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Institution

University of Kansas

EducationLawrence, Kansas, United States
About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.


Papers
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Journal ArticleDOI
TL;DR: Delayed treatment with GSH and NAC protect against APAP overdose by dual mechanisms—that is, by enhancing hepatic and mitochondrial GSH levels (scavenging of reactive oxygen and peroxynitrite)—and by supporting the mitochondrial energy metabolism.

369 citations

Journal ArticleDOI
TL;DR: The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.
Abstract: The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies generated in the liver and lactate derived from exercising skeletal muscle can also become important energy substrates for the brain. In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progressive, region-specific and disease-specific manner — a problem that is best characterized in Alzheimer disease, where it begins presymptomatically. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes. Accumulating evidence indicates that impaired glucose metabolism in the brain is involved in the cause and progression of neurodegenerative disorders of ageing such as Alzheimer disease. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by rescuing, protecting or normalizing brain energetics.

369 citations

Journal ArticleDOI
TL;DR: New instruments to assess coping through emotional approach are developed and validated, demonstrating that items measuring emotion-focused strategies in published coping questionnaires are confounded with distress and self-deprecation.
Abstract: Researchers studying stress and coping processes have attempted to identify which coping strategies are most adaptive in stressful encounters. A generally accepted conclusion has been that emotion-focused coping processes are associated with dysfunctional outcomes. Studies from our and other research teams challenge the "bad reputation" of emotion-focused coping by demonstrating that items measuring emotion-focused strategies in published coping questionnaires are confounded with distress and self-deprecation. We have developed and validated new instruments to assess coping though acknowledging, understanding, and expressing emotion, that is, coping through emotional approach. Longitudinal and experimental studies using these new scales have documented the adaptive potential of emotional-approach coping in the context of several types of stressors, including infertility, breast cancer, and chronic pain. However, characteristics of the environmental context, stressful experience, and individual are important moderators of the relations of emotional-approach coping and health-related outcomes. Potential mediators and moderators of coping through emotional approach, clinical relevance of the construct, and directions for research are discussed.

368 citations

Journal ArticleDOI
01 May 1977-Cancer
TL;DR: There were no statistically significant differences in remission rates, durations of remission, or toxicities in the dose schedules studied, and unless rapid remission induction is urgent, the recommend 60 mg/m2 X four doses and measurement of myocardial function if treatment is to continue.
Abstract: Because patients treated with 60-90 mg/m2 every three to four weeks reach cardiotoxic doses of 550 mg/m2 within 36 weeks, prolonged treatment with Adriamycin is limited. The purpose of this study was to determine whether lower doses could be given over longer periods without loss of efficacy. Good risk patients treated with 75, 60, or 45 mg/m2 had remission rates of 25, 27, and 19%; poor risk patients treated with 50 and 25 mg/m2 had remission rates of 16 and 12% respectively. Although a dose response was identified, there were no statistically significant differences in remission rates, durations of remission, or toxicities in the dose schedules studied. Irreversible congestive heart failure occurred in five patients with cumulative doses of 240-390 mg/m2. Unless rapid remission induction is urgent, we recommend 60 mg/m2 X four doses and measurement of myocardial function if treatment is to continue.

368 citations

Journal ArticleDOI
15 Jan 2019-Fuel
TL;DR: In this paper, the authors comprehensively reviewed the CO2 injection enhanced oil recovery (EOR) and carbon storage related literature in shales over the past decade, including description of major shale reservoirs producing oil, selection of injection scheme, models applied to simulate gas injection, oil recovery mechanisms for different types of gas, molecular diffusion and its laboratory measurement, nanopore effect, adsorption effect on carbon storage and transport, laboratory work of gas injection in shale cores, pilot tests, and economic evaluation.

368 citations


Authors

Showing all 38401 results

NameH-indexPapersCitations
Gordon H. Guyatt2311620228631
Krzysztof Matyjaszewski1691431128585
Wei Li1581855124748
David Tilman158340149473
Tomas Hökfelt158103395979
Pete Smith1562464138819
Daniel J. Rader1551026107408
Melody A. Swartz1481304103753
Kevin Murphy146728120475
Carlo Rovelli1461502103550
Stephen Sanders1451385105943
Marco Zanetti1451439104610
Andrei Gritsan1431531135398
Gunther Roland1411471100681
Joseph T. Hupp14173182647
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022358
20214,211
20204,204
20193,766
20183,485