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Institution

University of Kentucky

EducationLexington, Kentucky, United States
About: University of Kentucky is a education organization based out in Lexington, Kentucky, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 43933 authors who have published 92195 publications receiving 3256087 citations. The organization is also known as: UK.


Papers
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Journal ArticleDOI
TL;DR: The privacy threats in blockchain are analyzed and existing cryptographic defense mechanisms, i.e., anonymity and transaction privacy preservation, are discussed to preserve privacy when blockchain is used.

531 citations

Journal ArticleDOI
TL;DR: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease.
Abstract: Objective: To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). Methods: The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD. Results: Elevated levels of protein carbonyls (∼25%), malondialdehyde (∼60%), and TBARS (∼210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined. Conclusion: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease.

531 citations

Journal ArticleDOI
01 Jun 2008-Cancer
TL;DR: The physical and psychological long‐term and late effects among adult survivors of pediatric and adult cancers are described and the emergence of public health initiatives and large‐scale research activities that address the issues of long-term cancer survivorship are discussed.
Abstract: The number of long-term cancer survivors (> or =5 years after diagnosis) in the U.S. continues to rise, with more than 10 million Americans now living with a history of cancer. Along with such growth has come increasing attention to the continued health problems and needs of this population. Many cancer survivors return to normal functioning after the completion of treatment and are able to live relatively symptom-free lives. However, cancer and its treatment can also result in a wide range of physical and psychological problems that do not recede with time. Some of these problems emerge during or after cancer treatment and persist in a chronic, long-term manner. Other problems may not appear until months or even years later. Regardless of when they present, long-term and late effects of cancer can have a negative effect on cancer survivors' quality of life. This article describes the physical and psychological long-term and late effects among adult survivors of pediatric and adult cancers. The focus is on the prevalence and correlates of long-term and late effects as well as the associated deficits in physical and emotional functioning. In addition, the emergence of public health initiatives and large-scale research activities that address the issues of long-term cancer survivorship are discussed. Although additional research is needed to fully understand and document the long-term and late effects of cancer, important lessons can be learned from existing knowledge. Increased awareness of these issues is a key component in the development of follow-up care plans that may allow for adequate surveillance, prevention, and the management of long-term and late effects of cancer.

531 citations

Journal ArticleDOI
TL;DR: In this article, the potential advantages and disadvantages of capital tax competition are discussed, and tax competition may introduce, mitigate, or exacerbate inefficiencies in both the private sector and the public sector.

531 citations

Journal ArticleDOI
TL;DR: Copper (Cu), iron (Fe), and zinc (Zn) levels in five different brain regions were determined by instrumental neutron activation analysis (INAA) in samples from Alzheimer's disease patients and age-matched control subjects.

531 citations


Authors

Showing all 44305 results

NameH-indexPapersCitations
Mark P. Mattson200980138033
Carlo M. Croce1981135189007
Charles A. Dinarello1901058139668
Richard A. Gibbs172889249708
Gang Chen1673372149819
David A. Bennett1671142109844
Carl W. Cotman165809105323
Rodney S. Ruoff164666194902
David Tilman158340149473
David Cella1561258106402
Richard E. Smalley153494111117
Deepak L. Bhatt1491973114652
Kevin Murphy146728120475
Jian Yang1421818111166
Thomas J. Smith1401775113919
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023108
2022532
20214,329
20204,216
20193,965
20183,605