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Institution

University of Kansas

EducationLawrence, Kansas, United States
About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.


Papers
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Journal ArticleDOI
TL;DR: The functional capacities that change with usual aging and that are further modified by hospitalization are outlined, along with the functional consequences of the interaction (Table 1).
Abstract: For many older persons, hospitalization results in functional decline despite cure or repair of the condition for which they were admitted. Hospitalization can result in complications unrelated to the problem that caused admission or to its specific treatment for reasons that are explainable and avoidable. Usual aging is often associated with functional change, such as a decline in muscle strength and aerobic capacity; vasomotor instability; reduced bone density; diminished pulmonary ventilation; altered sensory continence, appetite, and thirst; and a tendency toward urinary incontinence. Hospitalization and bed rest superimpose factors such as enforced immobilization, reduction of plasma volume, accelerated bone loss, increased closing volume, and sensory deprivation. Any of these factors may thrust vulnerable older persons into a state of irreversible functional decline. The factors that contribute to a cascade to dependency are identifiable and can be avoided by modification of the usual acute hospital environment by deemphasizing bed rest, removing the hazard of the high hospital bed with rails, and actively facilitating ambulation and socialization. The relationships among physicians, nurses, and other health professionals must reflect the importance of interdisciplinary care and the implementation of shared objectives.

1,270 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a set of performance criteria for single-use biosensors, i.e., a device that is both disposable after one measurement, and unable to monitor the analyte concentration continuously or after rapid and reproducible regeneration.

1,267 citations

Journal ArticleDOI
17 Feb 2006-Science
TL;DR: Using satellite radar interferometry observations of Greenland, widespread glacier acceleration below 66° north between 1996 and 2000, which rapidly expanded to 70° north in 2005, and as more glaciers accelerate farther north, the contribution of Greenland to sea-level rise will continue to increase.
Abstract: Using satellite radar interferometry observations of Greenland, we detected widespread glacier acceleration below 66° north between 1996 and 2000, which rapidly expanded to 70° north in 2005. Accelerated ice discharge in the west and particularly in the east doubled the ice sheet mass deficit in the last decade from 90 to 220 cubic kilometers per year. As more glaciers accelerate farther north, the contribution of Greenland to sea-level rise will continue to increase.

1,263 citations

Journal ArticleDOI
TL;DR: It is proposed that PXR serves as a physiological sensor of LCA, and coordinately regulates gene expression to reduce the concentrations of this toxic bile acid, and suggest that PxR agonists may prove useful in the treatment of human cholestatic liver disease.
Abstract: The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body from harmful chemicals. In this study, we demonstrate that PXR is activated by the toxic bile acid lithocholic acid (LCA) and its 3-keto metabolite. Furthermore, we show that PXR regulates the expression of genes involved in the biosynthesis, transport, and metabolism of bile acids including cholesterol 7α-hydroxylase (Cyp7a1) and the Na+-independent organic anion transporter 2 (Oatp2). Finally, we demonstrate that activation of PXR protects against severe liver damage induced by LCA. Based on these data, we propose that PXR serves as a physiological sensor of LCA, and coordinately regulates gene expression to reduce the concentrations of this toxic bile acid. These findings suggest that PXR agonists may prove useful in the treatment of human cholestatic liver disease.

1,255 citations

Journal ArticleDOI
TL;DR: It is shown that, comparing two ROCs, using the AUC systematically undervalues models that do not provide predictions across the entire spectrum of proportional areas in the study area.

1,252 citations


Authors

Showing all 38401 results

NameH-indexPapersCitations
Gordon H. Guyatt2311620228631
Krzysztof Matyjaszewski1691431128585
Wei Li1581855124748
David Tilman158340149473
Tomas Hökfelt158103395979
Pete Smith1562464138819
Daniel J. Rader1551026107408
Melody A. Swartz1481304103753
Kevin Murphy146728120475
Carlo Rovelli1461502103550
Stephen Sanders1451385105943
Marco Zanetti1451439104610
Andrei Gritsan1431531135398
Gunther Roland1411471100681
Joseph T. Hupp14173182647
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022358
20214,211
20204,204
20193,766
20183,485