Institution
University of Jordan
Education•Amman, Jordan•
About: University of Jordan is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Health care. The organization has 7796 authors who have published 13764 publications receiving 213526 citations.
Papers published on a yearly basis
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TL;DR: The findings showed that SMA was a frequent practice among Jordanians, signifying the need for an educational campaign on the proper use of antibiotics in this population.
Abstract: Objective: To assess the extent of self-medication with antibiotics (SMA) in a Jordanian population, and to evaluate the sociodemographic factors affecting this behaviour.
110 citations
TL;DR: The present study contributes to the continuing discussion about why and how people engage in SNSs from different nations' cultures, especially after the critical roles of S NSs in so-called Arab Spring.
109 citations
TL;DR: In this article, the influence of windows on the energy balance of apartment buildings in Amman is investigated by using self developed simulation software (SDS) based on the ASHRAE tables for solar heat gain calculation and coaling load factor for latitude 32°, where Amman city is located.
109 citations
TL;DR: In this paper, the authors identified hGBP1/2 as important resistance factors against C. trachomatis infection in IFNG-stimulated human macrophages.
Abstract: Interferon γ (IFNG) is a key host response regulator of intracellular pathogen replication, including that of Chlamydia spp The antichlamydial functions of IFNG manifest in a strictly host, cell-type and chlamydial strain dependent manner. It has been recently shown that the IFNG-inducible family of immunity-related GTPases (IRG) proteins plays a key role in the defense against nonhost adapted chlamydia strains in murine epithelial cells. In humans, IFN-inducible guanylate binding proteins (hGBPs) have been shown to potentiate the antichlamydial effect of IFNG; however, how hGBPs regulate this property of IFNG is unknown. In this study, we identified hGBP1/2 as important resistance factors against C. trachomatis infection in IFNG-stimulated human macrophages. Exogenous IFNG reduced chlamydial infectivity by 50 percent in wild-type cells, whereas shRNA hGBP1/2 knockdown macrophages fully supported chlamydial growth in the presence of exogenous IFNG. hGBP1/2 were recruited to bacterial inclusions in human macrophages upon stimulation with IFNG, which triggered rerouting of the typically nonfusogenic bacterial inclusions for lysosomal degradation. Inhibition of lysosomal activity and autophagy impaired the IFNG-mediated elimination of inclusions. Thus, hGBP1/2 are critical effectors of antichlamydial IFNG responses in human macrophages. Through their capacity to remodel classically nonfusogenic chlamydial inclusions and stimulate fusion with autophagosomes, hGBP1/2 disable a major chlamydial virulence mechanism and contribute to IFNG-mediated pathogen clearance.
109 citations
TL;DR: Two cultivars each of spinach, lettuce, cabbage, squash, and cauliflowers, as well as one cultivar of parsley were grown in open fields, and the effects of cultivar and harvest date on the nitrate and nitrite content of the edible parts of these vegetables were studied.
109 citations
Authors
Showing all 7905 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Yousef Khader | 94 | 586 | 111094 |
| Crispian Scully | 86 | 917 | 33404 |
| Debra K. Moser | 85 | 558 | 27188 |
| Pierre Thibault | 77 | 332 | 17741 |
| Ali H. Nayfeh | 71 | 618 | 31111 |
| Harold S. Margolis | 71 | 199 | 26719 |
| Gerrit Hoogenboom | 69 | 560 | 24151 |
| Shaher Momani | 64 | 301 | 13680 |
| Robert McDonald | 62 | 577 | 17531 |
| Kaarle Hämeri | 58 | 175 | 10969 |
| James E. Maynard | 56 | 141 | 9158 |
| E. Richard Moxon | 54 | 176 | 10395 |
| Liam G Heaney | 53 | 234 | 8556 |
| Stephen C. Hadler | 52 | 148 | 11458 |
| Nicholas H. Oberlies | 52 | 262 | 9683 |