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Institution

University of Kansas

EducationLawrence, Kansas, United States
About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.


Papers
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Journal ArticleDOI
TL;DR: It is shown that conditional inactivation of Bmpr1a in mice disturbs homeostasis of intestinal epithelial regeneration with an expansion of the stem and progenitor cell populations, eventually leading to intestinal polyposis resembling human juvenilePolyposis syndrome, and BMP signaling suppresses Wnt signaling to ensure a balanced control of stem cell self-renewal.
Abstract: In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The development of polyposis is a common feature of these diseases, suggesting that there is an association between BMP and PTEN pathways. The mechanistic link between BMP and PTEN pathways and the related etiology of juvenile polyposis is unresolved. Here we show that conditional inactivation of Bmpr1a in mice disturbs homeostasis of intestinal epithelial regeneration with an expansion of the stem and progenitor cell populations, eventually leading to intestinal polyposis resembling human juvenile polyposis syndrome. We show that BMP signaling suppresses Wnt signaling to ensure a balanced control of stem cell self-renewal. Mechanistically, PTEN, through phosphatidylinosital-3 kinase-Akt, mediates the convergence of the BMP and Wnt pathways on control of beta-catenin. Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number.

1,026 citations

Journal ArticleDOI
TL;DR: The case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes is presented.
Abstract: High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.

1,023 citations

Journal ArticleDOI
TL;DR: This paper found that imagining how the other feels produced empathy, but it also produced personal distress, which has been found to evoke egoistic motivation, and that the two imagine perspectives produced the predicted distinct pattern of emotions, suggesting different motivational consequences.
Abstract: Although often confused, imagining how another feels and imagining how you would feel are two distinct forms of perspective taking with different emotional consequences. The former evokes empathy; the latter, both empathy and distress. To test this claim, undergraduates listened to a (bogus) pilot radio interview with a young woman in serious need. One third were instructed to remain objective while listening; one third, to imagine how the young woman felt; and one third, to imagine how they would feel in her situation. The two imagine perspectives produced the predicted distinct pattern of emotions, suggesting different motivational consequences: Imagining how the other feels produced empathy, which has been found to evoke altruistic motivation; imagining how you would feel produced empathy, but it also produced personal distress, which has been found to evoke egoistic motivation.

1,021 citations

Journal ArticleDOI
TL;DR: The unusual structure of BST-2, which includes a transmembrane domain and a lumenal GPI anchor, may allow it to retain nascent enveloped virions on cellular membranes, providing a mechanism of viral restriction counteracted by a specific viral accessory protein.

1,018 citations

Journal ArticleDOI
02 Nov 2017-Nature
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Abstract: Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

1,014 citations


Authors

Showing all 38401 results

NameH-indexPapersCitations
Gordon H. Guyatt2311620228631
Krzysztof Matyjaszewski1691431128585
Wei Li1581855124748
David Tilman158340149473
Tomas Hökfelt158103395979
Pete Smith1562464138819
Daniel J. Rader1551026107408
Melody A. Swartz1481304103753
Kevin Murphy146728120475
Carlo Rovelli1461502103550
Stephen Sanders1451385105943
Marco Zanetti1451439104610
Andrei Gritsan1431531135398
Gunther Roland1411471100681
Joseph T. Hupp14173182647
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022358
20214,211
20204,204
20193,766
20183,485