Institution
University of Kansas
Education•Lawrence, Kansas, United States•
About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.
Topics: Population, Poison control, Large Hadron Collider, Health care, Cancer
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the capabilities of the CERN Large Hadron Collider (LHC) experiment to explore the rich heavy-ion physics program offered by the LHC are presented, and the potential of the CMS experiment to carry out a series of representative Pb-Pb measurements.
Abstract: This report presents the capabilities of the CMS experiment to explore the rich heavy-ion physics programme offered by the CERN Large Hadron Collider (LHC). The collisions of lead nuclei at energies , will probe quark and gluon matter at unprecedented values of energy density. The prime goal of this research is to study the fundamental theory of the strong interaction ? Quantum Chromodynamics (QCD) ? in extreme conditions of temperature, density and parton momentum fraction (low-x).This report covers in detail the potential of CMS to carry out a series of representative Pb-Pb measurements. These include bulk observables, (charged hadron multiplicity, low pT inclusive hadron identified spectra and elliptic flow) which provide information on the collective properties of the system, as well as perturbative probes such as quarkonia, heavy-quarks, jets and high pT hadrons which yield tomographic information of the hottest and densest phases of the reaction.
361 citations
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TL;DR: The results implicate ERV enhancer co-option as a mechanism underlying the extensive evolutionary diversification of placental development.
Abstract: The mammalian placenta is remarkably distinct between species, suggesting a history of rapid evolutionary diversification. To gain insight into the molecular drivers of placental evolution, we compared biochemically predicted enhancers in mouse and rat trophoblast stem cells (TSCs) and found that species-specific enhancers are highly enriched for endogenous retroviruses (ERVs) on a genome-wide level. One of these ERV families, RLTR13D5, contributes hundreds of mouse-specific histone H3 lysine 4 monomethylation (H3K4me1)- and histone H3 lysine 27 acetylation (H3K27ac)-defined enhancers that functionally bind Cdx2, Eomes and Elf5-core factors that define the TSC regulatory network. Furthermore, we show that RLTR13D5 is capable of driving gene expression in rat placental cells. Analysis in other tissues shows that species-specific ERV enhancer activity is generally restricted to hypomethylated tissues, suggesting that tissues permissive for ERV activity gain access to an otherwise silenced source of regulatory variation. Overall, our results implicate ERV enhancer co-option as a mechanism underlying the extensive evolutionary diversification of placental development.
361 citations
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TL;DR: An overview of the clinically relevant pharmacology of selective serotonin reuptake inhibitors (SSRIs) with an emphasis on their pharmacokinetics and effects on cytochrome P450 (CYP) enzymes is presented.
Abstract: This paper presents an overview of the clinically relevant pharmacology of selective serotonin reuptake inhibitors (SSRIs) with an emphasis on their pharmacokinetics and effects on cytochrome P450 (CYP) enzymes. The SSRIs are potent inhibitors of the neuronal reuptake pump for serotonin (5-hydroxytryptamine; 5-HT) and have minimal effects on a number of other sites of actions (e.g. neuroreceptors and fast sodium channels). For this reason, drugs in this class have remarkable similarity as regards acute and maintenance antidepressant efficacy and tolerability profile.
360 citations
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Henry Ford Health System1, Icahn School of Medicine at Mount Sinai2, Medical University of South Carolina3, University of Texas Health Science Center at Houston4, Emory University5, University of Virginia6, Mayo Clinic7, University of Cincinnati8, University of Missouri9, University of California, San Diego10, National Institutes of Health11, University of Kansas12
TL;DR: The analysis suggests that EICs are prevalent within 3 hours of stroke onset and correlate with stroke severity, however, Eics are not independently associated with increased risk of adverse outcome after rt-PA treatment.
Abstract: ContextThe prevalence and clinical significance of early ischemic changes (EICs)
on baseline computed tomography (CT) scan of the head obtained within 3 hours
of ischemic stroke are not established.ObjectiveTo determine the frequency and significance of EIC on baseline head
CT scans in the National Institute of Neurological Disorders and Stroke (NINDS)
rt-PA (recombinant tissue plasminogen activator) Stroke Trial.Design and SettingThe original study, a randomized controlled trial, took place from January
1991 through October 1994 at 43 sites, during which CT images were obtained
within 3 hours of symptom onset and prior to the initiation of rt-PA or placebo.
