point process contains all information one can get by position measurements and is determined by the latter. On the other hand, to each so-called Σc-point processQ we relate a locally normal state with position distributionQ.
TL;DR: The energy budgets of wild populations of three Central European grasshopper species were calculated and summarized into diagrams, indicating different rates of food conversion and biomass and energy budgets and food utilization efficiencies of laboratory and wild populations.
Abstract: Biomass and energy budgets and food utilization efficiencies of laboratory and wild populations of three Central European grasshopper species, Chorthippus parallelus (Zetterstedt), C. biguttulus (L.), and Gomphocerus rufus (L.), were studied between 1979 and 1984. Larval consumption is relatively low in C. biguttulus (C=4.3 kJ/ind.) compared with C. parallelus and G. rufus (4.9 kJ/ind.). In the adult phase (maturity) consumption rates of C. biguttulus and G. rufus (6.9 kJ/ind.) are similar, but higher in C. parallelus (7.3 kJ/ind.). The energy content decreases from the egg (23.2–24.3 J/mg dw) and body tissue (22.1–23.2 J/mg dw) to faeces (16.6–18.1 J/mg dw). The energy contents of faeces differ significantly between the species, indicating different rates of food conversion (on Dactylis glomerata). On average, the assimilation rates are about 30%, slightly lower in G. rufus. Approximate digestibility (A/C) ranges from 28.2 (G. rufus) to 35.7 (C. biguttulus) without great differences between larvae and adults. In contrast, the efficiency of conversion of ingested food (P/C) differs significantly between larval (10–11) and adult stages (3.4–3.6), and so to a much higher degree does the efficiency of conversion of digested food (P/A), from 30.3–33.5 in the larval to 9.5–14.9 in the adult period. Based on 5-year (C. parallelus) and 2-year studies (G. rufus) of the population dynamics and life tables, the energy budgets of wild populations were calculated and summarized into diagrams. Depending on the annually fluctuating densities, in both populations about 1%–2% of net primary production was consumed, and another 5%–9% was cut and dropped. The proportion of production of the grasshopper populations (body tissue) used for egg production differs in C. parallelus (28%) and G. rufus (44%). The energy cycling owing to energy storage in the living eggs amounts to 2%–3% of the total energy consumed by the population. The results are compared with the available data for grasshoppers in the literature.
TL;DR: The proposed modified scBradford method exhibits high specificity and simple applicability but allows also quantitative protein determination nearly independently of the nature of protein.
TL;DR: From X-ray videograms recorded by means of Siemens urography, four different urinary transport types could be distinguished as well as the duration of the contraction periods and the intervals between the PCS-contractions.
Abstract: This study is intended to elucidate the process of urinary transport through the pelvi-calyceal system (PCS). PCS-motility of a total of 28 PCS was qualitatively and quantitatively determined in 9 stone patients and 14 control persons by examination of contrast medium excretion. From X-ray videograms recorded by means of Siemens urography, four different urinary transport types could be distinguished as well as the duration of the contraction periods and the intervals between the PCS-contractions. In stone patients physiological types of urinary transport are less common (33%) than in control subjects (81.25%). In stone patients the PCS is often characterized by reduced or even absent motility. Calyceal reflux is usually found in the systolic phase of PCS-contractions, which may apparently be regarded as a physiological process.
TL;DR: In this paper, the authors used the model established by Vander Hart and Gutowsky for interpreting the spectrum of K2P2O5F2 and extended it to the case of nonaxial 31P chemical shielding tensors.
