University of Jordan

About: University of Jordan is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Health care. The organization has 7796 authors who have published 13764 publications receiving 213526 citations.

The use of wild edible plants in the Jordanian diet.

Abstract: In Jordan, large numbers of wild edible plants are widely distributed throughout the country and consumed in various ways. In this study 56 wild edible plants used in local meals were surveyed to determine the plant parts used, the detailed methods of their preparation and preservation as well as their uses. The study showed that the plants used are either eaten raw, cooked by boiling in water, frying in fat or baking to be served as dishes such as stew, turnovers, stuffed and rolled vegetable foods or as cold or hot drinks for certain occasions and seasons. The study also showed that some of these plants are preserved by sun drying to be used out of season for cooking in main dishes, or as spices and appetizers.

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance.

Abstract: To determine a microsomal scaling factor for human liver suitable for prediction of in vivo drug clearance from in vitro data and to explore the role of inter-liver variability in this factor on the reported underprediction from microsomal parameters. Cytochrome P450 (henceforth P450) content in whole homogenates and microsomes from 38 donor livers was used to determine a microsomal scaling factor. In a subset (n = 20) of these preparations, individual P450 enzymes were examined by Western blotting and selective probe activities were determined. The scaling factor from 38 livers averaged 40 mg microsomal protein per gram liver with a coefficient of variation of 31%. Western blotting experiments indicated that there was no P450 enzyme-specific trend in the distribution of individual P450 enzymes in liver microsomes relative to whole homogenate. Predictions based on an average scaling factor resulted in a satisfactory prediction of intrinsic clearance of three benzodiazepines similar to that obtained using individual factors for the same livers. A value for human liver microsomal scaling of 40 mg microsomal protein per gram liver has been established. The reason for underprediction previously reported for 52 different drug substrates was not the use of an incorrect value for the scaling factor.

Black carrot (Daucus carota L.), dietary and health promoting perspectives of its polyphenols: A review

Abstract: The last few decades have witnessed a paradigm shift from the consumption of synthetic and processed foods towards natural food products because of their excellent health features. These trends are not only reshaping the approach to defend multiple ailments but also have opened avenues for scientific exploration to cure various physiological disorders.The present review primarily aims at spotlighting the presence of potential phytochemicals in black carrots (Daucus Carota L.) and their significant role in several major metabolic syndromes, such as cancer, cardiovascular diseases (CVD), diabetes mellitus, obesity, and oxidative stress-induced other malignancies. In addition, the current comprehensive review focuses on the chemistry and pharmacokinetics of black carrot polyphenols and proclaims black carrot anthocyanins as the major biological fractions to offer disease prevention and to some extent curative properties.In addition to its remarkable anthocyanins profile, black carrots are good source of a wide array of flavonoids evidently reported to avert a myriad of degenerative diseases. Health and therapeutic characteristics of these bioactive compounds call for further explorative studies and research endeavors to exploit this vegetable for prevention and cure of many diseases.