University of Kentucky

About: University of Kentucky is a education organization based out in Lexington, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 43933 authors who have published 92195 publications receiving 3256087 citations. The organization is also known as: UK.

Thermal and Flammability Properties of Polypropylene/Carbon Nanotube Nanocomposites

Abstract: The thermal and flammability properties of polypropylene/multi-walled carbon nanotube, (PP/MWNT) nanocomposites were measured with the MWNT content varied from 0.5 to 4% by mass. Dispersion of MWNTs in these nanocomposites was characterized by SEM and optical microscopy. Flammability properties were measured with a cone calorimeter in air and a gasification device in a nitrogen atmosphere. A significant reduction in the peak heat release rate was observed; the greatest reduction was obtained with a MWNT content of 1% by mass. Since the addition of carbon black powder to PP did not reduce the heat release rate as much as with the PP/MWNT nanocomposites, the size and shape of carbon particles appear to be important for effectively reducing the flammability of PP. The radiative ignition delay time of a nanocomposite having less than 2% by mass of MWNT was shorter than that of PP due to an increase in the radiation in-depth absorption coefficient by the addition of carbon nanotubes. The effects of residual iron particles and of defects in the MWNTs on the heat release rate of the nanocomposite were not significant. The flame retardant performance was achieved through the formation of a relatively uniform network-structured floccule layer covering the entire sample surface without any cracks or gaps. This layer re-emitted much of the incident radiation back into the gas phase from its hot surface and thus reduced the transmitted flux to the receding PP layers below it, slowing the PP pyrolysis rate. To gain insight into this phenomena, thermal conductivities of the nanocomposites were measured as a function of temperature while the thermal conductivity of the nanocomposite increases with an increase in MWNT content, the effect being particularly large above 160 °C, this increase is not as dramatic as the increase in electrical conductivity, however.

Personality and sexual risk taking: a quantitative review.

Abstract: Findings from a quantitative review of the empirical research literature on normal personality and sexual risk taking are reported. The review focuses on domains identified in major models of normal personality representing the psychobiological and taxonomic perspectives. Focal sexual risk-taking behaviors were number of partners, unprotected sex, and high-risk sexual encounters (e.g., sex with a stranger). A comprehensive search produced 53 studies relevant to the review. A striking feature of the results is the paucity of research on domains of normal personality and sexual risk taking for all domains other than sensation seeking, which accounted for 64% of the effect sizes. The preponderance of studies (81%) took the psychobiological perspective and were published since 1990 (75%). Among the substantive findings were effects for sensation seeking, impulsivity, and agreeableness on all sexual risk-taking behaviors considered. Additionally, there were effects on specific behaviors for neuroticism and conscientiousness. The implications of these findings for future research on normal personality and sexual risk taking are discussed.

Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier

Abstract: Nanoparticles (NP) are solid colloidal particles ranging in size from 1 to 1000 nm that are utilized as drug delivery agents. The use of NPs to deliver drugs to the brain across the blood-brain barrier (BBB) may provide a significant advantage to current strategies. The primary advantage of NP carrier technology is that NPs mask the blood-brain barrier limiting characteristics of the therapeutic drug molecule. Furthermore, this system may slow drug release in the brain, decreasing peripheral toxicity. This review evaluates previous strategies of brain drug delivery, discusses NP transport across the BBB, and describes primary methods of NP preparation and characterization. Further, influencing manufacturing factors (type of polymers and surfactants, NP size, and the drug molecule) are detailed in relation to movement of the drug delivery agent across the BBB. Currently, reports evaluating NPs for brain delivery have studied anesthetic and chemotherapeutic agents. These studies are reviewed for efficacy and mechanisms of transport. Physiological factors such as phagocytic activity of the reticuloendothelial system and protein opsonization may limit the amount of brain delivered drug and methods to avoid these issues are also discussed. NP technology appears to have significant promise in delivering therapeutic molecules across the BBB.

Magnetic fields in interstellar clouds from zeeman observations: inference of total field strengths by bayesian analysis

Abstract: The only direct measurements of interstellar magnetic field strengths depend on the Zeeman effect, which samples the line-of-sight component B{sub z} of the magnetic vector. In this paper, we use a Bayesian approach to analyze the observed probability density function (PDF) of B{sub z} from Zeeman surveys of H I, OH, and CN spectral lines in order to infer a density-dependent stochastic model of the total field strength B in diffuse and molecular clouds. We find that at n 300 cm{sup -3}, with an uncertainty at the 50% level in the power-law exponent of about {+-}0.05. This break-point density could be interpreted as the average density at which parsec-scale clouds become self-gravitating. Both the uniform PDF of total field strengths and the scalingmore » with density suggest that magnetic fields in molecular clouds are often too weak to dominate the star formation process. The stochasticity of the total field strength B implies that many fields are so weak that the mass/flux ratio in many clouds must be significantly supercritical. A two-thirds power law comes from isotropic contraction of gas too weakly magnetized for the magnetic field to affect the morphology of the collapse. On the other hand, our study does not rule out some clouds having strong magnetic fields with critical mass/flux ratios.« less