Abstract: 31P chemical shielding and indirect dipolar coupling data of the polycrystalline fluorophosphates K2PO3F, Na2PO3F, BaPO3F and K2P2O5F2 were obtained from broad-line and magic angle sample spinning 31P N.M.R. measurements at 109·3 MHz. The N.M.R. spectra are interpreted in terms of the model established by Vander Hart and Gutowsky. For interpreting the spectrum of K2P2O5F2 the theory was extended to the case of nonaxial 31P chemical shielding tensors. The values of the 31P shielding anisotropy Δσ and the asymmetry parameter η of the fluorophosphates are explained on the basis of the assumption that in phosphates the character of the chemical bond between phosphorus and bridging oxygen atoms (P-OB bond) is very similar to that between phosphorus and fluorine atoms (P-F bond). In addition, the directions of the principal axes of the shielding tensors with respect to the coordinate system of the fluorophosphate ions are discussed. As a result, further support was obtained for the assumption of the similarity ...
Journal Article•
TL;DR: In this article, a new set of classes of Turing polynomiales non deterministes for denombrement of Hausdorff generee par NP are proposed.
Abstract: Perfectionnement de la hierarchie de Hausdorff generee par NP. Les nouvelles classes permettent une exacte classification de la complexite de certains problemes de denombrement. Les classes sont caracterisees en termes de machines de Turing polynomiales non deterministes
TL;DR: Neonatal heart rate and its interaction with respiration were computerized by spectral and coherence analysis (FFT) to differentiate healthy newborns from newborns with mild neonatal risk and Respiratory Sinus Arrhythmia is diminished in newborns-at-risk.
TL;DR: The results confirm that high doses of Al induce toxic effects and damage the lysosomes in the liver, the spleen and the kidneys and indicate that the extent of lysOSomal damage correlates with dose and duration of Al loading.
Abstract: The influence of repeated aluminium (Al) administration (0.05 or 0.5 mg 100 g-1 b.w.t. i.p. 5 times weekly for 12 weeks) on the lysosomal enzymes N-acetyl-beta-D-glucosaminidase (beta-NAG) and beta-glucuronidase (beta-Gluc) in serum, liver, spleen and kidneys of adult female rats with intact kidneys, (NR), or following partial nephrectomy (5/6 NX) was investigated. After A1 loading, at the high dose only, the beta-NAG in serum and the free beta-NAG in liver, spleen and kidneys increased. Latent beta-NAG levels decreased in all three organs the effect being dose related. Following A1 loading no elevation in total enzyme activity was observed, with one exception. Depending on A1 doses the spleen of the non-operated animals, the liver of both groups of animals and the serum showed a decrease in beta-Gluc activity. No effect on beta-Gluc activity was observed in the spleen of 5/6 NX animals or in the kidneys of either group of animals. The results confirm that high doses of Al induce toxic effects and damage the lysosomes in the liver, the spleen and the kidneys. The results indicate that the extent of lysosomal damage correlates with dose and duration of Al loading. Repeated administration of Al also interferes selectively with enzyme synthesis.
TL;DR: In this paper, it was shown that off-diagonal elements of the photon density matrix of a single-mode cavity field can be determined by using test atoms that are initially prepared in a coherent superposition of the two states interacting with the cavity mode.
Abstract: It is shown that off-diagonal elements of the photon density matrix of a single-mode cavity field can be determined by using test atoms that are initially prepared in a coherent superposition of the two states interacting with the cavity mode. In particular, this makes it possible to test the cavity field with respect to squeezing.
TL;DR: In this paper, the single-particle Hamiltonian of the electron-phonon interaction is discussed for semi-infinite semiconductor superlattices and the dispersion relation of the surface phonon modes is analyzed in detail.
Abstract: In this paper the single-particle Hamiltonian of the electron–(long-wave optical) phonon interaction is discussed for semi-infinite semiconductor superlattices. The dispersion relation of the (longwave optical) surface phonon modes is analyzed in detail. These modes are composed from ordinary interface phonons on adjacent interfaces coupling through their macroscopic electric fields to form a surface collective excitation of the whole structure with an electric field having an envelope function decaying exponentially from the surface of the semi-infinite superlattice. The coupling function of the electron–phonon interaction is calculated using a continuum theory. This coupling function describing the modified Frohlich interaction of a single electron with the continuous field of polarization of the surface phonons is discussed and presented in graphical form.
