University of Kansas

About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.

A multidimensional structure for repetitive thought: what's on your mind, and how, and how much?

Abstract: Although repetitive thought (RT) styles such as worry, rumination, and processing correlate positively, they have divergent effects on well-being, suggesting important dimensional variation. In Study 1, multidimensional scaling identified 2 dimensions-positive versus negative content valence and searching versus solving purpose-among students (N = 978) who completed standard RT measures. In Study 2, students (N = 100) sorted 25 descriptions of RT. Multidimensional scaling identified 4 dimensions, including valence and purpose. Content valence associated with valenced affect; solving associated with less aroused affect and less polarized appraisals of thought topics. In Study 3, valence and purpose of RT descriptions by women in a breast cancer prevention trial (N = 62) predicted concurrent affect and psychological and physical well-being.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Abstract: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we provide recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017). It is meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.

A Critical, Objective Review of Performance Feedback

Abstract: Providing information to employees about their past performance is a widely used strategy in organizations. The effects of performance feedback, however, have not been previously systematically evaluated. A total of 126 applications of feedback in organizations was reviewed. Each feedback application was evaluated in terms of the consistency of its effects. Effects were differentiated according to whether feedback was used alone or in combination with rewards and/or goal setting procedures and according to selected characteristics of feedback. The results of this review indicate that (1) feedback does not uniformly improve performance; (2) adding rewards and/or goal setting procedures to feedback improves the consistency of its effects; and (3) some characteristics of feedback are more consistently associated with improved performance than others. An analysis of the ways in which feedback might operate and consideration of basic research suggest that it will be effective to the extent that it is ...

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate.

Abstract: The mechanisms of activation of the precursor of human matrix metalloproteinase 3 (proMMP-3/prostromelysin) by proteinases and (4-aminophenyl)mercuric acetate (APMA) were investigated by kinetic and sequence analyses. Incubation of proMMP-3 with neutrophil elastase, plasma kallikrein, plasmin, or chymotrypsin at 37 degrees C resulted in the formation of MMP-3 of Mr = 45,000 by cleaving of the His82-Phe83 bond. Since this bond is unlikely to be cleaved by these proteinases it was postulated that an initial attack of an activator proteinase on proMMP-3 creates an intermediate form, which is then processed to a more stable form of Mr = 45,000. To test this hypothesis proMMP-3 was incubated with these serine proteinases under conditions that minimize the action of MMP-3. This led to the accumulation of major intermediates of Mr = 53,000 and two minor forms of Mr = 49,000 and 47,000. The 53,000 Mr intermediate generated by human neutrophil elastase resulted from cleavage of the Val35-Arg36 whereas plasma kallikrein cleaved the Arg36-Arg37 and Lys38-Asp39 bonds and chymotrypsin the Phe34-Val35 bond, all of which are located near the middle of the propeptide. Conversion of these intermediates to the fully active 45,000 Mr form of MMP-3 resulted from a bimolecular reaction of the intermediates. A similar short-lived intermediate of Mr = 46,000 generated by APMA was a result of the intramolecular cleavage of the Glu68-Val69 bond, and it was then converted to a stable MMP-3 of Mr = 45,000 by a intermolecular reaction of MMP-3. However, MMP-3 failed to activate proMMP-3.(ABSTRACT TRUNCATED AT 250 WORDS)