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Institution

University of Kansas

EducationLawrence, Kansas, United States
About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.


Papers
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Journal ArticleDOI
TL;DR: Conceptual advances of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group guidance to evaluate the certainty of evidence from network meta-analysis (NMA) are described.

375 citations

Journal ArticleDOI
TL;DR: By defining these first principles of metastasis, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues.
Abstract: Metastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well as interactions between cancer cells and multiple microenvironments. The outcome is the development of a nearby or distant discontiguous secondary mass. To successfully disseminate, metastatic cells acquire properties in addition to those necessary to become neoplastic. Heterogeneity in mechanisms involved, routes of dissemination, redundancy of molecular pathways that can be utilized, and the ability to piggyback on the actions of surrounding stromal cells makes defining the hallmarks of metastasis extraordinarily challenging. Nonetheless, this review identifies four distinguishing features that are required: motility and invasion, ability to modulate the secondary site or local microenvironments, plasticity, and ability to colonize secondary tissues. By defining these first principles of metastasis, we provide the means for focusing efforts on the aspects of metastasis that will improve patient outcomes.

375 citations

Journal ArticleDOI
TL;DR: A critique of the literature, the own work, and various simulations suggests that drug release from cyclodextrin complexes is rapid and quantitative in most cases.

375 citations

Journal ArticleDOI
TL;DR: In this paper, the authors compare firms' capital structure adjustments across countries and investigate whether institutional differences help explain the variance in estimated adjustment speeds, finding that legal and financial traditions significantly correlate with firm adjustment speeds.

374 citations


Authors

Showing all 38401 results

NameH-indexPapersCitations
Gordon H. Guyatt2311620228631
Krzysztof Matyjaszewski1691431128585
Wei Li1581855124748
David Tilman158340149473
Tomas Hökfelt158103395979
Pete Smith1562464138819
Daniel J. Rader1551026107408
Melody A. Swartz1481304103753
Kevin Murphy146728120475
Carlo Rovelli1461502103550
Stephen Sanders1451385105943
Marco Zanetti1451439104610
Andrei Gritsan1431531135398
Gunther Roland1411471100681
Joseph T. Hupp14173182647
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022358
20214,211
20204,204
20193,766
20183,485