scispace - formally typeset
Search or ask a question
Institution

University of Jordan

EducationAmman, Jordan
About: University of Jordan is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Health care. The organization has 7796 authors who have published 13764 publications receiving 213526 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Ononis hirta (aerial parts) and Inula viscosa (flowers) extracts exerted their antiproliferative activity by inducing apoptosis in cancer cell lines by influencing cell death in Hep-2, MCF-7, and Vero cell lines.
Abstract: Forty four extracts from sixteen plants used traditionally as anticancer agents were evaluated in vitro for their antiproliferative activity against Hep-2, MCF-7, and Vero cell lines. Plants were fractionated using ethanol, methanol, chloroform, n-hexane, distilled water, and butanol. The antiproliferative activity was measured by MTT assay. TLC was used to identify active fractions. The apoptotic activity of active fractions was determined using TUNEL colorimetric assay. 20 of these extracts demonstrated significant antiproliferative activity against one or more of the cell lines. These extracts were prepared from Ononis hirta, Inula viscosa, Salvia pinardi, Verbascum sinaiticum and Ononis sicula. Methanol fractions of Ononis hirta (aerial parts) and Inula viscosa (flowers) were the most active fractions against MCF-7 cells with IC50 of 27.96 and 15.78 μg/ml respectively and they were less toxic against other cell lines. Other extracts showed lower activity against cancer cell lines. TLC analysis showed the presence of flavonoids and terpenoids in active plants while alkaloids were detected in Ononis hirta (aerial parts) extracts. Ononis hirta (aerial parts) and Inula viscosa (flowers) extracts exerted their antiproliferative activity by inducing apoptosis in cancer cell lines. Further studies are necessary for detailed chemical characterization and more extensive biological evaluation of the most active ingredients.

192 citations

Journal Article
TL;DR: Dexmedetomidine has a dose dependant effect on the onset and regression of sensory and motor block when used as an adjuvant to bupivacaine in spinal anesthesia.
Abstract: OBJECTIVES To determine the effect of adding dexmedetomidine to bupivacaine for neuraxial anesthesia. METHODS Sixty-six patients were studied between April and May 2008 in the University of Jordan, Amman Jordan. They were randomly assigned into 3 groups, each receiving spinal bupivacaine 12.5mg combined with normal saline (group N) Dexmedetomidine 5 microg (group D5), or dexmedetomidine 10 microg (group D10). The onset times to reach T10 sensory and Bromage 3 motor block, and the regression times to reach S1 sensory level and Bromage 0 motor scale, were recorded. RESULTS The mean time of sensory block to reach the T10 dermatome was 4.7 +/- 2.0 minutes in D10 group, 6.3 +/- 2.7 minutes in D5, and 9.5 +/- 3.0 minutes in group N. The mean time to reach Bromage 3 scale was 10.4 +/- 3.4 minutes in group D10, 13.0+/-3.4 minutes in D5, and 18.0 +/- 3.3 minutes in group N. The regression time to reach S1 dermatome was 338.9 +/- 44.8 minutes in group D10, 277.1 +/- 23.2 minutes in D5, and 165.5 +/- 32.9 minutes in group N. The regression to Bromage 0 was 302.9 +/- 36.7 minutes in D10, 246.4 +/- 25.7 minutes in D5, and 140.1 +/- 32.3 minutes in group N. Onset and regression of sensory and motor block were highly significant (N vesus D5, N versus D10, and D5 versus D10, p<0.001). CONCLUSIONS Dexmedetomidine has a dose dependant effect on the onset and regression of sensory and motor block when used as an adjuvant to bupivacaine in spinal anesthesia.

191 citations

Journal ArticleDOI
TL;DR: In this article, the possibility of processing roasted carob powder using different time-temperature combinations has been studied and the physical and chemical characteristics of the prepared carob powders were also examined.

191 citations

Journal ArticleDOI
TL;DR: A comparative study of two highly conserved duplicated genes, ARABIDOPSIS TRITHORAX-LIKE PROTEIN1 (ATX1) and ATX2, revealed features of both partial redundancy and of functional divergence.
Abstract: Gene duplication followed by functional specialization is a potent force in the evolution of biological diversity. A comparative study of two highly conserved duplicated genes, ARABIDOPSIS TRITHORAX-LIKE PROTEIN1 (ATX1) and ATX2, revealed features of both partial redundancy and of functional divergence. Although structurally similar, their regulatory sequences have diverged, resulting in distinct temporal and spatial patterns of expression of the ATX1 and ATX2 genes. We found that ATX2 methylates only a limited fraction of nucleosomes and that ATX1 and ATX2 influence the expression of largely nonoverlapping gene sets. Even when coregulating shared targets, ATX1 and ATX2 may employ different mechanisms. Most remarkable is the divergence of their biochemical activities: both proteins methylate K4 of histone H3, but while ATX1 trimethylates it, ATX2 dimethylates it. ATX2 and ATX1 provide an example of separated K4 di from K4 trimethyltransferase activity.

190 citations

Journal ArticleDOI
TL;DR: The development of SPE and HPLC methods for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma can serve as a standard method for the plasma determination therefore saving time, effort and money.

190 citations


Authors

Showing all 7905 results

NameH-indexPapersCitations
Yousef Khader94586111094
Crispian Scully8691733404
Debra K. Moser8555827188
Pierre Thibault7733217741
Ali H. Nayfeh7161831111
Harold S. Margolis7119926719
Gerrit Hoogenboom6956024151
Shaher Momani6430113680
Robert McDonald6257717531
Kaarle Hämeri5817510969
James E. Maynard561419158
E. Richard Moxon5417610395
Liam G Heaney532348556
Stephen C. Hadler5214811458
Nicholas H. Oberlies522629683
Network Information
Related Institutions (5)
King Saud University
57.9K papers, 1M citations

93% related

King Abdulaziz University
44.9K papers, 1.1M citations

93% related

Cairo University
55.5K papers, 792.6K citations

88% related

University of Catania
41.1K papers, 1M citations

87% related

University of Salerno
28.6K papers, 698K citations

87% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202334
2022163
20211,459
20201,313
20191,166
2018932