In dieser Arbeit wird der Einteilchen-Hamilton-Operator der Elektron–(langwellig-optisches) Phonon-Wechselwirkung von halbunendlichen Halbleiter-Supergittern diskutiert. Im Detail werden die Dispersionskurven der (langwellig-optischen) Oberflachen-Phononen analysiert. Diese Oberflachen-Phononen stellen kollektive Anregungen der gesamten Struktur mit von der Oberflache des halbunendlichen Supergitters abklingender Enveloppe-Funktion dar, die aus den einzelnen Grenzflachen-Phononen, lokalisiert an jeder einzelnen Grenzflache des Supergitters, durch Kopplung der makroskopischen elektrischen Felder uber die Schichten hinweg hervorgehen. Die Kopplungsfunktion der Elektron–Phonon-Wechselwirkung wird im Rahmen einer Kontinuumstheorie berechnet. Diese Kopplungsfunktion, welche die modifizierte Frohlich-Wechselwirkung eines einzelnen Elektrons mit dem Polarisationsfeld der Oberflachen-Phononen beschreibt, wird ausfuhrlich diskutiert und graphisch dargestellt.
TL;DR: In this article, le comportement asymptotique des valeurs propres d'operateurs integraux induits par des noyaux definis positifs qui satisfont certaines conditions de regularite sur des varietes compactes C ∞ a d dimensions is studied.
Abstract: On etudie le comportement asymptotique des valeurs propres d'operateurs integraux induits par des noyaux definis positifs qui satisfont certaines conditions de regularite sur des varietes compactes C ∞ a d dimensions
01 Apr 1987-Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms
TL;DR: In this paper, optical transmission and reflection spectroscopy in the near edge region in combination with chemical etching techniques and Rutherford backscattering (RBS) measurements are used to investigate the defect structures and their depth distribution in ion implanted GaAs as a function of the implantation conditions.
Abstract: Optical transmission and reflection spectroscopy in the near edge region in combination with chemical etching techniques and Rutherford backscattering (RBS) measurements are used to investigate the defect structures and their depth distribution in ion implanted GaAs as a function of the implantation conditions. The analysis of the measured data shows that for the amorphization of GaAs an overlap of the primarily created individual clusters is necessary in all cases investigated.
TL;DR: In benign tumors, the staining patterns for both antigens, in general, resembled their distribution in the corresponding normal tissues, however, carcinomas orginating from sweat glands, sebaceous glands, and the pilar apparatus expressed both antIGens in a more irregular and heterogeneous pattern.
Abstract: The expression of MAM-3 and MAM-6 antigens was immunohistochemically investigated on 110 tumors of human skin appendages. Forty-two samples from tumor-adjacent normal skin appendages were also studied. MAM-3 antigens, as detectable by monoclonal antibodies (MoAbs) 67D11, 115G3, and 115H10 were present in the inner layer cells but not in the outer layer cells of normal eccrine excretory ducts. Sporadic positivity was also found in cytoplasm of apocrine acini with 115G3, while 67D11 and 115H10 were negative. MAM-6 antigens, as detectable by the MoAbs 115D8, 115F5, 139H2, 140C1, and 126E7 were found in the secretory canaliculi of normal eccrine acini and within the apical lumina at the terminal portion of ducts. Apocrine acinar cells mainly exhibited an apical staining, but a focal supranuclear dot-like staining could also be observed. A foamy reaction pattern for MAM-6 was noted in mature sebocytes. However, none of the antigenic epitopes was expressed in normal squamous epithelium or hair follicles. In benign tumors, the staining patterns for both antigens, in general, resembled their distribution in the corresponding normal tissues. However, carcinomas orginating from sweat glands, sebaceous glands, and the pilar apparatus expressed both antigens in a more irregular and heterogeneous pattern. This might preferably be explained by the loss of those mechanisms controlling the antigen expression in mature, functional tissues. Conclusions from these immunohistochemical studies with regard to the histogenesis mainly of the malignant skin appendage tumors should be drawn with caution.
