Institution
University of Jordan
Education•Amman, Jordan•
About: University of Jordan is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Health care. The organization has 7796 authors who have published 13764 publications receiving 213526 citations.
Papers published on a yearly basis
Papers
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01 Aug 2020TL;DR: A new definition of fuzzy fractional derivative, so-called fuzzy conformable, is proposed and the reproducing kernel Hilbert space method in the conformable emotion is constructed side by side with numerical results, tabulated data, and graphical representations.
Abstract: The aim of this article is to propose a new definition of fuzzy fractional derivative, so-called fuzzy conformable. To this end, we discussed fuzzy conformable fractional integral softly. Meanwhile, uniqueness, existence, and other properties of solutions of certain fuzzy conformable fractional differential equations under strongly generalized differentiability are also utilized. Furthermore, all needed requirements for characterizing solutions by equivalent systems of crisp conformable fractional differential equations are debated. In this orientation, modern trend and new computational algorithm in terms of analytic and approximate conformable solutions are proposed. Finally, the reproducing kernel Hilbert space method in the conformable emotion is constructed side by side with numerical results, tabulated data, and graphical representations.
157 citations
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TL;DR: Hydrogen peroxide does not induce significant changes in tooth enamel organic and inorganic relative contents, and it whitens teeth just by oxidizing their organic matrix.
157 citations
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TL;DR: In this paper, a cross-sectional survey where the Disaster Preparedness Evaluation Tool (DPET®) was distributed to Jordanian RNs who work in three randomly selected Ministry of Health hospitals and two university hospitals was conducted to assess Jordanian RN's perceptions regarding their knowledge, skills, and preparedness for disaster management.
156 citations
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TL;DR: The first successful encapsulation of thymoquinone into liposome is described; which maintains stability, improves bioavailability and maintains its anticancer activity.
Abstract: Thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone) is a herbal-derived drug with potential chemopreventive and chemotherapeutic activity. However, thymoquinone suffers from high hydrophobicity causing poor solubility which limits its bioavailability and high lipophilicity causing poor formulation characteristics. Liposomes are versatile drug carriers that can be used to solve problems of drug solubility, instability, and bio-distribution. In this study, we were able to prepare thymoquinone-loaded liposomes (TQ-LP) and thymoquinone loaded in liposomes modified with Triton X-100 (XLP) with diameters of about 100 nm, and entrapment efficiency of more than 90% for TQ-LP and of 49.6% for XLP. The TQ-LP liposomes were effective in suppressing the proliferation of breast cancer cell lines MCF-7 and T47D, and at the same time exerting very low toxicity on normal periodontal ligament fibroblast. Altogether, this report describes the first successful encapsulation of thymoquinone into liposome; which maintains st...
156 citations
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Boston Children's Hospital1, Howard Hughes Medical Institute2, George Washington University3, Duke University4, Broad Institute5, University of Jordan6, King Abdulaziz Medical City7, Family Research Institute8, University of British Columbia9, King Saud University10, Loma Linda University Medical Center11
TL;DR: It is found that gtdc2 knockdown in zebrafish replicates all WWS features (hydrocephalus, ocular defects, and muscular dystrophy), strongly suggesting that GTDC2 mutations cause WWS.
Abstract: Whole-exome sequencing (WES), which analyzes the coding sequence of most annotated genes in the human genome, is an ideal approach to studying fully penetrant autosomal-recessive diseases, and it has been very powerful in identifying disease-causing mutations even when enrollment of affected individuals is limited by reduced survival. In this study, we combined WES with homozygosity analysis of consanguineous pedigrees, which are informative even when a single affected individual is available, to identify genetic mutations responsible for Walker-Warburg syndrome (WWS), a genetically heterogeneous autosomal-recessive disorder that severely affects the development of the brain, eyes, and muscle. Mutations in seven genes are known to cause WWS and explain 50%–60% of cases, but multiple additional genes are expected to be mutated because unexplained cases show suggestive linkage to diverse loci. Using WES in consanguineous WWS-affected families, we found multiple deleterious mutations in GTDC2 (also known as AGO61). GTDC2’s predicted role as an uncharacterized glycosyltransferase is consistent with the function of other genes that are known to be mutated in WWS and that are involved in the glycosylation of the transmembrane receptor dystroglycan. Therefore, to explore the role of GTDC2 loss of function during development, we used morpholino-mediated knockdown of its zebrafish ortholog, gtdc2. We found that gtdc2 knockdown in zebrafish replicates all WWS features (hydrocephalus, ocular defects, and muscular dystrophy), strongly suggesting that GTDC2 mutations cause WWS.
156 citations
Authors
Showing all 7905 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yousef Khader | 94 | 586 | 111094 |
Crispian Scully | 86 | 917 | 33404 |
Debra K. Moser | 85 | 558 | 27188 |
Pierre Thibault | 77 | 332 | 17741 |
Ali H. Nayfeh | 71 | 618 | 31111 |
Harold S. Margolis | 71 | 199 | 26719 |
Gerrit Hoogenboom | 69 | 560 | 24151 |
Shaher Momani | 64 | 301 | 13680 |
Robert McDonald | 62 | 577 | 17531 |
Kaarle Hämeri | 58 | 175 | 10969 |
James E. Maynard | 56 | 141 | 9158 |
E. Richard Moxon | 54 | 176 | 10395 |
Liam G Heaney | 53 | 234 | 8556 |
Stephen C. Hadler | 52 | 148 | 11458 |
Nicholas H. Oberlies | 52 | 262 | 9683 |