Institution
University of Kelaniya
Education•Kelaniya, Sri Lanka•
About: University of Kelaniya is a education organization based out in Kelaniya, Sri Lanka. It is known for research contribution in the topics: Population & Poison control. The organization has 2098 authors who have published 2853 publications receiving 38576 citations. The organization is also known as: Vidyalankara University.
Topics: Population, Poison control, Thin film, Dengue fever, Mental health
Papers published on a yearly basis
Papers
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TL;DR: It is estimated that, globally, at least 421,000 envenomings and 20,000 deaths occur each year due to snakebite, with the highest burden exists in South Asia, Southeast Asia, and sub-Saharan Africa.
Abstract: Background Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer from the lack of an objective and reproducible methodology. In an attempt to provide an accurate, up-to-date estimate of the scale of the global problem, we developed a new method to estimate the disease burden due to snakebites. Methods and Findings The global estimates were based on regional estimates that were, in turn, derived from data available for countries within a defined region. Three main strategies were used to obtain primary data: electronic searching for publications on snakebite, extraction of relevant countryspecific mortality data from databases maintained by United Nations organizations, and identification of grey literature by discussion with key informants. Countries were grouped into 21 distinct geographic regions that are as epidemiologically homogenous as possible, in line with the Global Burden of Disease 2005 study (Global Burden Project of the World Bank). Incidence rates for envenoming were extracted from publications and used to estimate the number of envenomings for individual countries; if no data were available for a particular country, the lowest incidence rate within a neighbouring country was used. Where death registration data were reliable, reported deaths from snakebite were used; in other countries, deaths were estimated on the basis of observed mortality rates and the at-risk population. We estimate that, globally, at least 421,000 envenomings and 20,000 deaths occur each year due to snakebite. These figures may be as high as 1,841,000 envenomings and 94,000 deaths. Based on the fact that envenoming occurs in about one in every four snakebites, between 1.2 million and 5.5 million snakebites could occur annually.
1,469 citations
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TL;DR: In insights into the role of alcohol consumption in the genetic architecture of hypertension, a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions is conducted.
Abstract: Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in ≈440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
1,218 citations
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TL;DR: Global estimates of soil-transmitted helminth infections are brought up to date, some interesting new trends are revealed and the future for control is discussed.
1,139 citations
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University of Florida1, Utrecht University2, Australian National University3, University of Zurich4, Technical University of Denmark5, Institute of Tropical Medicine Antwerp6, Boston Children's Hospital7, University of Kelaniya8, Université catholique de Louvain9, World Health Organization10, Centers for Disease Control and Prevention11
TL;DR: The Foodborne Disease Burden Epidemiology Reference Group (FERG) reports their first estimates of the incidence, mortality, and disease burden due to 31 foodborne hazards, finding that the global burden of FBD is comparable to those of the major infectious diseases, HIV/AIDS, malaria and tuberculosis.
Abstract: Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide. To measure the global and regional burden of foodborne disease (FBD), the World Health Organization (WHO) established the Foodborne Disease Burden Epidemiology Reference Group (FERG), which here reports their first estimates of the incidence, mortality, and disease burden due to 31 foodborne hazards. We find that the global burden of FBD is comparable to those of the major infectious diseases, HIV/AIDS, malaria and tuberculosis. The most frequent causes of foodborne illness were diarrheal disease agents, particularly norovirus and Campylobacter spp. Diarrheal disease agents, especially non-typhoidal Salmonella enterica, were also responsible for the majority of deaths due to FBD. Other major causes of FBD deaths were Salmonella Typhi, Taenia solium and hepatitis A virus. The global burden of FBD caused by the 31 hazards in 2010 was 33 million Disability Adjusted Life Years (DALYs); children under five years old bore 40% of this burden. The 14 subregions, defined on the basis of child and adult mortality, had considerably different burdens of FBD, with the greatest falling on the subregions in Africa, followed by the subregions in South-East Asia and the Eastern Mediterranean D subregion. Some hazards, such as non-typhoidal S. enterica, were important causes of FBD in all regions of the world, whereas others, such as certain parasitic helminths, were highly localised. Thus, the burden of FBD is borne particularly by children under five years old-although they represent only 9% of the global population-and people living in low-income regions of the world. These estimates are conservative, i.e., underestimates rather than overestimates; further studies are needed to address the data gaps and limitations of the study. Nevertheless, all stakeholders can contribute to improvements in food safety throughout the food chain by incorporating these estimates into policy development at national and international levels.
1,130 citations
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University of Delhi1, University of New South Wales2, Post Graduate Institute of Medical Education and Research3, University of Hong Kong4, University of Kelaniya5, The Aga Khan University Hospital6, University College London7, Chulalongkorn University8, Capital Medical University9, University of Malaya10, Huazhong University of Science and Technology11, Bangabandhu Sheikh Mujib Medical University12, French Institute of Health and Medical Research13, Jaslok Hospital14, Iwate Medical University15, Gleneagles Hospital16
TL;DR: The original proposed definition of ACLF was found to withstand the test of time and identify a homogenous group of patients presenting with liver failure, which led to the development of the final AARC consensus.
Abstract: The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region. Experts predominantly from the Asia–Pacific region constituted this working party and were requested to identify different issues of ACLF and develop the consensus guidelines. A 2-day meeting of the working party was held on January 22–23, 2008, at New Delhi, India, to discuss and finalize the consensus statements. Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and subsequently presented at the Annual Conference of the APASL at Seoul, Korea, in March 2008. The consensus statements along with relevant background information are presented in this review.
1,125 citations
Authors
Showing all 2114 results
Name | H-index | Papers | Citations |
---|---|---|---|
David J. Weatherall | 97 | 519 | 42215 |
Marc A. Benninga | 72 | 651 | 19674 |
Sena S. De Silva | 43 | 129 | 4886 |
H. Janaka de Silva | 34 | 89 | 7015 |
Shaman Rajindrajith | 29 | 86 | 2229 |
H.J. de Silva | 29 | 163 | 3568 |
Kasun M. Thambugala | 27 | 62 | 3619 |
Chris Fisher | 26 | 74 | 3266 |
Niranga Manjuri Devanarayana | 26 | 80 | 1648 |
Ananda R. Wickremasinghe | 26 | 109 | 5433 |
Anuradhani Kasturiratne | 23 | 82 | 5267 |
Nilanthi de Silva | 22 | 52 | 5419 |
Fiona Kumari Campbell | 21 | 73 | 2607 |
Arunasalam Pathmeswaran | 21 | 132 | 2846 |
Upali S. Amarasinghe | 21 | 105 | 1487 |