TL;DR: In this article, the decay of one massive conformally coupled scalar particle into two photons and the time-reversed decay according to the pi 0-2 gamma -model interaction in a spatially flat Robertson-Walker universe were investigated.
Abstract: The author investigates the decay of one massive conformally coupled scalar particle into two photons and the time-reversed decay according to the pi 0-2 gamma -model interaction in a spatially flat Robertson-Walker universe. Besides a few conceptual remarks concerning decay processes in pair-creating external fields, special attention is drawn to the problem of CPT non-invariance. It is found that both decay processes are not CPT invariant if (i) the expansion of the universe provides a T-asymmetric background and (ii) the conditions for free-particle creation are fulfilled for at least one of the quantum fields participating in the interaction. The results are illustrated for particular scale factors of the universe.
TL;DR: It is shown that BANDWIDTH can be solved in time O(n2) for interval graphs and that for a given interval graph a linear layout with minimum bandwidth can be constructed in time N2logn.
Abstract: An assignment of unique integers to the vertices of a graph is called a linear layout. The bandwidth minimization problem (BANDWIDTH) is the following: Given a graph G = (V, E) and an integer k, determine whether there exists a linear layout of G such that the maximum difference between adjacent vertices is bounded by k. Interval graphs are the intersection graphs of a family of intervals of the real line. BANDWIDTH remains NP-complete even when restricted to special subclasses of trees. We show that BANDWIDTH can be solved in time O(n2) for interval graphs. Moreover, for a given interval graph a linear layout with minimum bandwidth can be constructed in time O(n2logn). As a by-product we get that this construction can be done for proper interval graphs in time O(nlog n+m).
Journal Article•
TL;DR: After long-term administration of nitrate a significant decrease of serum somatomedin activity was found which also showed a positive correlation with a decrease of body weight gain.
Abstract: The effect of 2 days or 6 weeks administration of the diet containing 3 per cent potassium nitrate on serum level of thyroxine (T4), triiodothyronine (T3), nitrate, methemoglobin and somatomedin activity was investigated in piglets aged 56 days. Sufficient iodine intake by mothers prevented a decrease of T4 level in piglets after 2 days administration of nitrate. However, after 6 weeks of nitrate administration a striking decrease of T4 level was found (average level less than 10 nmol l-1) which could not be prevented even by the addition of 0.5 mg iodide per kg diet. No adaptation to nitrate administration was observed. After long-term administration of nitrate a significant decrease of serum somatomedin activity was found which also showed a positive correlation with a decrease of body weight gain.
TL;DR: Hepatocytes isolated from cirrhotic livers are ultrastructurally in a good state of preservation but they appear to be poorer than controls in RER membranes, although the well‐preserved mitochondria are somewhat richer in cristae.
Abstract: A technique is described for isolation of adult rat hepatocytes from micronodular cirrhotic livers based on a collagenase digestion procedure. Hepatocytes from normal livers and those chronically injured by thioacetamide did not differ with respect to the viability measured by the trypan blue exclusion test or to the cellular concentrations of protein and glycogen, but the triglyceride content of cells from cirrhotic livers was significantly reduced. Hepatocytes isolated from cirrhotic livers are ultrastructurally in a good state of preservation but they appear to be poorer than controls in RER membranes, although the well-preserved mitochondria are somewhat richer in cristae. No differences were detected between the cell preparations in rates of gluconeogenesis and total de novo fatty acid synthesis, but the secretion of newly synthesized fatty acids was significantly reduced in cells from cirrhotic livers. Thus adult rat hepatocytes can be isolated from thioacetamide-induced micronodular cirrhotic livers with high yield and morphological integrity. Differentiated functions are maintained in suspension for at least 4 h.