For the current analysis, detailed reevaluation was undertaken after October
1994 of all baseline head CT scans with clinical data available pretreatment
(blinded to treatment arm).PatientsOf 624 patients enrolled in the trial, baseline CT scans were retrieved
and reviewed for 616 (99%).Main Outcome MeasuresFrequency of EICs on baseline CT scans; association of EIC with other
baseline variables; effect of EICs on deterioration at 24 hours (≥4 points
increase from the baseline National Institutes of Health Stroke Scale [NIHSS]
score); clinical outcome (measured by 4 clinical scales) at 3 months, CT lesion
volume at 3 months, death at 90 days; and symptomatic intracranial hemorrhage
(ICH) within 36 hours of treatment.ResultsThe prevalence of EIC on baseline CT in the combined rt-PA and placebo
groups was 31% (n = 194). The EIC was significantly associated with baseline
NIHSS score (ρ = 0.23; P<.001) and time from
stroke onset to baseline CT scan (ρ = 0.11; P
= .007). After adjusting for baseline variables, there was no EIC ×
treatment interaction detected for any clinical outcome, including deterioration
at 24 hours, 4 clinical scales, lesion volume, and death at 90 days (P≥.25), implying that EIC is unlikely to affect response
to rt-PA treatment. After adjusting for NIHSS score (an independent predictor
of ICH), no EIC association with symptomatic ICH at 36 hours was detected
in the group treated with rt-PA (P≥.22).ConclusionsOur analysis suggests that EICs are prevalent within 3 hours of stroke
onset and correlate with stroke severity. However, EICs are not independently
associated with increased risk of adverse outcome after rt-PA treatment. Patients
treated with rt-PA did better whether or not they had EICs, suggesting that
EICs on CT scan are not critical to the decision to treat otherwise eligible
patients with rt-PA within 3 hours of stroke onset.
360 citations
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TL;DR: An examination of the co-occurrence of clinical levels of BD, RD, and LI showed BD in children with LI to be conditioned by the child's reading status, and the association of LI with BD required the mediation of RD.
Abstract: Children with language impairment (LI) have been shown to be at risk for reading disability (RD) and behavior disorder (BD). Previous research has not determined the specific pattern of these conditions associated with LI. This study sought to determine if the behavior disorder and reading problems represented different outcomes or if these conditions occurred together when found with LI. A group of 581 second-grade children, including 164 children with LI, were examined for spoken language, reading, and behavior disorder. The data for each of these areas were examined as dimensional traits and as clinical categorical traits. Reading and spoken language were found to be strongly correlated (r = .68); RD was found in 52 % of the children with LI and in only 9 % of the controls. Scores of parent ratings for BD were also significantly correlated with spoken language scores (r = .29). Clinical levels of BD were found in 29% of the children with LI and 19% of the controls. An examination of the co-occurrence of clinical levels of BD, RD, and LI showed BD in children with LI to be conditioned by the child's reading status. The data indicated that whereas RD was directly associated with BD, the association of LI with BD required the mediation of RD.
359 citations
Authors
Showing all 38401 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gordon H. Guyatt | 231 | 1620 | 228631 |
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
Wei Li | 158 | 1855 | 124748 |
David Tilman | 158 | 340 | 149473 |
Tomas Hökfelt | 158 | 1033 | 95979 |
Pete Smith | 156 | 2464 | 138819 |
Daniel J. Rader | 155 | 1026 | 107408 |
Melody A. Swartz | 148 | 1304 | 103753 |
Kevin Murphy | 146 | 728 | 120475 |
Carlo Rovelli | 146 | 1502 | 103550 |
Stephen Sanders | 145 | 1385 | 105943 |
Marco Zanetti | 145 | 1439 | 104610 |
Andrei Gritsan | 143 | 1531 | 135398 |
Gunther Roland | 141 | 1471 | 100681 |
Joseph T. Hupp | 141 | 731 | 82647 |