Institution
University of Jyväskylä
Education•Jyvaskyla, Finland•
About: University of Jyväskylä is a education organization based out in Jyvaskyla, Finland. It is known for research contribution in the topics: Population & Neutron. The organization has 8066 authors who have published 25168 publications receiving 725033 citations. The organization is also known as: Jyväskylän yliopisto & Kasvatusopillinen korkeakoulu.
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TL;DR: The data suggest that the effects of exercise on FNDC5 and irisin are not consistent, and that their role in health is questionable, and the regulatory mechanisms should be studied further.
Abstract: Recently, contradictory findings have been reported concerning the function of irisin and its precursor gene, skeletal muscle FNDC5, in energy homeostasis, and the associated regulatory role of exercise and PGC-1α. We therefore evaluated whether muscle FNDC5 mRNA and serum irisin are exercise responsive and whether PGC-1α expression is associated with FNDC5 expression. The male subjects in the study performed single exercises: (1) 1 h low-intensity aerobic exercise (AE) (middle-aged, n = 17), (2) a heavy-intensity resistance exercise (RE) bout (young n = 10, older n = 11) (27 vs. 62 years), (3) long-term 21 weeks endurance exercise (EE) training alone (twice a week, middle-aged, n = 9), or (4) combined EE and RE training (both twice a week, middle-aged, n = 9). Skeletal muscle mRNA expression was analysed by quantitative PCR and serum irisin by ELISA. No significant changes were observed in skeletal muscle PGC-1α, FNDC5 and serum irisin after AE, EE training or combined EE + RE training. However, a single RE bout increased PGC-1α by 4-fold in young and by 2-fold in older men, while FNDC5 mRNA only increased in young men post-RE, by 1.4-fold. Changes in PGC-1α or serum irisin were not consistently accompanied by changes in FNDC5. In conclusion, for the most part, neither longer-term nor single exercise markedly increases skeletal muscle FNDC5 expression or serum irisin. Therefore their changes in response to exercise are probably random and not consistent excluding the confirmation of any definitive link between exercise and FNDC5 expression and irisin release in humans. Moreover, irisin and FNDC5 were not associated with glucose tolerance and being overweight, or with metabolic disturbances, respectively. Finally, factor(s) other than PGC-1α and transcription may regulate FNDC5 expression.
258 citations
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Technische Universität München1, University of Hamburg2, Ohio State University3, Russian Academy of Sciences4, Karlsruhe Institute of Technology5, Harish-Chandra Research Institute6, Petersburg Nuclear Physics Institute7, Tata Institute of Fundamental Research8, Hawaii Pacific University9, University of Oulu10, University of Tübingen11, Max Planck Society12, Institut de Physique du Globe de Paris13, University of Jyväskylä14, University of Bucharest15, University of Hawaii16, University of Paris17, Drexel University18, University of Zurich19, University of Maryland, College Park20, Spanish National Research Council21, Instituto Superior Técnico22, Durham University23, George Mason University24, University of Helsinki25, RWTH Aachen University26, University of Ioannina27
TL;DR: In this paper, the authors proposed the liquid-scintillator detector LENA (Low Energy Neutrino Astronomy) as a multipurpose neutrino observatory.
258 citations
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TL;DR: In this paper, two normal metal/insulator/superconductor (NIS) tunnel junctions combined in series to form a symmetric SINIS structure can operate as an efficient Peltier refrigerator.
Abstract: We suggest and demonstrate in experiment that two normal metal/insulator/superconductor (NIS) tunnel junctions combined in series to form a symmetric SINIS structure can operate as an efficient Peltier refrigerator. Specifically, it is shown that the SINIS structure with normal‐state junction resistances 1.0 and 1.1 kΩ is capable of reaching a temperature of about 100 mK starting from 300 mK. We estimate the corresponding cooling power to be 1.5 pW per total junction area of 0.8 μm2 at T=300 mK.
258 citations
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TL;DR: Results of both studies revealed moderate stability for both school burnouts and depressive symptoms and showed that school burnout more strongly predicted subsequent depressive symptoms later on than vice versa.
Abstract: The main purpose of this study was to examine the extent to which middle and late adolescents' depressive symptoms predict their later school burnout and, in turn, the extent to which school burnout predicts depressive symptoms. Drawing on data gathered at ages 15-19 in two-three-wave longitudinal studies, we investigated cross-lagged paths between school burnout and depressive symptoms. In Study 1 the participants were 15-year-old adolescents (Time 1: N = 611, Time 2: N = 614, Time 3: N = 725) who completed the School Burnout Inventory and depressive symptoms twice during their final term of comprehensive school and once after the transition to upper secondary high school or vocational school. In Study 2 the participants were 17-year-old adolescents whose school burnout and depressive symptoms were measured three times annually (Time 1: N = 474, Time 2: N = 412, Time 3: N = 414) during their 3 years of secondary education. Results of both studies revealed moderate stability for both school burnout and depressive symptoms. They also showed that school burnout more strongly predicted subsequent depressive symptoms later on than vice versa. Lastly, they revealed cumulative cycles between school burnout and depressive symptoms.
258 citations
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TL;DR: In this paper, the PES spectra from aluminum cluster anions were studied using ab initio molecular dynamics simulations and experimentally, and the calculated spectra, obtained via shifting of the simulated electronic densities of states by the self-consistently determined values of the asymptotic exchange-correlation potential, agree well with the measured ones, allowing reliable structural assignments and theoretical estimation of the clusters' temperatures.
Abstract: Photoelectron (PES) spectra from aluminum cluster anions, ${\mathrm{Al}}_{n}^{\ensuremath{-}}$ $(12l~nl~15),$ at various temperature regimes, were studied using ab initio molecular dynamics simulations and experimentally. The calculated PES spectra, obtained via shifting of the simulated electronic densities of states by the self-consistently determined values of the asymptotic exchange-correlation potential, agree well with the measured ones, allowing reliable structural assignments and theoretical estimation of the clusters' temperatures.
258 citations
Authors
Showing all 8239 results
Name | H-index | Papers | Citations |
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Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Mika Kivimäki | 166 | 1515 | 141468 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Marvin Johnson | 149 | 1827 | 119520 |
Stanislas Dehaene | 149 | 456 | 86539 |
Roger Jones | 138 | 998 | 114061 |
Zubayer Ahammed | 129 | 912 | 59811 |
James Alexander | 129 | 886 | 75096 |
Matti J Kortelainen | 128 | 1186 | 80603 |
Madan M. Aggarwal | 124 | 883 | 56065 |
Joakim Nystrand | 117 | 658 | 50146 |
Robert U. Newton | 109 | 753 | 42527 |
Dieter Røhrich | 102 | 637 | 35942 |
Keijo Häkkinen | 99 | 421 | 31355 |
Dong Jo Kim | 98 | 497 | 36272 |